Host genetic control of gut microbiome composition

The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05–0.45), indicating that 5–45% of inter-...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mammalian genome Ročník 32; číslo 4; s. 263 - 281
Hlavní autoři: Bubier, Jason A., Chesler, Elissa J., Weinstock, George M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.08.2021
Springer Nature B.V
Témata:
Abundance
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Digestive system
Disease
disease control
Gastrointestinal Microbiome - genetics
Gene expression
Genetic control
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - microbiology
Genetic diversity
Genetic engineering
Genetic Predisposition to Disease
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genotype & phenotype
Gut microbiota
Heritability
Host-Pathogen Interactions - genetics
Human Genetics
Humans
Intestinal microflora
intestinal microorganisms
Life Sciences
Mice
Mice, Knockout
microbiome
Microbiomes
Microbiota
phenotype
Phenotypes
RNA, Ribosomal, 16S - genetics
Twin studies
ISSN:0938-8990, 1432-1777, 1432-1777
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05–0.45), indicating that 5–45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.
AbstractList The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05-0.45), indicating that 5-45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05-0.45), indicating that 5-45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.
The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05-0.45), indicating that 5-45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.
Author Chesler, Elissa J.
Weinstock, George M.
Bubier, Jason A.
Author_xml – sequence: 1
  givenname: Jason A.
  orcidid: 0000-0001-5013-1234
  surname: Bubier
  fullname: Bubier, Jason A.
  email: Jason.Bubier@jax.org
  organization: The Jackson Laboratory for Mammalian Genetics
– sequence: 2
  givenname: Elissa J.
  surname: Chesler
  fullname: Chesler, Elissa J.
  organization: The Jackson Laboratory for Mammalian Genetics
– sequence: 3
  givenname: George M.
  surname: Weinstock
  fullname: Weinstock, George M.
  organization: The Jackson Laboratory for Genomic Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34159422$$D View this record in MEDLINE/PubMed
BookMark eNqFkT1PHDEYhK0IFA6SP5AiWikNzcLrb7tBihAJkZBoSG15vfbFaNe-rHeR-Pf4OMgHBVQu3mdG45lDtJdy8gh9wnCCAeRpAaCUt0BwC1op1pJ3aIUZJS2WUu6hFWiqWqU1HKDDUm4BsBRYvkcHlGGuGSErRC5zmZu1T36OrnE5zVMemhya9TI3Y3RT7mIefb2Mm1ziHHP6gPaDHYr_-PQeoZ_fLm7OL9ur6-8_zr9etY6DnFveCe8BnKOd0jRgpl0HVoNwNWFPvBAhCEtlj53qcPABWK_7PvTUWd5RSo_Q2c53s3Sj752v2exgNlMc7XRvso3m_0uKv8w63xlFNAcN1eD4yWDKvxdfZjPG4vww2OTzUgwRVHCqqGZvo5wxJgioreuXF-htXqZUm6gUpwJriXmlPv8b_k_q5-YroHZArbiUyQfj4my3_da_xMFgMNuRzW5kU0c2jyObrZS8kD67vyqiO1GpcFr76W_sV1QP8Ra5KA
CitedBy_id crossref_primary_10_1186_s12903_023_03442_9
crossref_primary_10_3389_fpsyt_2022_800245
crossref_primary_10_1016_j_physbeh_2025_114989
crossref_primary_10_1016_j_nbt_2025_01_006
crossref_primary_10_1007_s00253_024_13002_y
crossref_primary_10_3390_ijms26178658
crossref_primary_10_32604_biocell_2024_051318
crossref_primary_10_1186_s42523_023_00262_8
crossref_primary_10_3390_jpm14020217
crossref_primary_10_3389_fmicb_2023_1107485
crossref_primary_10_1016_j_foodres_2024_114358
crossref_primary_10_1111_ele_70186
crossref_primary_10_1080_07853890_2025_2451191
crossref_primary_10_1016_j_cell_2025_05_014
crossref_primary_10_1042_BST20220004
crossref_primary_10_1017_gmb_2023_3
crossref_primary_10_1371_journal_pntd_0011306
crossref_primary_10_1016_j_tim_2024_08_002
crossref_primary_10_5306_wjco_v16_i9_111379
crossref_primary_10_1007_s10620_024_08647_8
crossref_primary_10_1016_j_fbio_2024_105681
crossref_primary_10_3389_fmicb_2024_1484134
crossref_primary_10_1007_s11274_025_04504_6
crossref_primary_10_3389_fitd_2025_1620822
crossref_primary_10_3389_fmicb_2022_825942
crossref_primary_10_3389_frph_2024_1431306
crossref_primary_10_1007_s11427_024_2759_3
crossref_primary_10_3390_cimb47060424
crossref_primary_10_1128_msphere_00059_24
crossref_primary_10_1111_gbb_70025
crossref_primary_10_1080_10408398_2024_2435593
crossref_primary_10_1093_molbev_msad093
crossref_primary_10_1016_j_nutres_2024_11_008
crossref_primary_10_1097_MS9_0000000000002276
crossref_primary_10_1016_j_neuropharm_2022_109409
crossref_primary_10_3390_ijms26073015
crossref_primary_10_1080_19490976_2024_2387794
crossref_primary_10_1111_gbb_12845
crossref_primary_10_1016_j_tig_2022_05_016
crossref_primary_10_3389_fmicb_2024_1411328
crossref_primary_10_3390_microorganisms11020358
crossref_primary_10_3390_microorganisms12061033
crossref_primary_10_3390_microorganisms13010090
crossref_primary_10_1093_femsec_fiae135
crossref_primary_10_3389_fmicb_2024_1476845
crossref_primary_10_1186_s40168_024_01954_2
crossref_primary_10_3390_biomedicines13061297
crossref_primary_10_1186_s40168_022_01440_7
crossref_primary_10_1016_j_brainresbull_2023_110862
crossref_primary_10_1038_s41396_022_01315_7
crossref_primary_10_1016_j_brainresbull_2023_110665
crossref_primary_10_1002_advs_202416325
crossref_primary_10_3389_fimmu_2022_983344
crossref_primary_10_3389_fimmu_2024_1407620
crossref_primary_10_3389_fmicb_2023_1209158
crossref_primary_10_3390_cells10092204
crossref_primary_10_1080_19490976_2024_2341647
crossref_primary_10_1186_s40168_024_01771_7
Cites_doi 10.1111/mec.15139
10.1038/s41598-019-49452-y
10.1038/mp.2013.65
10.1371/journal.pone.0039191
10.1136/gut.2010.216259
10.1126/science.1241214
10.1146/annurev-genom-090711-163814
10.1007/s00018-019-03359-z
10.1038/s41579-020-0438-4
10.1038/s41586-020-2541-0
10.1186/s13059-016-1052-7
10.1371/journal.pone.0003064
10.1038/mp.2012.77
10.1038/ncomms7440
10.1534/genetics.119.303013
10.1186/s13059-015-0759-1
10.1038/s42003-020-01416-z
10.1371/journal.pone.0072317
10.1111/lam.12882
10.1126/science.1124234
10.1093/jn/133.7.2485S
10.1371/journal.pone.0224100
10.1136/gutjnl-2015-311326
10.1371/journal.pone.0034242
10.1038/s41586-019-1312-2
10.1371/journal.pbio.1001212
10.1186/s13073-014-0107-1
10.1016/j.cgh.2018.08.067
10.1016/0092-8674(94)90407-3
10.1007/s11605-009-1045-x
10.1038/nature07540
10.1016/j.bbr.2015.10.046
10.1371/journal.pone.0140301
10.1111/j.1462-5822.2007.01108.x
10.1016/j.cell.2009.09.033
10.1093/ofid/ofaa114
10.1038/nm.4102
10.1038/nmicrobiol.2016.221
10.1073/pnas.1010529108
10.1038/ng.3663
10.1152/ajpregu.00026.2008
10.1016/j.tig.2019.04.003
10.1126/science.1058709
10.1128/AEM.00880-18
10.1038/nature13793
10.1371/journal.pgen.1008073
10.1016/j.chom.2016.04.017
10.1038/s41576-019-0127-1
10.1101/gr.194118.115
10.1038/nature25973
10.1016/j.intimp.2019.105901
10.1038/s41598-017-11744-6
10.1016/j.trsl.2017.08.005
10.1016/j.chom.2008.02.015
10.1038/mp.2016.44
10.1016/j.bbi.2016.02.020
10.1038/ni.1991
10.1038/nature03001
10.3389/fneur.2020.00978
10.7554/eLife.01202
10.1534/genetics.111.132597
10.1016/j.clinthera.2015.04.004
10.3390/genes11091041
10.1038/nature11234
10.1053/j.gastro.2014.08.033
10.1371/journal.pone.0036095
10.1177/0963689719873890
10.3389/fmicb.2011.00149
10.1038/nature08494
10.1369/0022155413519650
10.1038/s41467-019-13836-5
10.1073/pnas.0307317101
10.1016/0167-5699(93)90160-M
10.1002/ibd.21339
10.1126/science.1179721
10.1038/nature12721
10.1038/ng.3695
10.1016/j.cell.2014.09.053
10.1038/s41586-020-2604-2
10.1016/j.cell.2016.11.018
10.1007/s00428-017-2277-x
10.1016/j.cell.2019.12.025
10.1371/journal.pone.0062578
10.1016/j.chom.2018.08.009
10.1038/ismej.2009.112
10.1016/j.cell.2016.01.013
10.1152/physrev.00018.2018
10.1111/j.1365-2982.2010.01620.x
10.1038/s41588-020-00763-1
10.1097/MOG.0000000000000139
10.1371/journal.pone.0020113
10.1126/science.1104816
10.1038/ng.3693
10.4049/jimmunol.180.2.1139
10.1038/s41598-019-51525-x
10.3390/metabo10050181
10.1126/science.1254009
10.4049/jimmunol.1700037
10.1038/s41564-020-0743-8
10.1073/pnas.1002601107
10.1073/pnas.1001269107
10.1007/s00335-011-9343-5
10.1073/pnas.0504978102
10.1126/science.286.5437.113
10.1038/ismej.2012.54
10.1038/ni.1825
10.1126/science.1209791
10.1002/gepi.20297
10.1038/nmicrobiol.2016.131
10.1016/j.cell.2011.04.022
10.1016/j.cels.2016.10.004
10.1038/s41684-020-00660-4
10.1016/j.psychres.2020.113471
10.1126/science.aab3958
10.1073/pnas.1106408108
10.1002/jcp.25407
10.1186/gb-2013-14-1-r1
10.1073/pnas.1007028107
10.1080/19490976.2017.1356556
10.1038/nature01262
10.1016/j.chom.2010.07.005
10.1038/nbt.3353
10.1186/s13059-014-0552-6
10.1038/nature07336
ContentType Journal Article
Copyright The Author(s) 2021
2021. The Author(s).
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: 2021. The Author(s).
