The impact of oxidative DNA damage and stress on telomere homeostasis

•Loss of telomere maintenance contributes ageing-related diseases and carcinogenesis.•Numerous diseases associated with oxidative stress are also associated with shortened telomeres.•Studies in human tissues, mouse models and cell culture provide evidence that oxidative stress accelerates telomere s...

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Vydáno v:	Mechanisms of ageing and development Ročník 177; s. 37 - 45
Hlavní autoři:	Barnes, Ryan P., Fouquerel, Elise, Opresko, Patricia L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Ireland Elsevier B.V 01.01.2019
Témata:	Aging - metabolism Aging - pathology Animals Base excision repair DNA Damage Environmental Exposure - adverse effects Humans Mice Oxidation-Reduction Oxidative DNA damage Oxidative Stress Telomeres Telomeres Oxidative stress Base excision repair Oxidative DNA damage
ISSN:	0047-6374, 1872-6216, 1872-6216
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	•Loss of telomere maintenance contributes ageing-related diseases and carcinogenesis.•Numerous diseases associated with oxidative stress are also associated with shortened telomeres.•Studies in human tissues, mouse models and cell culture provide evidence that oxidative stress accelerates telomere shortening.•Telomeres are highly sensitive to oxidative DNA damage, which can induce telomere losses and dysfunction.•Base excision repair of oxidative damage is essential for telomere maintenance. Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understanding of the mechanisms of telomere loss and preservation is important for human health. Numerous studies have shown that oxidative stress is associated with accelerated telomere shortening and dysfunction. Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer. Here we review the studies demonstrating associations between oxidative stress and accelerated telomere attrition in human tissue, mice and cell culture, and discuss possible mechanisms and cellular pathways that protect telomeres from oxidative damage.
AbstractList	Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understanding of the mechanisms of telomere loss and preservation is important for human health. Numerous studies have shown that oxidative stress is associated with accelerated telomere shortening and dysfunction. Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer. Here we review the studies demonstrating associations between oxidative stress and accelerated telomere attrition in human tissue, mice and cell culture, and discuss possible mechanisms and cellular pathways that protect telomeres from oxidative damage. •Loss of telomere maintenance contributes ageing-related diseases and carcinogenesis.•Numerous diseases associated with oxidative stress are also associated with shortened telomeres.•Studies in human tissues, mouse models and cell culture provide evidence that oxidative stress accelerates telomere shortening.•Telomeres are highly sensitive to oxidative DNA damage, which can induce telomere losses and dysfunction.•Base excision repair of oxidative damage is essential for telomere maintenance. Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understanding of the mechanisms of telomere loss and preservation is important for human health. Numerous studies have shown that oxidative stress is associated with accelerated telomere shortening and dysfunction. Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer. Here we review the studies demonstrating associations between oxidative stress and accelerated telomere attrition in human tissue, mice and cell culture, and discuss possible mechanisms and cellular pathways that protect telomeres from oxidative damage. Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understanding of the mechanisms of telomere loss and preservation is important for human health. Numerous studies have shown that oxidative stress is associated with accelerated telomere shortening and dysfunction. Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer. Here we review the studies demonstrating associations between oxidative stress and accelerated telomere attrition in human tissue, mice and cell culture, and discuss possible mechanisms and cellular pathways that protect telomeres from oxidative damage.Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understanding of the mechanisms of telomere loss and preservation is important for human health. Numerous studies have shown that oxidative stress is associated with accelerated telomere shortening and dysfunction. Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer. Here we review the studies demonstrating associations between oxidative stress and accelerated telomere attrition in human tissue, mice and cell culture, and discuss possible mechanisms and cellular pathways that protect telomeres from oxidative damage.
Author	Barnes, Ryan P. Opresko, Patricia L. Fouquerel, Elise
Author_xml	– sequence: 1 givenname: Ryan P. surname: Barnes fullname: Barnes, Ryan P. – sequence: 2 givenname: Elise surname: Fouquerel fullname: Fouquerel, Elise – sequence: 3 givenname: Patricia L. surname: Opresko fullname: Opresko, Patricia L. email: plo4@pitt.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29604323$$D View this record in MEDLINE/PubMed
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Snippet	•Loss of telomere maintenance contributes ageing-related diseases and carcinogenesis.•Numerous diseases associated with oxidative stress are also associated... Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication,...
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SubjectTerms	Aging - metabolism Aging - pathology Animals Base excision repair DNA Damage Environmental Exposure - adverse effects Humans Mice Oxidation-Reduction Oxidative DNA damage Oxidative Stress Telomeres
Title	The impact of oxidative DNA damage and stress on telomere homeostasis
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