Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

Formation of co-transcriptional R-loops underlies replication fork stalling upon head-on transcription-replication encounters. Here, we demonstrate that RAD51-dependent replication fork reversal induced by R-loops is followed by the restart of semiconservative DNA replication mediated by RECQ1 and R...

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Veröffentlicht in:	Molecular cell Jg. 77; H. 3; S. 528
Hauptverfasser:	Chappidi, Nagaraja, Nascakova, Zuzana, Boleslavska, Barbora, Zellweger, Ralph, Isik, Esin, Andrs, Martin, Menon, Shruti, Dobrovolna, Jana, Balbo Pogliano, Chiara, Matos, Joao, Porro, Antonio, Lopes, Massimo, Janscak, Pavel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.02.2020
Schlagworte:	Cell Line, Tumor DNA Ligases - metabolism DNA Polymerase III - metabolism DNA Replication - genetics DNA Replication - physiology DNA-Binding Proteins - metabolism Endodeoxyribonucleases - metabolism Endonucleases - genetics Endonucleases - metabolism HeLa Cells Humans R-Loop Structures - genetics R-Loop Structures - physiology Rad51 Recombinase - genetics Rad51 Recombinase - metabolism Rad51 Recombinase - physiology Rad52 DNA Repair and Recombination Protein - metabolism RecQ Helicases - metabolism RecQ Helicases - physiology Transcription, Genetic - genetics MUS81 replication stress transcription-replication conflict R-loop replication restart RECQ5 DNA ligase IV replication fork reversal
ISSN:	1097-4164, 1097-4164
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