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7TK
7X7
7XB
88A
88E
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
7S9
L.6
5PM
DOI 10.1007/s00335-021-09884-2
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
ProQuest Central Student


AGRICOLA
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Zoology
EISSN 1432-1777
EndPage 281
ExternalDocumentID PMC8295090
34159422
10_1007_s00335_021_09884_2
Genre Journal Article
Review
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: National Institute on Drug Abuse
  grantid: U01 DA043809; U01 DA043809; P50 DA039841
  funderid: http://dx.doi.org/10.13039/100000026
– fundername: NIDA NIH HHS
  grantid: P50 DA039841
– fundername: NIDA NIH HHS
  grantid: U01 DA043809
– fundername: ;
  grantid: U01 DA043809; U01 DA043809; P50 DA039841
GroupedDBID ---
-4W
-56
-5G
-BR
-EM
-Y2
-~C
-~X
.86
.GJ
.VR
06C
06D
0R~
0VY
199
1N0
1SB
2.D
203
28-
29M
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
36B
3SX
3V.
4.4
406
408
409
40D
40E
53G
5GY
5QI
5VS
67N
67Z
6NX
78A
7X7
88A
88E
8AO
8FE
8FH
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AACDK
AAHBH
AAHNG
AAIAL
AAJBT
AAJKR
AANXM
AANZL
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
ABAKF
ABBBX
ABBXA
ABDBF
ABDZT
ABECU
ABFTV
ABHLI
ABHQN
ABJNI
ABJOX
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABQBU
ABQSL
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACAOD
ACBXY
ACDTI
ACGFS
ACHSB
ACHXU
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPIV
ACPRK
ACUHS
ACZOJ
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEFIE
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AEMSY
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEVLU
AEXYK
AFBBN
AFEXP
AFFNX
AFGCZ
AFKRA
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHMBA
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
B0M
BA0
BBNVY
BBWZM
BDATZ
BENPR
BGNMA
BHPHI
BPHCQ
BSONS
BVXVI
C6C
CAG
CCPQU
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
EAD
EAP
EBD
EBLON
EBS
EIOEI
EJD
EMB
EMK
EMOBN
EN4
EPAXT
EPL
ESBYG
ESX
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GXS
H13
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
LAS
LK8
LLZTM
M0L
M1P
M4Y
M7P
MA-
N2Q
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
P2P
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
RNI
ROL
RPX
RRX
RSV
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBL
SBY
SCLPG
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TN5
TSG
TSK
TSV
TUC
TUS
U2A
U9L
UG4
UKHRP
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WJK
WK6
WK8
YLTOR
Z45
Z7U
Z82
Z87
Z8O
Z8V
Z91
ZGI
ZMTXR
ZOVNA
ZXP
~8M
~A9
~EX
~KM
AAPKM
AAYXX
ABBRH
ABDBE
ABFSG
ABRTQ
ACSTC
ADHKG
AEZWR
AFDZB
AFFHD
AFHIU
AFOHR
AGQPQ
AHPBZ
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7TK
7XB
8FD
8FK
AZQEC
DWQXO
FR3
GNUQQ
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
7X8
7S9
L.6
PUEGO
5PM
ID FETCH-LOGICAL-c507t-5b6ee00cc3b893f149cb0a906c432d2e66ff6a37d1c8b1fef04d9ddfd3ca5b333
IEDL.DBID M7P
ISICitedReferencesCount 64
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000664433600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0938-8990
1432-1777
IngestDate Tue Nov 04 02:01:51 EST 2025
Sun Sep 28 09:33:52 EDT 2025
Sun Nov 09 13:21:31 EST 2025
Wed Nov 05 00:26:14 EST 2025
Wed Feb 19 02:11:23 EST 2025
Sat Nov 29 01:39:59 EST 2025
Tue Nov 18 21:55:22 EST 2025
Fri Feb 21 02:47:41 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License 2021. The Author(s).
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c507t-5b6ee00cc3b893f149cb0a906c432d2e66ff6a37d1c8b1fef04d9ddfd3ca5b333
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0001-5013-1234
OpenAccessLink https://link.springer.com/10.1007/s00335-021-09884-2
PMID 34159422
PQID 2553619715
PQPubID 54093
PageCount 19
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8295090
proquest_miscellaneous_2636538394
proquest_miscellaneous_2544462080
proquest_journals_2553619715
pubmed_primary_34159422
crossref_citationtrail_10_1007_s00335_021_09884_2
crossref_primary_10_1007_s00335_021_09884_2
springer_journals_10_1007_s00335_021_09884_2
PublicationCentury 2000
PublicationDate 2021-08-01
PublicationDateYYYYMMDD 2021-08-01
PublicationDate_xml – month: 08
  year: 2021
  text: 2021-08-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationSubtitle Precision and Functional Genomics
PublicationTitle Mammalian genome
PublicationTitleAbbrev Mamm Genome
PublicationTitleAlternate Mamm Genome
PublicationYear 2021
Publisher Springer US
Springer Nature B.V
Publisher_xml – name: Springer US
– name: Springer Nature B.V
References Wang, Thingholm, Skieceviciene, Rausch, Kummen, Hov, Degenhardt, Heinsen, Ruhlemann, Szymczak, Holm, Esko, Sun, Pricop-Jeckstadt, Al-Dury, Bohov, Bethune, Sommer, Ellinghaus, Berge, Hubenthal, Koch, Schwarz, Rimbach, Hubbe, Pan, Sheibani-Tezerji, Hasler, Rosenstiel, D'Amato, Cloppenborg-Schmidt, Kunzel, Laudes, Marschall, Lieb, Nothlings, Karlsen, Baines, Franke (CR114) 2016; 48
Coulombe, Langlois, De Palma, Langlois, McCarville, Gagne-Sanfacon, Perreault, Feng, Bercik, Boudreau, Verdu, Rivard (CR14) 2016; 231
Yang, Liu, Zhao, He, Ding, Dai, Xu, Xiao, Luo, Liu, Li, Meng (CR124) 2018
Liu, Zhou, Du, Sun, Wang, Wang, Li, Yu, Song, Bai, Xin, Wu, Jiang, Feng, Xiang, Zhou, Ma, Wang, Liu, Liu (CR71) 2020; 11
Georgopoulos, Bigby, Wang, Molnar, Wu, Winandy, Sharpe (CR31) 1994; 79
Dong, Gupta (CR24) 2019; 17
Desbonnet, Clarke, Shanahan, Dinan, Cryan (CR20) 2014; 19
Goodrich, Davenport, Beaumont, Jackson, Knight, Ober, Spector, Bell, Clark, Ley (CR35) 2016; 19
Zheng, Zeng, Zhou, Liu, Fang, Xu, Zeng, Chen, Fan, Du, Zhang, Yang, Yang, Meng, Li, Melgiri, Licinio, Wei, Xie (CR127) 2016; 21
Org, Parks, Joo, Emert, Schwartzman, Kang, Mehrabian, Pan, Knight, Gunsalus, Drake, Eskin, Lusis (CR79) 2015; 25
Lee-Sarwar, Lasky-Su, Kelly, Litonjua, Weiss (CR65) 2020; 10
Cryan, O'Riordan, Cowan, Sandhu, Bastiaanssen, Boehme, Codagnone, Cussotto, Fulling, Golubeva, Guzzetta, Jaggar, Long-Smith, Lyte, Martin, Molinero-Perez, Moloney, Morelli, Morillas, O'Connor, Cruz-Pereira, Peterson, Rea, Ritz, Sherwin, Spichak, Teichman, van de Wouw, Ventura-Silva, Wallace-Fitzsimons, Hyland, Clarke, Dinan (CR17) 2019; 99
Krych, Hansen, Hansen, van den Berg, Nielsen (CR58) 2013; 8
Niska-Blakie, Gopinathan, Low, Kien, Goh, Caldez, Pfeiffenberger, Jones, Ong, Kurochkin, Coppola, Tessarollo, Choi, Kanagasundaram, Eisenhaber, Maurer-Stroh, Kaldis (CR78) 2020; 77
Vaishnava, Yamamoto, Severson, Ruhn, Yu, Koren, Ley, Wakeland, Hooper (CR108) 2011; 334
Brandt (CR7) 2012; 8
Davie (CR19) 2003; 133
Li, Chen, Yuan, Chen, Du, Wan (CR67) 2020; 79
Frohlich, Farzi, Mayerhofer, Reichmann, Jacan, Wagner, Zinser, Bordag, Magnes, Frohlich, Kashofer, Gorkiewicz, Holzer (CR29) 2016; 56
Chassaing, Ley, Gewirtz (CR12) 2014; 147
Neufeld, Kang, Bienenstock, Foster (CR77) 2011; 23
Kemis, Linke, Barrett, Boehm, Traeger, Keller, Rabaglia, Schueler, Stapleton, Gatti, Churchill, Amador-Noguez, Russell, Yandell, Broman, Coon, Attie, Rey (CR53) 2019; 15
Wacklin, Makivuokko, Alakulppi, Nikkila, Tenkanen, Rabina, Partanen, Aranko, Matto (CR111) 2011; 6
Bonder, Kurilshikov, Tigchelaar, Mujagic, Imhann, Vila, Deelen, Vatanen, Schirmer, Smeekens, Zhernakova, Jankipersadsing, Jaeger, Oosting, Cenit, Masclee, Swertz, Li, Kumar, Joosten, Harmsen, Weersma, Franke, Hofker, Xavier, Jonkers, Netea, Wijmenga, Fu, Zhernakova (CR6) 2016; 48
Perry, Bello, Smith (CR82) 2020; 49
Sampson, Debelius, Thron, Janssen, Shastri, Ilhan, Challis, Schretter, Rocha, Gradinaru, Chesselet, Keshavarzian, Shannon, Krajmalnik-Brown, Wittung-Stafshede, Knight, Mazmanian (CR92) 2016; 167
Xiao, Feng, Liang, Sonne, Xia, Qiu, Li, Long, Zhang, Zhang, Liu, Fang, Chou, Glanville, Hao, Kotowska, Colding, Licht, Wu, Yu, Sung, Liang, Li, Jia, Lan, Tremaroli, Dworzynski, Nielsen, Backhed, Dore, Le Chatelier, Ehrlich, Lin, Arumugam, Wang, Madsen, Kristiansen (CR122) 2015; 33
van Opstal, Bordenstein (CR109) 2015; 349
Bauerl, Collado, Diaz Cuevas, Vina, Perez Martinez (CR2) 2018; 66
Wei, Shinkura, Doi, Maruya, Fagarasan, Honjo (CR115) 2011; 12
Truax, Chen, Tam, Cheng, Guo, Koblansky, Chou, Wilson, Brickey, Petrucelli, Liu, Cooper, Koenigsknecht, Young, Netea, Stienstra, Sartor, Montgomery, Coleman, Ting (CR104) 2018; 24
Krautkramer, Fan, Backhed (CR57) 2021; 19
Dudbridge, Gusnanto (CR25) 2008; 32
Wilkins, Monga, Miller (CR118) 2019; 9
Shreiner, Kao, Young (CR97) 2015; 31
Frank, Robertson, Hamm, Kpadeh, Zhang, Chen, Zhu, Sartor, Boedeker, Harpaz, Pace, Li (CR28) 2011; 17
Hooper, Gordon (CR43) 2001; 292
Tam, Patel, Turcotte, Bosse, Pare, Meyre (CR103) 2019; 20
Matsuo, Nagakubo, Yamamoto, Shigeta, Tomida, Fujita, Hirata, Tsunoda, Nakayama, Yoshie (CR74) 2018; 200
Yang, Fu, Liao, Li (CR125) 2020; 293
Gomez, Luckey, Yeoman, Marietta, Berg Miller, Murray, White, Taneja (CR34) 2012; 7
Wen, Ley, Volchkov, Stranges, Avanesyan, Stonebraker, Hu, Wong, Szot, Bluestone, Gordon, Chervonsky (CR116) 2008; 455
Kurilshikov, Medina-Gomez, Bacigalupe, Radjabzadeh, Wang, Demirkan, Le Roy, Raygoza Garay, Finnicum, Liu, Zhernakova, Bonder, Hansen, Frost, Ruhlemann, Turpin, Moon, Kim, Lull, Barkan, Shah, Fornage, Szopinska-Tokov, Wallen, Borisevich, Agreus, Andreasson, Bang, Bedrani, Bell, Bisgaard, Boehnke, Boomsma, Burk, Claringbould, Croitoru, Davies, van Duijn, Duijts, Falony, Fu, van der Graaf, Hansen, Homuth, Hughes, Ijzerman, Jackson, Jaddoe, Joossens, Jorgensen, Keszthelyi, Knight, Laakso, Laudes, Launer, Lieb, Lusis, Masclee, Moll, Mujagic, Qibin, Rothschild, Shin, Sorensen, Steves, Thorsen, Timpson, Tito, Vieira-Silva, Volker, Volzke, Vosa, Wade, Walter, Watanabe, Weiss, Weiss, Weissbrod, Westra, Willemsen, Payami, Jonkers, Arias Vasquez, de Geus, Meyer, Stokholm, Segal, Org, Wijmenga, Kim, Kaplan, Spector, Uitterlinden, Rivadeneira, Franke, Lerch, Franke, Sanna, D'Amato, Pedersen, Paterson, Kraaij, Raes, Zhernakova (CR59) 2021; 53
