The Biogenesis, Functions, and Challenges of Circular RNAs

Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low levels and often exhibit cell-type-specific and tissue-specific patterns. Recent studies have shown that their biogenesis requ...

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Bibliographic Details
Published in:	Molecular cell Vol. 71; no. 3; p. 428
Main Authors:	Li, Xiang, Yang, Li, Chen, Ling-Ling
Format:	Journal Article
Language:	English
Published:	United States 02.08.2018
Subjects:	Alternative Splicing Animals Exons Humans MicroRNAs - genetics RNA - genetics RNA - metabolism RNA - physiology RNA Precursors - metabolism RNA Splicing RNA, Messenger - metabolism Spliceosomes - metabolism intronic complementary sequences spliceosomal machinery RNA-seq circRNA circular RNA function back-splicing biogenesis linear RNA RNA binding proteins
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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