The impact of oxidative DNA damage and stress on telomere homeostasis

•Loss of telomere maintenance contributes ageing-related diseases and carcinogenesis.•Numerous diseases associated with oxidative stress are also associated with shortened telomeres.•Studies in human tissues, mouse models and cell culture provide evidence that oxidative stress accelerates telomere s...

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Vydané v:Mechanisms of ageing and development Ročník 177; s. 37 - 45
Hlavní autori: Barnes, Ryan P., Fouquerel, Elise, Opresko, Patricia L.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Ireland Elsevier B.V 01.01.2019
Predmet:
Aging - metabolism
Aging - pathology
Animals
Base excision repair
DNA Damage
Environmental Exposure - adverse effects
Humans
Mice
Oxidation-Reduction
Oxidative DNA damage
Oxidative Stress
Telomeres
Telomeres
Oxidative stress
Base excision repair
Oxidative DNA damage
ISSN:0047-6374, 1872-6216, 1872-6216
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Shrnutí:•Loss of telomere maintenance contributes ageing-related diseases and carcinogenesis.•Numerous diseases associated with oxidative stress are also associated with shortened telomeres.•Studies in human tissues, mouse models and cell culture provide evidence that oxidative stress accelerates telomere shortening.•Telomeres are highly sensitive to oxidative DNA damage, which can induce telomere losses and dysfunction.•Base excision repair of oxidative damage is essential for telomere maintenance. Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understanding of the mechanisms of telomere loss and preservation is important for human health. Numerous studies have shown that oxidative stress is associated with accelerated telomere shortening and dysfunction. Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer. Here we review the studies demonstrating associations between oxidative stress and accelerated telomere attrition in human tissue, mice and cell culture, and discuss possible mechanisms and cellular pathways that protect telomeres from oxidative damage.
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SourceType-Scholarly Journals-1
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ISSN:0047-6374
1872-6216
1872-6216
DOI:10.1016/j.mad.2018.03.013