(CR48) 2004; 431
(CR46) 2012; 486
Di Ciaula, Stella, Bonfrate, Wang, Portincasa (CR21) 2020; 11
Couturier-Maillard, Secher, Rehman, Normand, De Arcangelis, Haesler, Huot, Grandjean, Bressenot, Delanoye-Crespin, Gaillot, Schreiber, Lemoine, Ryffel, Hot, Nunez, Chen, Rosenstiel, Chamaillard (CR15) 2013; 123
Rehman, Sina, Gavrilova, Hasler, Ott, Baines, Schreiber, Rosenstiel (CR87) 2011; 60
Zhou, Gao, Mihindukulasuriya, La Rosa, Wylie, Vishnivetskaya, Podar, Warner, Tarr, Nelson, Fortenberry, Holland, Burr, Shannon, Sodergren, Weinstock (CR128) 2013; 14
Jin, Wu, Zhang, Lu, Xia, Dong, Sun (CR51) 2015; 37
Lim, You, Yoon, Kwon, Lee, Lee, Song, Lee, Sung, Ko (CR68) 2017; 66
Wang, Kalyan, Steck, Turner, Harr, Kunzel, Vallier, Hasler, Franke, Oberg, Ibrahim, Grassl, Kabelitz, Baines (CR113) 2015; 6
Suzuki, Phifer-Rixey, Mack, Sheehan, Lin, Bi, Nachman (CR101) 2019; 28
Rallabhandi, Awomoyi, Thomas, Phalipon, Fujimoto, Fukase, Kusumoto, Qureshi, Sztein, Vogel (CR85) 2008; 180
Liu, Yan, Liu, Wang, Li, Deng, Singh, Coleman, Rodgers (CR70) 2010; 107
McKnite, Perez-Munoz, Lu, Williams, Brewer, Andreux, Bastiaansen, Wang, Kachman, Auwerx, Williams, Benson, Peterson, Ciobanu (CR75) 2012; 7
Hughes, Bacigalupe, Wang, Ruhlemann, Tito, Falony, Joossens, Vieira-Silva, Henckaerts, Rymenans, Verspecht, Ring, Franke, Wade, Timpson, Raes (CR45) 2020; 5
Le Roy, Beaumont, Jackson, Steves, Spector, Bell (CR63) 2018; 9
Elinav, Strowig, Kau, Henao-Mejia, Thaiss, Booth, Peaper, Bertin, Eisenbarth, Gordon, Flavell (CR26) 2011; 145
Xie, Guo, Zhong, Feng, Lan, Qin, Ward, Jackson, Xia, Chen, Chen, Xia, Xu, Li, Xu, Al-Aama, Yang, Wang, Kristiansen, Wang, Steves, Bell, Li, Spector, Jia (CR123) 2016; 3
Benson, Kelly, Legge, Ma, Low, Kim, Zhang, Oh, Nehrenberg, Hua, Kachman, Moriyama, Walter, Peterson, Pomp (CR4) 2010; 107
Laposky, Bradley, Williams, Bass, Turek (CR62) 2008; 295
Turnbaugh, Backhed, Fulton, Gordon (CR105) 2008; 3
Houben, Penders, Oligschlaeger, Dos Reis, Bonder, Koonen, Fu, Hofker, Shiri-Sverdlov (CR44) 2019; 9
Grice, Segre (CR39) 2012; 13
Furusawa, Obata, Fukuda, Endo, Nakato, Takahashi, Nakanishi, Uetake, Kato, Kato, Takahashi, Fukuda, Murakami, Miyauchi, Hino, Atarashi, Onawa, Fujimura, Lockett, Clarke, Topping, Tomita, Hori, Ohara, Morita, Koseki, Kikuchi, Honda, Hase, Ohno (CR30) 2013; 504
Cresci, Thangaraju, Mellinger, Liu, Ganapathy (CR16) 2010; 14
Davenport, Cusanovich, Michelini, Barreiro, Ober, Gilad (CR18) 2015; 10
Wilcox, McGovern, Hecht (CR117) 2020
Saul, Philip, Reinholdt, Chesler (CR93) 2019; 35
Sender, Fuchs, Milo (CR96) 2016; 164
Vijay-Kumar, Aitken, Carvalho, Cullender, Mwangi, Srinivasan, Sitaraman, Knight, Ley, Gewirtz (CR110) 2010; 328
Perez-Munoz, McKnite, Williams, Auwerx, Williams, Peterson, Ciobanu (CR81) 2019; 14
Blekhman, Goodrich, Huang, Sun, Bukowski, Bell, Spector, Keinan, Ley, Gevers, Clark (CR5) 2015; 16
Svenson, Gatti, Valdar, Welsh, Cheng, Chesler, Palmer, McMillan, Churchill (CR102) 2012; 190
Wu, Hashimoto-Hill, Woo, Eshleman, Whitt, Engleman, Karns, Denson, Haslam, Alenghat (CR121) 2020; 586
Hildebrandt, Hoffmann, Sherrill-Mix, Keilbaugh, Hamady, Chen, Knight, Ahima, Bushman, Wu (CR41) 2009; 137
Kadosh, Snir-Alkalay, Venkatachalam, May, Lasry, Elyada, Zinger, Shaham, Vaalani, Mernberger, Stiewe, Pikarsky, Oren, Ben-Neriah (CR52) 2020; 586
Goodrich, Waters, Poole, Sutter, Koren, Blekhman, Beaumont, Van Treuren, Knight, Bell, Spector, Clark, Ley (CR36) 2014; 159
Wolf, Daft, Tanner, Hartmann, Khafipour, Lorenz (CR120) 2014; 62
Hillhouse, Myles, Taylor, Bryda, Franklin (CR42) 2011; 22
Backhed, Ley, Sonnenburg, Peterson, Gordon (CR1) 2005; 307
Ivanov, Atarashi, Manel, Brodie, Shima, Karaoz, Wei, Goldfarb, Santee, Lynch, Tanoue, Imaoka, Itoh, Takeda, Umesaki, Honda, Littman (CR50) 2009; 139
Lamas, Richard, Leducq, Pham, Michel, Da Costa, Bridonneau, Jegou, Hoffmann, Natividad, Brot, Taleb, Couturier-Maillard, Nion-Larmurier, Merabtene, Seksik, Bourrier, Cosnes, Ryffel, Beaugerie, Launay, Langella, Xavier, Sokol (CR61) 2016; 22
Leamy, Kelly, Nietfeldt, Legge, Ma, Hua, Sinha, Peterson, Walter, Benson, Pomp (CR64) 2014; 15
Ley, Backhed, Turnbaugh, Lozupone, Knight, Gordon (CR66) 2005; 102
Hedrich (CR40) 2012
Rothschild, Weissbrod, Barkan, Kurilshikov, Korem, Zeevi, Costea, Godneva, Kalka, Bar, Shilo, Lador, Vila, Zmora, Pevsner-Fischer, Israeli, Kosower, Malka, Wolf, Avnit-Sagi, Lotan-Pompan, Weinberger, Halpern, Carmi, Fu, Wijmenga, Zhernakova, Elinav, Segal (CR89) 2018; 555
Goto, Obata, Kunisawa, Sato, Ivanov, Lamichhane, Takeyama, Kamioka, Sakamoto, Matsuki, Setoyama, Imaoka, Uematsu, Akira, Domino, Kulig, Becher, Renauld, Sasakawa, Umesaki, Benno, Kiyono (CR38) 2014; 345
Scher, Sczesnak, Longman, Segata, Ubeda, Bielski, Rostron, Cerundolo, Pamer, Abramson, Huttenhower, Littman (CR95) 2013; 2
Knight
CL Wilson (9884_CR119) 1999; 286
LJ Wilkins (9884_CR118) 2019; 9
JK Goodrich (9884_CR35) 2016; 19
JK Goodrich (9884_CR36) 2014; 159
PJ Turnbaugh (9884_CR105) 2008; 3
C Mouse Genome Sequencing (9884_CR76) 2002; 420
EJ van Opstal (9884_CR109) 2015; 349
VK Ridaura (9884_CR88) 2013; 341
LJ Brandt (9884_CR7) 2012; 8
Y Furusawa (9884_CR30) 2013; 504
J Wang (9884_CR113) 2015; 6
MJ Bonder (9884_CR6) 2016; 48
P Zheng (9884_CR127) 2016; 21
AD Truax (9884_CR104) 2018; 24
K Suzuki (9884_CR100) 2004; 101
A Kurilshikov (9884_CR59) 2021; 53
F Backhed (9884_CR1) 2005; 307
TS Dong (9884_CR24) 2019; 17
K Georgopoulos (9884_CR31) 1994; 79
PJ Turnbaugh (9884_CR106) 2009; 457
L Krych (9884_CR58) 2013; 8
L Geurts (9884_CR32) 2011; 2
MY Lim (9884_CR68) 2017; 66
WH Liu (9884_CR69) 2016; 298
NH Salzman (9884_CR91) 2010; 11
D Jin (9884_CR51) 2015; 37
A Rehman (9884_CR87) 2011; 60
L Xiao (9884_CR122) 2015; 33
KM Neufeld (9884_CR77) 2011; 23
DA Hughes (9884_CR45) 2020; 5
AM Caricilli (9884_CR11) 2011; 9
W Liu (9884_CR70) 2010; 107
B Chassaing (9884_CR12) 2014; 147
M Beaumont (9884_CR3) 2016; 17
CI Le Roy (9884_CR63) 2018; 9
JR Davie (9884_CR19) 2003; 133
H Xie (9884_CR123) 2016; 3
KA Krautkramer (9884_CR56) 2017; 189
J Wang (9884_CR114) 2016; 48
S Saha (9884_CR90) 2010; 8
HJ Hedrich (9884_CR40) 2012
G Clarke (9884_CR13) 2013; 18
SR Gill (9884_CR33) 2006; 312
V Tam (9884_CR103) 2019; 20
SE Wu (9884_CR121) 2020; 586
MC Saul (9884_CR93) 2019; 35
P Pozzilli (9884_CR84) 1993; 14
GA Cresci (9884_CR16) 2010; 14
I Pierantonelli (9884_CR83) 2017; 7
P Rallabhandi (9884_CR85) 2008; 180
Y Zhou (9884_CR128) 2013; 14
G Schepici (9884_CR94) 2019; 28
A Gomez (9884_CR34) 2012; 7
KL Svenson (9884_CR102) 2012; 190
K Matsuo (9884_CR74) 2018; 200
C Liu (9884_CR71) 2020; 11
E Elinav (9884_CR26) 2011; 145
D Knights (9884_CR55) 2014; 6
L Yang (9884_CR124) 2018
A Di Ciaula (9884_CR21) 2020; 11
II Ivanov (9884_CR50) 2009; 139
B Lamas (9884_CR61) 2016; 22
M Vijay-Kumar (9884_CR110) 2010; 328
AM McKnite (9884_CR75) 2012; 7
P Wacklin (9884_CR111) 2011; 6
C Bauerl (9884_CR2) 2018; 66
D Rothschild (9884_CR89) 2018; 555
MG Dominguez-Bello (9884_CR23) 2010; 107
DN Frank (9884_CR28) 2011; 17
E Org (9884_CR79) 2015; 25
PA Engen (9884_CR27) 2020; 11
EE Frohlich (9884_CR29) 2016; 56
AD Laposky (9884_CR62) 2008; 295
KA Lee-Sarwar (9884_CR65) 2020; 10
JA Bubier (9884_CR9) 2020; 214
LV Hooper (9884_CR43) 2001; 292
R Blekhman (9884_CR5) 2015; 16
I Lagkouvardos (9884_CR60) 2016; 1
TA Manolio (9884_CR73) 2009; 461
J Niska-Blakie (9884_CR78) 2020; 77
Human Microbiome Project C (9884_CR46) 2012; 486
RE Ley (9884_CR66) 2005; 102
S Vaishnava (9884_CR108) 2011; 334
ZA Khachatryan (9884_CR54) 2008; 3
TA Suzuki (9884_CR101) 2019; 28
T Houben (9884_CR44) 2019; 9
Y Li (9884_CR67) 2020; 79
AB Shreiner (9884_CR97) 2015; 31
Y Goto (9884_CR38) 2014; 345
AE Hillhouse (9884_CR42) 2011; 22
ER Davenport (9884_CR18) 2015; 10
L Desbonnet (9884_CR20) 2014; 19
J Suez (9884_CR99) 2014; 514
LJ Leamy (9884_CR64) 2014; 15
KJ Wolf (9884_CR120) 2014; 62
JH Kemis (9884_CR53) 2019; 15
G Coulombe (9884_CR14) 2016; 231
E Kadosh (9884_CR52) 2020; 586
A Couturier-Maillard (9884_CR15) 2013; 123
M Wei (9884_CR115) 2011; 12
F Brodziak (9884_CR8) 2013; 8
KA Krautkramer (9884_CR57) 2021; 19
AM Snijders (9884_CR98) 2016; 2
G Gorkiewicz (9884_CR37) 2018; 472
ME Perez-Munoz (9884_CR81) 2019; 14
J Yang (9884_CR125) 2020; 293
MA Hildebrandt (9884_CR41) 2009; 137
JF Cryan (9884_CR17) 2019; 99
F Dudbridge (9884_CR25) 2008; 32
S Ishida (9884_CR49) 2020; 3
JU Scher (9884_CR95) 2013; 2
MH Wilcox (9884_CR117) 2020
L Wen (9884_CR116) 2008; 455
A Lundin (9884_CR72) 2008; 10
J Walter (9884_CR112) 2020; 180
R Diaz Heijtz (9884_CR22) 2011; 108
D Oz-Levi (9884_CR80) 2019; 571
JH Campbell (9884_CR10) 2012; 6
EA Grice (9884_CR39) 2012; 13
MN Perry (9884_CR82) 2020; 49
P Rausch (9884_CR86) 2011; 108
R Sender (9884_CR96) 2016; 164
AK Benson (9884_CR4) 2010; 107
W Turpin (9884_CR107) 2016; 48
TR Sampson (9884_CR92) 2016; 167
SM Huse (9884_CR47) 2012; 7
C Zhang (9884_CR126) 2010; 4
International Human Genome Sequencing C (9884_CR48) 2004; 431
References_xml – volume: 28
  start-page: 3197
  year: 2019
  end-page: 3207
  ident: CR101
  article-title: Host genetic determinants of the gut microbiota of wild mice
  publication-title: Mol Ecol
  doi: 10.1111/mec.15139
– volume: 9
  start-page: 12918
  year: 2019
  ident: CR118
