Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a s...

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Published in:Euro surveillance : bulletin européen sur les maladies transmissibles Vol. 25; no. 11
Main Authors: Haveri, Anu, Smura, Teemu, Kuivanen, Suvi, Österlund, Pamela, Hepojoki, Jussi, Ikonen, Niina, Pitkäpaasi, Marjaana, Blomqvist, Soile, Rönkkö, Esa, Kantele, Anu, Strandin, Tomas, Kallio-Kokko, Hannimari, Mannonen, Laura, Lappalainen, Maija, Broas, Markku, Jiang, Miao, Siira, Lotta, Salminen, Mika, Puumalainen, Taneli, Sane, Jussi, Melin, Merit, Vapalahti, Olli, Savolainen-Kopra, Carita
Format: Journal Article
Language:English
Published: Sweden European Centre for Disease Prevention and Control (ECDC) 19.03.2020
Subjects:
Adult
Antibodies, Viral - blood
Asymptomatic Infections
Betacoronavirus
China
Clinical Laboratory Techniques
Contact Tracing
Coronavirus - genetics
Coronavirus - immunology
Coronavirus - isolation & purification
Coronavirus Infections - diagnosis
Coronavirus Infections - transmission
Coronavirus Infections - virology
COVID-19
COVID-19 Testing
Female
Finland
Fluorescent Antibody Technique
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Immunoglobulin M - blood
Neutralization Tests
Pandemics
Pneumonia, Viral - diagnosis
Pneumonia, Viral - transmission
Pneumonia, Viral - virology
Rapid Communication
SARS Virus - immunology
SARS Virus - pathogenicity
SARS-CoV-2
Severe Acute Respiratory Syndrome - etiology
Severe Acute Respiratory Syndrome - immunology
Severe Acute Respiratory Syndrome - virology
Travel
Viral Envelope Proteins
China
Finland
COVID-19
SARS-CoV-2
humoral immunity
whole-genome sequencing
immunofluorescence assay
coronavirus
microneutralisation test
antibodies
western blotting
ISSN:1560-7917, 1025-496X, 1560-7917
Online Access:Get full text
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Summary:The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.
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Correspondence: Anu Haveri (anu.haveri@thl.fi)
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2020.25.11.2000266