Monitoring the maturation of the sarcomere network: a super-resolution microscopy-based approach

The in vitro generation of human cardiomyocytes derived from induced pluripotent stem cells (iPSC) is of great importance for cardiac disease modeling, drug-testing applications and for regenerative medicine. Despite the development of various cultivation strategies, a sufficiently high degree of ma...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS Jg. 79; H. 3; S. 149
Hauptverfasser:	Skorska, Anna, Johann, Lisa, Chabanovska, Oleksandra, Vasudevan, Praveen, Kussauer, Sophie, Hillemanns, Maximilian, Wolfien, Markus, Jonitz-Heincke, Anika, Wolkenhauer, Olaf, Bader, Rainer, Lang, Hermann, David, Robert, Lemcke, Heiko
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Springer International Publishing 01.03.2022 Springer Nature B.V
Schlagworte:	Actinin Actinin - metabolism adults Animals Biochemistry Biomedical and Life Sciences Biomedicine Calcium - metabolism Calcium Signaling - physiology Cardiomyocytes Cell Biology Cell culture Cell differentiation Cell Differentiation - physiology Cell morphology cell structures Cells, Cultured Coronary artery disease Cultivation Cytology Filaments Fluorescence Heart diseases Humans Image acquisition Image analysis Image processing Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Learning algorithms Life Sciences Machine Learning Maturation medicine Mice Microscopy Microscopy, Fluorescence - methods Muscle contraction Muscle, Skeletal - cytology Muscles Myocardium - cytology Neonates Original Original Article Phenotype Phenotypes Pluripotency quantitative analysis Regenerative medicine RNA - genetics RNA - isolation & purification sarcomeres Sarcomeres - metabolism Skeletal muscle Stem cells Tissue engineering Workflow Super resolution microscopy Sarcomere network Maturation iPSC cardiomyocytes
ISSN:	1420-682X, 1420-9071, 1420-9071
Online-Zugang:	Volltext
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