  article-title: Defining dysbiosis for a cluster of chronic diseases
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-49452-y
– volume: 19
  start-page: 146
  year: 2014
  end-page: 148
  ident: CR20
  article-title: Microbiota is essential for social development in the mouse
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.65
– volume: 7
  start-page: e39191
  year: 2012
  ident: CR75
  article-title: Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039191
– volume: 60
  start-page: 1354
  year: 2011
  end-page: 1362
  ident: CR87
  article-title: Nod2 is essential for temporal development of intestinal microbial communities
  publication-title: Gut
  doi: 10.1136/gut.2010.216259
– volume: 341
  start-page: 1241214
  year: 2013
  ident: CR88
  article-title: Gut microbiota from twins discordant for obesity modulate metabolism in mice
  publication-title: Science
  doi: 10.1126/science.1241214
– volume: 13
  start-page: 151
  year: 2012
  end-page: 170
  ident: CR39
  article-title: The human microbiome: our second genome
  publication-title: Annu Rev Genom Hum Genet
  doi: 10.1146/annurev-genom-090711-163814
– volume: 77
  start-page: 3423
  year: 2020
  end-page: 3439
  ident: CR78
  article-title: Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-019-03359-z
– volume: 19
  start-page: 77
  year: 2021
  end-page: 94
  ident: CR57
  article-title: Gut microbial metabolites as multi-kingdom intermediates
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-020-0438-4
– volume: 586
  start-page: 133
  year: 2020
  end-page: 138
  ident: CR52
  article-title: The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
  publication-title: Nature
  doi: 10.1038/s41586-020-2541-0
– volume: 17
  start-page: 189
  year: 2016
  ident: CR3
  article-title: Heritable components of the human fecal microbiome are associated with visceral fat
  publication-title: Genome Biol
  doi: 10.1186/s13059-016-1052-7
– volume: 3
  start-page: e3064
  year: 2008
  ident: CR54
  article-title: Predominant role of host genetics in controlling the composition of gut microbiota
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0003064
– volume: 18
  start-page: 666
  year: 2013
  end-page: 673
  ident: CR13
  article-title: The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2012.77
– volume: 6
  start-page: 6440
  year: 2015
  ident: CR113
  article-title: Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome
  publication-title: Nat Commun
  doi: 10.1038/ncomms7440
– volume: 214
  start-page: 719
  year: 2020
  end-page: 733
  ident: CR9
  article-title: A microbe associated with sleep revealed by a novel systems genetic analysis of the microbiome in collaborative cross mice
  publication-title: Genetics
  doi: 10.1534/genetics.119.303013
– volume: 16
  start-page: 191
  year: 2015
  ident: CR5
  article-title: Host genetic variation impacts microbiome composition across human body sites
  publication-title: Genome Biol
  doi: 10.1186/s13059-015-0759-1
– volume: 3
  start-page: 686
  year: 2020
  ident: CR49
  article-title: Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota
  publication-title: Commun Biol
  doi: 10.1038/s42003-020-01416-z
– volume: 8
  start-page: e72317
  year: 2013
  ident: CR8
  article-title: Differences in mucosal gene expression in the colon of two inbred mouse strains after colonization with commensal gut bacteria
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0072317
– volume: 66
  start-page: 464
  year: 2018
  end-page: 471
  ident: CR2
  article-title: Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan
  publication-title: Lett Appl Microbiol
  doi: 10.1111/lam.12882
– volume: 312
  start-page: 1355
  year: 2006
  end-page: 1359
  ident: CR33
  article-title: Metagenomic analysis of the human distal gut microbiome
  publication-title: Science
  doi: 10.1126/science.1124234
– volume: 133
  start-page: 2485S
  year: 2003
  end-page: 2493S
  ident: CR19
  article-title: Inhibition of histone deacetylase activity by butyrate
  publication-title: J Nutr
  doi: 10.1093/jn/133.7.2485S
– volume: 14
  start-page: e0224100
  year: 2019
  ident: CR81
  article-title: Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0224100
– volume: 66
  start-page: 1031
  year: 2017
  end-page: 1038
  ident: CR68
  article-title: The effect of heritability and host genetics on the gut microbiota and metabolic syndrome
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-311326
– volume: 7
  start-page: e34242
  year: 2012
  ident: CR47
  article-title: A core human microbiome as viewed through 16S rRNA sequence clusters
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0034242
– volume: 571
  start-page: 107
  year: 2019
  end-page: 111
  ident: CR80
  article-title: Noncoding deletions reveal a gene that is critical for intestinal function
  publication-title: Nature
  doi: 10.1038/s41586-019-1312-2
– volume: 9
  start-page: e1001212
  year: 2011
  ident: CR11
  article-title: Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1001212
– volume: 6
  start-page: 107
  year: 2014
  ident: CR55
  article-title: Complex host genetics influence the microbiome in inflammatory bowel disease
  publication-title: Genome Med
  doi: 10.1186/s13073-014-0107-1
– volume: 17
  start-page: 231
  year: 2019
  end-page: 242
  ident: CR24
  article-title: Influence of early life, diet, and the environment on the microbiome
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2018.08.067
– volume: 79
  start-page: 143
  year: 1994
  end-page: 156
  ident: CR31
  article-title: The Ikaros gene is required for the development of all lymphoid lineages
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90407-3
– volume: 14
  start-page: 449
  year: 2010
  end-page: 461
  ident: CR16
  article-title: Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8
  publication-title: J Gastrointest Surg
  doi: 10.1007/s11605-009-1045-x
– volume: 457
  start-page: 480
  year: 2009
  end-page: 484
  ident: CR106
  article-title: A core gut microbiome in obese and lean twins
  publication-title: Nature
  doi: 10.1038/nature07540
– volume: 298
  start-page: 202
  year: 2016
  end-page: 209
  ident: CR69
  article-title: Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.10.046
– volume: 10
  start-page: e0140301
  year: 2015
  ident: CR18
  article-title: Genome-wide association studies of the human gut microbiota
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0140301
– volume: 10
  start-page: 1093
  year: 2008
  end-page: 1103
  ident: CR72
  article-title: Gut flora, toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine
  publication-title: Cell Microbiol
  doi: 10.1111/j.1462-5822.2007.01108.x
– volume: 139
  start-page: 485
  year: 2009
  end-page: 498
  ident: CR50
  article-title: Induction of intestinal Th17 cells by segmented filamentous bacteria
  publication-title: Cell
  doi: 10.1016/j.cell.2009.09.033
– year: 2020
  ident: CR117
  article-title: The efficacy and safety of fecal microbiota transplant for recurrent clostridiumdifficile infection: current understanding and gap analysis
  publication-title: Open Forum Infect Dis
  doi: 10.1093/ofid/ofaa114
– volume: 22
  start-page: 598
  year: 2016
  end-page: 605
  ident: CR61
  article-title: CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
  publication-title: Nat Med
  doi: 10.1038/nm.4102
– volume: 2
  start-page: 16221
  year: 2016
  ident: CR98
  article-title: Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2016.221
– volume: 108
  start-page: 3047
  year: 2011
  end-page: 3052
  ident: CR22
  article-title: Normal gut microbiota modulates brain development and behavior
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1010529108
– volume: 48
  start-page: 1407
  year: 2016
  end-page: 1412
  ident: CR6
  article-title: The effect of host genetics on the gut microbiome
  publication-title: Nat Genet
  doi: 10.1038/ng.3663
– volume: 295
  start-page: R2059
  year: 2008
  end-page: 2066
  ident: CR62
  article-title: Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00026.2008
– volume: 35
  start-page: 501
  year: 2019
  end-page: 514
  ident: CR93
  article-title: High-diversity mouse populations for complex traits
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2019.04.003
– volume: 292
  start-page: 1115
  year: 2001
  end-page: 1118
  ident: CR43
  article-title: Commensal host-bacterial relationships in the gut
  publication-title: Science
  doi: 10.1126/science.1058709
– year: 2018
  ident: CR124
  article-title: Impaired autophagy in intestinal epithelial cells alters gut microbiota and host immune responses
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00880-18
– volume: 514
  start-page: 181
  year: 2014
  end-page: 186
  ident: CR99
  article-title: Artificial sweeteners induce glucose intolerance by altering the gut microbiota
  publication-title: Nature
  doi: 10.1038/nature13793
– volume: 15
  start-page: e1008073
  year: 2019
  ident: CR53
  article-title: Genetic determinants of gut microbiota composition and bile acid profiles in mice
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1008073
– volume: 19
  start-page: 731
  year: 2016
  end-page: 743
  ident: CR35
  article-title: Genetic determinants of the gut microbiome in UK twins
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.04.017
– volume: 20
  start-page: 467
  year: 2019
  end-page: 484
  ident: CR103
  article-title: Benefits and limitations of genome-wide association studies
  publication-title: Nat Rev Genet
