Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas

The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previousl...

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Vydáno v:	Cancer research (Chicago, Ill.) Ročník 73; číslo 20; s. 6219
Hlavní autoři:	Paugh, Barbara S, Zhu, Xiaoyan, Qu, Chunxu, Endersby, Raelene, Diaz, Alexander K, Zhang, Junyuan, Bax, Dorine A, Carvalho, Diana, Reis, Rui M, Onar-Thomas, Arzu, Broniscer, Alberto, Wetmore, Cynthia, Zhang, Jinghui, Jones, Chris, Ellison, David W, Baker, Suzanne J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.10.2013
Témata:	Adolescent Animals Brain Neoplasms - genetics Brain Neoplasms - pathology Child Child, Preschool Gene Expression Profiling Genome-Wide Association Study Glioma - genetics Glioma - pathology Humans Mice Mutation Receptor, Platelet-Derived Growth Factor alpha - genetics Receptor, Platelet-Derived Growth Factor alpha - metabolism
ISSN:	1538-7445, 1538-7445
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