Increased Oxidative Phosphorylation Is Required for Stemness Maintenance in Liver Cancer Stem Cells from Hepatocellular Carcinoma Cell Line HCCLM3 Cells

Cancer stem cells (CSCs) are considered to be the main cause of tumor recurrence, metastasis, and an unfavorable prognosis. Energy metabolism is closely associated with cell stemness. However, how the stemness of liver cancer stem cells (LCSCs) is regulated by metabolic/oxidative stress remains poor...

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Bibliographic Details
Published in:	International Journal of Molecular Sciences Vol. 21; no. 15; p. 5276
Main Authors:	Liu, Ge, Luo, Qing, Li, Hong, Liu, Qiuping, Ju, Yang, Song, Guanbin
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25.07.2020 MDPI
Subjects:	Acids cancer stem cells Cancer therapies Carcinoma, Hepatocellular Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor cell metabolism Chemotherapy Dehydrogenases Energy Flow cytometry Glucose glycolysis hepatocellular carcinoma Humans Kinases Liver cancer Liver Neoplasms Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Metabolism Mitochondria Mitochondria, Liver Mitochondria, Liver - metabolism Mitochondria, Liver - pathology Mitochondrial DNA Neoplastic Stem Cells Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oxidative Phosphorylation Phosphorylation Quinazolinones Quinazolinones - pharmacology Stem cells Studies cell metabolism cancer stem cells hepatocellular carcinoma oxidative phosphorylation glycolysis
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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