  doi: 10.1038/s41576-019-0127-1
– volume: 25
  start-page: 1558
  year: 2015
  end-page: 1569
  ident: CR79
  article-title: Genetic and environmental control of host-gut microbiota interactions
  publication-title: Genome Res
  doi: 10.1101/gr.194118.115
– volume: 555
  start-page: 210
  year: 2018
  end-page: 215
  ident: CR89
  article-title: Environment dominates over host genetics in shaping human gut microbiota
  publication-title: Nature
  doi: 10.1038/nature25973
– volume: 79
  start-page: 105901
  year: 2020
  ident: CR67
  article-title: Altered microbial community structure in PI3Kgamma knockout mice with colitis impeding relief of inflammation: establishment of new indices for intestinal microbial disorder
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2019.105901
– volume: 123
  start-page: 700
  year: 2013
  end-page: 711
  ident: CR15
  article-title: NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
  publication-title: J Clin Invest
– volume: 7
  start-page: 12200
  year: 2017
  ident: CR83
  article-title: Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-11744-6
– volume: 189
  start-page: 30
  year: 2017
  end-page: 50
  ident: CR56
  article-title: Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin
  publication-title: Transl Res
  doi: 10.1016/j.trsl.2017.08.005
– volume: 3
  start-page: 213
  year: 2008
  end-page: 223
  ident: CR105
  article-title: Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2008.02.015
– volume: 21
  start-page: 786
  year: 2016
  end-page: 796
  ident: CR127
  article-title: Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2016.44
– volume: 56
  start-page: 140
  year: 2016
  end-page: 155
  ident: CR29
  article-title: Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2016.02.020
– volume: 12
  start-page: 264
  year: 2011
  end-page: 270
  ident: CR115
  article-title: Mice carrying a knock-in mutation of aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
  publication-title: Nat Immunol
  doi: 10.1038/ni.1991
– volume: 431
  start-page: 931
  year: 2004
  end-page: 945
  ident: CR48
  article-title: Finishing the euchromatic sequence of the human genome
  publication-title: Nature
  doi: 10.1038/nature03001
– volume: 11
  start-page: 978
  year: 2020
  ident: CR27
  article-title: Single-arm, non-randomized, time series, single-subject study of fecal microbiota transplantation in multiple sclerosis
  publication-title: Front Neurol
  doi: 10.3389/fneur.2020.00978
– volume: 2
  start-page: e01202
  year: 2013
  ident: CR95
  article-title: Expansion of intestinal correlates with enhanced susceptibility to arthritis
  publication-title: Elife
  doi: 10.7554/eLife.01202
– volume: 190
  start-page: 437
  year: 2012
  end-page: 447
  ident: CR102
  article-title: High-resolution genetic mapping using the mouse diversity outbred population
  publication-title: Genetics
  doi: 10.1534/genetics.111.132597
– volume: 37
  start-page: 996
  year: 2015
  end-page: 1009
  ident: CR51
  article-title: Lack of vitamin D receptor causes dysbiosis and changes the functions of the murine intestinal microbiome
  publication-title: Clin Ther
  doi: 10.1016/j.clinthera.2015.04.004
– volume: 11
  start-page: 1041
  issue: 9
  year: 2020
  ident: CR21
  article-title: Gut microbiota between environment and genetic background in familial mediterranean fever (FMF)
  publication-title: Genes
  doi: 10.3390/genes11091041
– volume: 486
  start-page: 207
  year: 2012
  end-page: 214
  ident: CR46
  article-title: Structure, function and diversity of the healthy human microbiome
  publication-title: Nature
  doi: 10.1038/nature11234
– volume: 147
  start-page: 1363
  year: 2014
  end-page: 1377
  ident: CR12
  article-title: Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2014.08.033
– volume: 7
  start-page: e36095
  year: 2012
  ident: CR34
  article-title: Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0036095
– volume: 28
  start-page: 1507
  year: 2019
  end-page: 1527
  ident: CR94
  article-title: The gut microbiota in multiple sclerosis: an overview of clinical trials
  publication-title: Cell Transplant
  doi: 10.1177/0963689719873890
– volume: 2
  start-page: 149
  year: 2011
  ident: CR32
  article-title: Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2011.00149
– volume: 461
  start-page: 747
  year: 2009
  end-page: 753
  ident: CR73
  article-title: Finding the missing heritability of complex diseases
  publication-title: Nature
  doi: 10.1038/nature08494
– volume: 62
  start-page: 237
  year: 2014
  end-page: 250
  ident: CR120
  article-title: Consumption of acidic water alters the gut microbiome and decreases the risk of diabetes in NOD mice
  publication-title: J Histochem Cytochem
  doi: 10.1369/0022155413519650
– volume: 11
  start-page: 79
  year: 2020
  ident: CR71
  article-title: The mouse gut microbial biobank expands the coverage of cultured bacteria
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-13836-5
– volume: 101
  start-page: 1981
  year: 2004
  end-page: 1986
  ident: CR100
  article-title: Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0307317101
– volume: 14
  start-page: 193
  year: 1993
  end-page: 196
  ident: CR84
  article-title: NOD mouse colonies around the world–recent facts and figures
  publication-title: Immunol Today
  doi: 10.1016/0167-5699(93)90160-M
– volume: 17
  start-page: 179
  year: 2011
  end-page: 184
  ident: CR28
  article-title: Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.21339
– volume: 328
  start-page: 228
  year: 2010
  end-page: 231
  ident: CR110
  article-title: Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5
  publication-title: Science
  doi: 10.1126/science.1179721
– volume: 504
  start-page: 446
  year: 2013
  end-page: 450
  ident: CR30
  article-title: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
  publication-title: Nature
  doi: 10.1038/nature12721
– volume: 48
  start-page: 1396
  year: 2016
  end-page: 1406
  ident: CR114
  article-title: Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
  publication-title: Nat Genet
  doi: 10.1038/ng.3695
– volume: 159
  start-page: 789
  year: 2014
  end-page: 799
  ident: CR36
  article-title: Human genetics shape the gut microbiome
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.053
– volume: 586
  start-page: 108
  year: 2020
  end-page: 112
  ident: CR121
  article-title: Microbiota-derived metabolite promotes HDAC3 activity in the gut
  publication-title: Nature
  doi: 10.1038/s41586-020-2604-2
– volume: 137
  start-page: e1711
  issue: 1716–1724
  year: 2009
  end-page: 1712
  ident: CR41
  article-title: High-fat diet determines the composition of the murine gut microbiome independently of obesity
  publication-title: Gastroenterology
– volume: 167
  start-page: 1469
  year: 2016
  end-page: 1480
  ident: CR92
  article-title: Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.018
– volume: 472
  start-page: 159
  year: 2018
  end-page: 172
  ident: CR37
  article-title: Gut microbiome: a new player in gastrointestinal disease
  publication-title: Virchows Arch
  doi: 10.1007/s00428-017-2277-x
– volume: 180
  start-page: 221
  year: 2020
  end-page: 232
  ident: CR112
  article-title: Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents
  publication-title: Cell
  doi: 10.1016/j.cell.2019.12.025
– volume: 8
  start-page: e62578
  year: 2013
  ident: CR58
  article-title: Quantitatively different, yet qualitatively alike: a meta-analysis of the mouse core gut microbiome with a view towards the human gut microbiome
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0062578
– volume: 24
  start-page: 364
  year: 2018
  end-page: 378
  ident: CR104
  article-title: The inhibitory innate immune sensor nlrp12 maintains a threshold against obesity by regulating gut microbiota homeostasis
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.08.009
– volume: 4
  start-page: 232
  year: 2010
  end-page: 241
  ident: CR126
  article-title: Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
  publication-title: ISME J
  doi: 10.1038/ismej.2009.112
– volume: 164
  start-page: 337
  year: 2016
  end-page: 340
  ident: CR96
  article-title: Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans
  publication-title: Cell
  doi: 10.1016/j.cell.2016.01.013
– volume: 99
  start-page: 1877
  year: 2019
  end-page: 2013
  ident: CR17
  article-title: The microbiota-gut-brain axis
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00018.2018
– volume: 23
  start-page: 255
  year: 2011
  end-page: 264
  ident: CR77
  article-title: Reduced anxiety-like behavior and central neurochemical change in germ-free mice
  publication-title: Neurogastroenterol Motil
  doi: 10.1111/j.1365-2982.2010.01620.x
– volume: 53
  start-page: 156
  year: 2021
  end-page: 165
  ident: CR59
  article-title: Large-scale association analyses identify host factors influencing human gut microbiome composition
  publication-title: Nat Genet
  doi: 10.1038/s41588-020-00763-1
– volume: 31
  start-page: 69
  year: 2015
  end-page: 75
  ident: CR97
  article-title: The gut microbiome in health and in disease
  publication-title: Curr Opin Gastroenterol
  doi: 10.1097/MOG.0000000000000139
– volume: 6
  start-page: e20113
  year: 2011
  ident: CR111
  article-title: Secretor genotype (FUT2 gene) is strongly associated with the composition of in the human intestine
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0020113
– volume: 307
  start-page: 1915
  year: 2005
  end-page: 1920
  ident: CR1
  article-title: Host-bacterial mutualism in the human intestine
  publication-title: Science
  doi: 10.1126/science.1104816
– volume: 48
  start-page: 1413
  year: 2016
  end-page: 1417
  ident: CR107
  article-title: Association of host genome with intestinal microbial composition in a large healthy cohort
  publication-title: Nat Genet
  doi: 10.1038/ng.3693
– volume: 180
  start-page: 1139
  year: 2008
  end-page: 1147
  ident: CR85
  article-title: Differential activation of human TLR4 by and 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.2.1139
– volume: 9
  start-page: 14956
  year: 2019
  ident: CR44
  article-title: Hematopoietic Npc1 mutation shifts gut microbiota composition in Ldlr(-/-) mice on a high-fat, high-cholesterol diet
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-51525-x
– volume: 10
  start-page: 181
  issue: 5
  year: 2020
  ident: CR65
  article-title: Metabolome-microbiome crosstalk and human disease
  publication-title: Metabolites
  doi: 10.3390/metabo10050181
– volume: 345
  start-page: 1254009
  year: 2014
  ident: CR38
  article-title: Innate lymphoid cells regulate intestinal epithelial cell glycosylation
  publication-title: Science
  doi: 10.1126/science.1254009
– volume: 200
  start-page: 800
  year: 2018
  end-page: 809
  ident: CR74
  article-title: CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1700037
– volume: 8
  start-page: 191
  year: 2012
  end-page: 194
  ident: CR7
  article-title: Fecal transplantation for the treatment of clostridium difficile infection
  publication-title: Gastroenterol Hepatol
– volume: 5
  start-page: 1079
  year: 2020
  end-page: 1087
  ident: CR45
  article-title: Genome-wide associations of human gut microbiome variation and implications for causal inference analyses
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-020-0743-8
– volume: 107
  start-page: 11971
  year: 2010
  end-page: 11975
  ident: CR23
  article-title: Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1002601107
– volume: 107
  start-page: 11056
  year: 2010
  end-page: 11061
  ident: CR70
  article-title: Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1001269107
– volume: 22
  start-page: 544
  year: 2011
  end-page: 555
  ident: CR42
  article-title: Quantitative trait loci in a bacterially induced model of inflammatory bowel disease
  publication-title: Mamm Genome
  doi: 10.1007/s00335-011-9343-5
– volume: 102
  start-page: 11070
  year: 2005
  end-page: 11075
  ident: CR66
  article-title: Obesity alters gut microbial ecology
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0504978102
– volume: 286
  start-page: 113
  year: 1999
  end-page: 117
  ident: CR119
  article-title: Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
  publication-title: Science
  doi: 10.1126/science.286.5437.113
– volume: 6
  start-page: 2033
  year: 2012
  end-page: 2044
  ident: CR10
  article-title: Host genetic and environmental effects on mouse intestinal microbiota
  publication-title: ISME J
  doi: 10.1038/ismej.2012.54
– year: 2012
  ident: CR40
  publication-title: The laboratory mouse
– volume: 11
  start-page: 76
  year: 2010
  end-page: 83
  ident: CR91
  article-title: Enteric defensins are essential regulators of intestinal microbial ecology
  publication-title: Nat Immunol
  doi: 10.1038/ni.1825
– volume: 334
  start-page: 255
  year: 2011
  end-page: 258
  ident: CR108
  article-title: The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
  publication-title: Science
  doi: 10.1126/science.1209791
– volume: 32
  start-page: 227
  year: 2008
  end-page: 234
  ident: CR25
  article-title: Estimation of significance thresholds for genomewide association scans
  publication-title: Genet Epidemiol
  doi: 10.1002/gepi.20297
– volume: 1
  start-page: 16131
  year: 2016
  ident: CR60
  article-title: The mouse intestinal bacterial collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2016.131
– volume: 145
  start-page: 745
  year: 2011
  end-page: 757
  ident: CR26
  article-title: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
  publication-title: Cell
  doi: 10.1016/j.cell.2011.04.022
– volume: 3
  start-page: 572
  year: 2016
  end-page: 584
  ident: CR123
  article-title: Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome
  publication-title: Cell Syst
  doi: 10.1016/j.cels.2016.10.004
– volume: 49
  start-page: 301
  year: 2020
  end-page: 302
  ident: CR82
  article-title: Know your model: microbiota & phenotypes
  publication-title: Lab Anim
  doi: 10.1038/s41684-020-00660-4
– volume: 293
  start-page: 113471
  year: 2020
  ident: CR125
  article-title: Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: a systematic review
  publication-title: Psychiatry Res
  doi: 10.1016/j.psychres.2020.113471
– volume: 349
  start-page: 1172
  year: 2015
  end-page: 1173
  ident: CR109
  article-title: Rethinking heritability of the microbiome
  publication-title: Science
  doi: 10.1126/science.aab3958
– volume: 108
  start-page: 19030
  year: 2011
  end-page: 19035
  ident: CR86
  article-title: Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1106408108
– volume: 231
  start-page: 2529
  year: 2016
  end-page: 2540
  ident: CR14
  article-title: SHP-2 Phosphatase prevents colonic inflammation by controlling secretory cell differentiation and maintaining host-microbiota homeostasis
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.25407
– volume: 14
  start-page: R1
  year: 2013
  ident: CR128
  article-title: Biogeography of the ecosystems of the healthy human body
  publication-title: Genome Biol
  doi: 10.1186/gb-2013-14-1-r1
– volume: 107
  start-page: 18933
  year: 2010
  end-page: 18938
  ident: CR4
  article-title: Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1007028107
– volume: 9
  start-page: 61
  year: 2018
  end-page: 67
  ident: CR63
  article-title: Heritable components of the human fecal microbiome are associated with visceral fat
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2017.1356556
– volume: 420
  start-page: 520
  year: 2002
  end-page: 562
  ident: CR76
  article-title: Initial sequencing and comparative analysis of the mouse genome
  publication-title: Nature
  doi: 10.1038/nature01262
– volume: 8
  start-page: 147
  year: 2010
  end-page: 162
  ident: CR90
  article-title: Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2010.07.005
– volume: 33
  start-page: 1103
  year: 2015
  end-page: 1108
  ident: CR122
  article-title: A catalog of the mouse gut metagenome
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.3353
– volume: 15
  start-page: 552
  year: 2014
  ident: CR64
  article-title: Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice
  publication-title: Genome Biol
  doi: 10.1186/s13059-014-0552-6
– volume: 455
  start-page: 1109
  year: 2008
  end-page: 1113
  ident: CR116
  article-title: Innate immunity and intestinal microbiota in the development of Type 1 diabetes
  publication-title: Nature
  doi: 10.1038/nature07336
– volume: 14
  start-page: 193
  year: 1993
  ident: 9884_CR84
  publication-title: Immunol Today
  doi: 10.1016/0167-5699(93)90160-M
– volume: 53
  start-page: 156
  year: 2021
  ident: 9884_CR59
  publication-title: Nat Genet
  doi: 10.1038/s41588-020-00763-1
– volume: 231
  start-page: 2529
  year: 2016
  ident: 9884_CR14
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.25407
– volume: 431
  start-page: 931
  year: 2004
  ident: 9884_CR48
  publication-title: Nature
  doi: 10.1038/nature03001
– volume: 16
  start-page: 191
  year: 2015
  ident: 9884_CR5
  publication-title: Genome Biol
  doi: 10.1186/s13059-015-0759-1
– volume: 11
  start-page: 76
  year: 2010
  ident: 9884_CR91
  publication-title: Nat Immunol
  doi: 10.1038/ni.1825
– volume: 12
  start-page: 264
  year: 2011
  ident: 9884_CR115
  publication-title: Nat Immunol
  doi: 10.1038/ni.1991
– volume: 6
  start-page: e20113
  year: 2011
  ident: 9884_CR111
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0020113
– volume: 66
  start-page: 1031
  year: 2017
  ident: 9884_CR68
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-311326
– volume: 20
  start-page: 467
  year: 2019
  ident: 9884_CR103
  publication-title: Nat Rev Genet
  doi: 10.1038/s41576-019-0127-1
– volume: 62
  start-page: 237
  year: 2014
  ident: 9884_CR120
  publication-title: J Histochem Cytochem
  doi: 10.1369/0022155413519650
– volume: 586
  start-page: 108
  year: 2020
  ident: 9884_CR121
  publication-title: Nature
  doi: 10.1038/s41586-020-2604-2
– volume: 79
  start-page: 105901
  year: 2020
  ident: 9884_CR67
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2019.105901
– volume: 3
  start-page: e3064
  year: 2008
  ident: 9884_CR54
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0003064
– volume: 9
  start-page: 12918
  year: 2019
  ident: 9884_CR118
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-49452-y
– volume: 10
  start-page: 1093
  year: 2008
  ident: 9884_CR72
  publication-title: Cell Microbiol
  doi: 10.1111/j.1462-5822.2007.01108.x
– volume: 25
  start-page: 1558
  year: 2015
  ident: 9884_CR79
  publication-title: Genome Res
  doi: 10.1101/gr.194118.115
– volume: 571
  start-page: 107
  year: 2019
  ident: 9884_CR80
  publication-title: Nature
  doi: 10.1038/s41586-019-1312-2
– volume: 48
  start-page: 1396
  year: 2016
  ident: 9884_CR114
  publication-title: Nat Genet
  doi: 10.1038/ng.3695
– volume: 60
  start-page: 1354
  year: 2011
  ident: 9884_CR87
  publication-title: Gut
  doi: 10.1136/gut.2010.216259
– volume: 31
  start-page: 69
  year: 2015
  ident: 9884_CR97
  publication-title: Curr Opin Gastroenterol
  doi: 10.1097/MOG.0000000000000139
– year: 2018
  ident: 9884_CR124
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00880-18
– volume: 35
  start-page: 501
  year: 2019
  ident: 9884_CR93
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2019.04.003
– volume: 101
  start-page: 1981
  year: 2004
  ident: 9884_CR100
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0307317101
– volume: 21
  start-page: 786
  year: 2016
  ident: 9884_CR127
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2016.44
– volume: 2
  start-page: e01202
  year: 2013
  ident: 9884_CR95
  publication-title: Elife
  doi: 10.7554/eLife.01202
– volume: 32
  start-page: 227
  year: 2008
  ident: 9884_CR25
  publication-title: Genet Epidemiol
  doi: 10.1002/gepi.20297
– volume: 79
  start-page: 143
  year: 1994
  ident: 9884_CR31
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90407-3
– volume: 66
  start-page: 464
  year: 2018
  ident: 9884_CR2
  publication-title: Lett Appl Microbiol
  doi: 10.1111/lam.12882
– volume: 190
  start-page: 437
  year: 2012
  ident: 9884_CR102
  publication-title: Genetics
  doi: 10.1534/genetics.111.132597
– volume: 7
  start-page: e36095
  year: 2012
  ident: 9884_CR34
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0036095
– volume: 139
  start-page: 485
  year: 2009
  ident: 9884_CR50
  publication-title: Cell
  doi: 10.1016/j.cell.2009.09.033
– volume: 147
  start-page: 1363
  year: 2014
  ident: 9884_CR12
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2014.08.033
– volume: 28
  start-page: 3197
  year: 2019
  ident: 9884_CR101
  publication-title: Mol Ecol
  doi: 10.1111/mec.15139
– volume: 11
  start-page: 79
  year: 2020
  ident: 9884_CR71
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-13836-5
– volume: 8
  start-page: e72317
  year: 2013
  ident: 9884_CR8
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0072317
– volume: 5
  start-page: 1079
  year: 2020
  ident: 9884_CR45
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-020-0743-8
– volume: 22
  start-page: 598
  year: 2016
  ident: 9884_CR61
  publication-title: Nat Med
  doi: 10.1038/nm.4102
– volume: 486
  start-page: 207
  year: 2012
  ident: 9884_CR46
  publication-title: Nature
  doi: 10.1038/nature11234
– volume: 286
  start-page: 113
  year: 1999
  ident: 9884_CR119
  publication-title: Science
  doi: 10.1126/science.286.5437.113
– volume: 293
  start-page: 113471
  year: 2020
  ident: 9884_CR125
  publication-title: Psychiatry Res
  doi: 10.1016/j.psychres.2020.113471
– volume: 15
  start-page: 552
  year: 2014
  ident: 9884_CR64
  publication-title: Genome Biol
  doi: 10.1186/s13059-014-0552-6
– volume: 14
  start-page: R1
  year: 2013
  ident: 9884_CR128
  publication-title: Genome Biol
  doi: 10.1186/gb-2013-14-1-r1
– volume: 164
  start-page: 337
  year: 2016
  ident: 9884_CR96
  publication-title: Cell
  doi: 10.1016/j.cell.2016.01.013
– volume: 7
  start-page: e39191
  year: 2012
  ident: 9884_CR75
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039191
– volume: 8
  start-page: e62578
  year: 2013
  ident: 9884_CR58
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0062578
– volume: 19
  start-page: 731
  year: 2016
  ident: 9884_CR35
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.04.017
– volume: 6
  start-page: 107
  year: 2014
  ident: 9884_CR55
  publication-title: Genome Med
  doi: 10.1186/s13073-014-0107-1
– volume: 11
  start-page: 1041
  issue: 9
  year: 2020
  ident: 9884_CR21
  publication-title: Genes
  doi: 10.3390/genes11091041
– volume: 159
  start-page: 789
  year: 2014
  ident: 9884_CR36
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.053
– volume: 108
  start-page: 19030
  year: 2011
  ident: 9884_CR86
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1106408108
– volume: 3
  start-page: 213
  year: 2008
  ident: 9884_CR105
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2008.02.015
– volume: 472
  start-page: 159
  year: 2018
  ident: 9884_CR37
  publication-title: Virchows Arch
  doi: 10.1007/s00428-017-2277-x
– volume: 214
  start-page: 719
  year: 2020
  ident: 9884_CR9
  publication-title: Genetics
  doi: 10.1534/genetics.119.303013
– volume: 33
  start-page: 1103
  year: 2015
  ident: 9884_CR122
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.3353
– volume: 18
  start-page: 666
  year: 2013
  ident: 9884_CR13
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2012.77
– volume: 107
  start-page: 18933
  year: 2010
  ident: 9884_CR4
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1007028107
– volume: 457
  start-page: 480
  year: 2009
  ident: 9884_CR106
  publication-title: Nature
  doi: 10.1038/nature07540
– volume: 22
  start-page: 544
  year: 2011
  ident: 9884_CR42
  publication-title: Mamm Genome
  doi: 10.1007/s00335-011-9343-5
– volume: 15
  start-page: e1008073
  year: 2019
  ident: 9884_CR53
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1008073
– volume-title: The laboratory mouse
  year: 2012
  ident: 9884_CR40
– volume: 7
  start-page: 12200
  year: 2017
  ident: 9884_CR83
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-11744-6
– volume: 455
  start-page: 1109
  year: 2008
  ident: 9884_CR116
  publication-title: Nature
  doi: 10.1038/nature07336
– volume: 292
  start-page: 1115
  year: 2001
  ident: 9884_CR43
  publication-title: Science
  doi: 10.1126/science.1058709
– volume: 123
  start-page: 700
  year: 2013
  ident: 9884_CR15
  publication-title: J Clin Invest
– volume: 9
  start-page: 14956
  year: 2019
  ident: 9884_CR44
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-51525-x
– volume: 102
  start-page: 11070
  year: 2005
  ident: 9884_CR66
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0504978102
– volume: 420
  start-page: 520
  year: 2002
  ident: 9884_CR76
  publication-title: Nature
  doi: 10.1038/nature01262
– volume: 37
  start-page: 996
  year: 2015
  ident: 9884_CR51
  publication-title: Clin Ther
  doi: 10.1016/j.clinthera.2015.04.004
– volume: 349
  start-page: 1172
  year: 2015
  ident: 9884_CR109
  publication-title: Science
  doi: 10.1126/science.aab3958
– volume: 48
  start-page: 1413
  year: 2016
  ident: 9884_CR107
  publication-title: Nat Genet
  doi: 10.1038/ng.3693
– volume: 8
  start-page: 191
  year: 2012
  ident: 9884_CR7
  publication-title: Gastroenterol Hepatol
– volume: 24
  start-page: 364
  year: 2018
  ident: 9884_CR104
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.08.009
– volume: 14
  start-page: e0224100
  year: 2019
  ident: 9884_CR81
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0224100
– volume: 2
  start-page: 149
  year: 2011
  ident: 9884_CR32
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2011.00149
– volume: 555
  start-page: 210
  year: 2018
  ident: 9884_CR89
  publication-title: Nature
  doi: 10.1038/nature25973
– volume: 19
  start-page: 146
  year: 2014
  ident: 9884_CR20
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.65
– volume: 514
  start-page: 181
  year: 2014
  ident: 9884_CR99
  publication-title: Nature
  doi: 10.1038/nature13793
– volume: 1
  start-page: 16131
  year: 2016
  ident: 9884_CR60
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2016.131
– volume: 200
  start-page: 800
  year: 2018
  ident: 9884_CR74
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1700037
– volume: 107
  start-page: 11971
  year: 2010
  ident: 9884_CR23
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1002601107
– volume: 48
  start-page: 1407
  year: 2016
  ident: 9884_CR6
  publication-title: Nat Genet
  doi: 10.1038/ng.3663
– volume: 461
  start-page: 747
  year: 2009
  ident: 9884_CR73
  publication-title: Nature
  doi: 10.1038/nature08494
– volume: 189
  start-page: 30
  year: 2017
  ident: 9884_CR56
  publication-title: Transl Res
  doi: 10.1016/j.trsl.2017.08.005
– volume: 307
  start-page: 1915
  year: 2005
  ident: 9884_CR1
  publication-title: Science
  doi: 10.1126/science.1104816
– volume: 312
  start-page: 1355
  year: 2006
  ident: 9884_CR33
  publication-title: Science
  doi: 10.1126/science.1124234
– volume: 3
  start-page: 572
  year: 2016
  ident: 9884_CR123
  publication-title: Cell Syst
  doi: 10.1016/j.cels.2016.10.004
– volume: 328
  start-page: 228
  year: 2010
  ident: 9884_CR110
  publication-title: Science
  doi: 10.1126/science.1179721
– volume: 133
  start-page: 2485S
  year: 2003
  ident: 9884_CR19
  publication-title: J Nutr
  doi: 10.1093/jn/133.7.2485S
– volume: 145
  start-page: 745
  year: 2011
  ident: 9884_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2011.04.022
– volume: 13
  start-page: 151
  year: 2012
  ident: 9884_CR39
  publication-title: Annu Rev Genom Hum Genet
  doi: 10.1146/annurev-genom-090711-163814
– volume: 23
  start-page: 255
  year: 2011
  ident: 9884_CR77
  publication-title: Neurogastroenterol Motil
  doi: 10.1111/j.1365-2982.2010.01620.x
– volume: 8
  start-page: 147
  year: 2010
  ident: 9884_CR90
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2010.07.005
– volume: 19
  start-page: 77
  year: 2021
  ident: 9884_CR57
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-020-0438-4
– volume: 4
  start-page: 232
  year: 2010
  ident: 9884_CR126
  publication-title: ISME J
  doi: 10.1038/ismej.2009.112
– volume: 10
  start-page: e0140301
  year: 2015
  ident: 9884_CR18
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0140301
– volume: 56
  start-page: 140
  year: 2016
  ident: 9884_CR29
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2016.02.020
– volume: 10
  start-page: 181
  issue: 5
  year: 2020
  ident: 9884_CR65
  publication-title: Metabolites
  doi: 10.3390/metabo10050181
– volume: 77
  start-page: 3423
  year: 2020
  ident: 9884_CR78
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-019-03359-z
– volume: 298
  start-page: 202
  year: 2016
  ident: 9884_CR69
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.10.046
– volume: 49
  start-page: 301
  year: 2020
  ident: 9884_CR82
  publication-title: Lab Anim
  doi: 10.1038/s41684-020-00660-4
– volume: 295
  start-page: R2059
  year: 2008
  ident: 9884_CR62
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00026.2008
– volume: 107
  start-page: 11056
  year: 2010
  ident: 9884_CR70
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1001269107
– volume: 180
  start-page: 1139
  year: 2008
  ident: 9884_CR85
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.2.1139
– volume: 17
  start-page: 179
  year: 2011
  ident: 9884_CR28
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.21339
– volume: 14
  start-page: 449
  year: 2010
  ident: 9884_CR16
  publication-title: J Gastrointest Surg
  doi: 10.1007/s11605-009-1045-x
– volume: 17
  start-page: 231
  year: 2019
  ident: 9884_CR24
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2018.08.067
– volume: 341
  start-page: 1241214
  year: 2013
  ident: 9884_CR88
  publication-title: Science
  doi: 10.1126/science.1241214
– volume: 28
  start-page: 1507
  year: 2019
  ident: 9884_CR94
  publication-title: Cell Transplant
  doi: 10.1177/0963689719873890
– volume: 345
  start-page: 1254009
  year: 2014
  ident: 9884_CR38
  publication-title: Science
  doi: 10.1126/science.1254009
– volume: 9
  start-page: e1001212
  year: 2011
  ident: 9884_CR11
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1001212
– volume: 99
  start-page: 1877
  year: 2019
  ident: 9884_CR17
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00018.2018
– volume: 586
  start-page: 133
  year: 2020
  ident: 9884_CR52
  publication-title: Nature
  doi: 10.1038/s41586-020-2541-0
– volume: 9
  start-page: 61
  year: 2018
  ident: 9884_CR63
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2017.1356556
– volume: 504
  start-page: 446
  year: 2013
  ident: 9884_CR30
  publication-title: Nature
  doi: 10.1038/nature12721
– volume: 7
  start-page: e34242
  year: 2012
  ident: 9884_CR47
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0034242
– volume: 3
  start-page: 686
  year: 2020
  ident: 9884_CR49
  publication-title: Commun Biol
  doi: 10.1038/s42003-020-01416-z
– volume: 334
  start-page: 255
  year: 2011
  ident: 9884_CR108
  publication-title: Science
  doi: 10.1126/science.1209791
– volume: 17
  start-page: 189
  year: 2016
  ident: 9884_CR3
  publication-title: Genome Biol
  doi: 10.1186/s13059-016-1052-7
– volume: 6
  start-page: 6440
  year: 2015
  ident: 9884_CR113
  publication-title: Nat Commun
  doi: 10.1038/ncomms7440
– volume: 6
  start-page: 2033
  year: 2012
  ident: 9884_CR10
  publication-title: ISME J
  doi: 10.1038/ismej.2012.54
– volume: 108
  start-page: 3047
  year: 2011
  ident: 9884_CR22
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1010529108
– volume: 167
  start-page: 1469
  year: 2016
  ident: 9884_CR92
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.018
– volume: 2
  start-page: 16221
  year: 2016
  ident: 9884_CR98
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2016.221
– volume: 11
  start-page: 978
  year: 2020
  ident: 9884_CR27
  publication-title: Front Neurol
  doi: 10.3389/fneur.2020.00978
– year: 2020
  ident: 9884_CR117
  publication-title: Open Forum Infect Dis
  doi: 10.1093/ofid/ofaa114
– volume: 180
  start-page: 221
  year: 2020
  ident: 9884_CR112
  publication-title: Cell
  doi: 10.1016/j.cell.2019.12.025
– volume: 137
  start-page: e1711
  issue: 1716–1724
  year: 2009
  ident: 9884_CR41
  publication-title: Gastroenterology
SSID ssj0017617
Score 2.557715
SecondaryResourceType review_article
Snippet The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 263
SubjectTerms Abundance
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Digestive system
Disease
disease control
Gastrointestinal Microbiome - genetics
Gene expression
Genetic control
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - microbiology
Genetic diversity
Genetic engineering
Genetic Predisposition to Disease
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genotype & phenotype
Gut microbiota
Heritability
Host-Pathogen Interactions - genetics
Human Genetics
Humans
Intestinal microflora
intestinal microorganisms
Life Sciences
Mice
Mice, Knockout
microbiome
Microbiomes
Microbiota
phenotype
Phenotypes
RNA, Ribosomal, 16S - genetics
Twin studies
SummonAdditionalLinks – databaseName: SpringerLink Contemporary (1997 - Present)
  dbid: RSV
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3ZSsQwMMiq4Iv3sbpKBd-00E3SNHkUcfFBFvFi8aU0ly5oK27X73eSbSvrsaDPmbbJHJmZzoXQEaFayEixUBHJQyqJDSUWPLQRNZnQnFvlp5ZcJv0-HwzEVVUUNqqz3euQpL-pm2I3N3bMVROD-ys4pyFcvPOg7rgb2HB9c9_EDsAx90XSAkQZvImoKpX5-R3T6uibjfk9VfJLvNSrod7K_w6wipYrszM4nfDJGpoz-TpafCj8T_UNhC-KURkAL7mSxqBKXw8KGzyOy-BlOGnW9GICl4BeZXltorve-e3ZRVhNUwgV2HxlGEtmTBQpRxRBLHhGSkaZiJiiBGtsGLOWZSTRXcVl1xqglhZaW01UFktCyBZq5UVudlAQqxi8Ok1MkoFFSLTkzKjIGClJrDS1bdStkZqqqtW4m3jxnDZNkj0uUsBF6nGR4jY6bp55nTTamAndqWmVVkI3SsE7IuAPJt24jQ6bZRAXFwPJclOMHQwFBxiDnTwDhhEGeoAI2kbbE_I3WwKlHwuKYQPJFGM0AK5d9_RKPnzybbs5FsCu8N2Tmj0-t_77SXf_Br6HlrDnMJei2EGt8m1s9tGCei-Ho7cDLygf0FgNrA
  priority: 102
  providerName: Springer Nature
Title Host genetic control of gut microbiome composition
URI https://link.springer.com/article/10.1007/s00335-021-09884-2
https://www.ncbi.nlm.nih.gov/pubmed/34159422
https://www.proquest.com/docview/2553619715
https://www.proquest.com/docview/2544462080
https://www.proquest.com/docview/2636538394
https://pubmed.ncbi.nlm.nih.gov/PMC8295090
Volume 32
WOSCitedRecordID wos000664433600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1432-1777
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0017617
  issn: 0938-8990
  databaseCode: M7P
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1432-1777
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0017617
  issn: 0938-8990
  databaseCode: 7X7
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1432-1777
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0017617
  issn: 0938-8990
  databaseCode: BENPR
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: Springer Journals
  customDbUrl:
  eissn: 1432-1777
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017617
  issn: 0938-8990
  databaseCode: RSV
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbxMxEB7RFiQuvFtSSrRI3MBiY3u99qkC1KoHFEXloYjLav1qI7W7pdnw-xk7zlahai69-GKv1vbM2N94XgDvGbdK50YQw7QkXDNPNFWS-Jy7WlkpvYlVS76V47GcTtUkPbjNk1vl6kyMB7VtTXgj_4TQlyHYL0fF4dUfEqpGBetqKqGxBTshSwKNrnuT3oqAKnoMl1Yo1KhX5CloJobOhSJmITYZlWklJSd0_WK6hTZvO03-ZzmNF9Lx0_su5Rk8SVA0-7zknefwwDUv4NHvNj60vwR60s67DPkrhDlmyaU9a312tuiyy9kygdOly4JTevL8egU_j49-fD0hqcICMYgDO1Jo4Vyem0AoxTxqS0bntcqF4Yxa6oTwXtSstCMj9cg7pKBV1nrLTF1oxtgubDdt415DVpgCNT3LXFkjSmRWS-FM7pzWrDCW-wGMVttbmZR-PFTBuKj6xMmRJBWSpIokqegAPvTfXC2Tb2wcfbDa7ioJ4ry62esBvOu7UYSCXaRuXLsIYzgqxRSx84Yxggm8G5jiA9hbMkI_JQQCheIUJ1CusUg_IKTwXu9pZucxlbekChEb_vfjiplupn73Svc3r_QNPKaRsYOb4gFsd9cL9xYemr_dbH49hK1yWsZWDmHny9F4cjqMYoPt6fdf_wCDyxw5
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VLQgu5Q0LBYIEJ4ia2I5jHxBCQLVVlxWHIq24hPgFK9GkdLMg_lR_Y8fOo1oq9tYD50yUcebh-ex5ADynzEiVaB5rqkTMFHWxIlLELmG2lEYIp8PUkkk-nYrZTH7agNO-FsanVfY-MThqU2t_Rr6LoS_FYD9PszfHP2M_NcrfrvYjNFq1OLB_fiNkW7zef4_yfUHI3ofDd-O4myoQa4x9mjhT3Nok0Z45SR0iBK2SUiZcM0oMsZw7x0uam1QLlTqLXBtpjDNUl5mi_gAUXf4W-vHcg718NgC8NOdhwm8i0Ykgjkm6Ip1QqueHpvlaaATvUggWk9WN8EJ0ezFJ86-b2rAB7t34337dTdjuQu3obWsbt2DDVrfh6pc6XCTcATKuF02E9uPLOKMuZT-qXfRt2URH87ZB1ZGNfNJ9l9l2Fz5fCsP3YLOqK_sAokxniGQNtXmJUTA1SnCrE2uVopk2zI0g7cVZ6K69up_y8aMYGkMHFShQBYqgAgUZwcvhneO2ucha6p1evEXnaBbFuWxH8Gx4jC7C3_uUla2XnoYh6CeIDdbQcMpx76OSjeB-q3gDSxjoZJIRZCBfUcmBwLcoX31Szb-HVuWCSIxI8buveuU9Z_3fK324fqVP4dr48OOkmOxPDx7BdRKMyqdk7sBmc7K0j-GK_tXMFydPgnlG8PWylfoMODJ3gg
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VW0BceFOWFggSnCBq1nYc-4AQ0K5atVqtEEgVlxC_yko0Kd0siL_WX8fYeVRLxd564BxHGcefx994XgAvKDNSJZrHmioRM0VdrIgUsUuYLaQRwunQteQwm0zE0ZGcrsF5lwvjwyo7nRgUtam0vyPfRupLkexno3TbtWER053x29Mfse8g5T2tXTuNBiIH9vcvNN_mb_Z3cK1fEjLe_fRhL247DMQaeVAdp4pbmyTaCyqpQ2tBq6SQCdeMEkMs587xgmZmpIUaOYszMNIYZ6guUkX9ZSiq__UMSQYbwPr73cn0Y-_DyHjo95tIVClo1SRtyk5I3PMt1HxmNJryUggWk-Vj8RLXvRyy-ZffNhyH49v_84-8A7daEh69a3bNXViz5T24_qUKLob7QPaqeR3hzvIJnlEbzB9VLjpe1NHJrClddWIjH47fxrw9gM9XIvBDGJRVaR9BlOoUbVxDbVYgP6ZGCW51Yq1SNNWGuSGMuqXNdVt43ff_-J73JaMDHHKEQx7gkJMhvOrfOW3KjqwcvdUtdd6qoHl-sc5DeN4_RuXhPUJFaauFH8MY4wSthhVjOOV4KlLJhrDRgLAXCSlQKhlBAbIlePYDfPHy5Sfl7FsoYi6IRK6K333dAflC9H_P9PHqmT6DG4jl_HB_crAJN0nYXz5WcwsG9dnCPoFr-mc9m589bfdqBF-vGtV_AFWOgaI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Host+genetic+control+of+gut+microbiome+composition&rft.jtitle=Mammalian+genome&rft.au=Bubier%2C+Jason+A&rft.au=Chesler%2C+Elissa+J&rft.au=Weinstock%2C+George+M&rft.date=2021-08-01&rft.pub=Springer+Nature+B.V&rft.issn=0938-8990&rft.eissn=1432-1777&rft.volume=32&rft.issue=4&rft.spage=263&rft.epage=281&rft_id=info:doi/10.1007%2Fs00335-021-09884-2&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0938-8990&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0938-8990&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0938-8990&client=summon