Molecular detection of monkeypox and related viruses: challenges and opportunities

The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility ( R 0 ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox...

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Veröffentlicht in:	Virus genes Jg. 59; H. 3; S. 343 - 350
Hauptverfasser:	Ghate, Sudeep D., Suravajhala, Prashanth, Patil, Prakash, Vangala, Rajani Kanth, Shetty, Praveenkumar, Rao, R. Shyama Prasad
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.06.2023 Springer Nature B.V
Schlagworte:	Antibodies Antigens bioinformatics Biomedical and Life Sciences Biomedicine complement Coronaviruses COVID-19 vaccines disease control Disease management DNA, Viral - genetics Epidemics Fatalities Genomes Hemagglutinins Humans Immunization Infectious diseases Medical Microbiology Monkeypox virus Monkeypox virus - genetics Morbidity mortality Mpox Mpox (monkeypox) - diagnosis Mpox (monkeypox) - pathology Peptides Plant Sciences Polymerase Chain Reaction Proteins Proteomics Public Health Review Paper Reviews Scientific imaging Smallpox tumor necrosis factor receptors Tumor necrosis factor-TNF Virology Viruses World Health Organization Zoonoses Molecular evolution Diagnostics Epidemiology and public health Orthopoxvirus Viral genome surveillance Emerging infectious diseases
ISSN:	0920-8569, 1572-994X, 1572-994X
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Abstract	The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility ( R 0 ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed.
AbstractList	The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility ( R 0 ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed. The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility (R0 ≈ 0.58) and fatality rate (0-3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed.The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility (R0 ≈ 0.58) and fatality rate (0-3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed. The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility (R0 ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed. The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility (R₀ ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed. The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility (R ≈ 0.58) and fatality rate (0-3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed.
Author	Ghate, Sudeep D. Shetty, Praveenkumar Rao, R. Shyama Prasad Patil, Prakash Suravajhala, Prashanth Vangala, Rajani Kanth
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Cites_doi	10.1093/cid/cit703 10.4269/ajtmh.2010.09-0361 10.3201/eid2002.130118 10.1098/rstb.2011.0354 10.1002/jmv.21385 10.1016/S0166-0934(98)00099-8 10.7883/yoken.JJID.2008.140 10.1016/j.cell.2012.05.049 10.1016/j.virol.2005.05.030 10.1038/nm1261 10.1099/vir.0.81215-0 10.1016/j.jviromet.2008.07.018 10.1128/AAC.00021-09 10.1006/viro.2000.0603 10.1016/j.jviromet.2014.10.004 10.1016/S0014-5793(01)03144-1 10.1007/s11262-010-0560-x 10.1128/JCM.41.8.3835-3839.2003 10.3389/fpubh.2018.00241 10.3201/eid2304.161041 10.2217/17460913.2.1.17 10.15585/mmwr.mm6710a5 10.1056/NEJMoa032299 10.1128/JCM.40.6.1985-1988.2002 10.1016/j.jviromet.2011.05.002 10.1006/viro.2002.1446 10.4269/ajtmh.2005.73.428 10.1016/S0166-0934(96)02155-6 10.1016/B978-0-12-800964-2.00017-3 10.1038/labinvest.3700143 10.1016/j.jcv.2020.104455 10.1371/journal.pone.0006342 10.1128/jcm.33.8.2069-2076.1995 10.2353/jmoldx.2010.090035 10.1371/journal.pone.0141527 10.1002/jmv.21494 10.1016/S1473-3099(21)00048-7 10.1016/j.mcp.2005.05.003 10.1038/s41579-021-00639-z 10.1016/j.jcv.2006.03.012 10.1177/11769343211064616 10.1371/journal.pone.0096930 10.1016/j.diagmicrobio.2019.03.015 10.1038/s41598-021-81376-4 10.1016/j.jviromet.2010.07.012 10.1021/pr070432+
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References	N Chen (1975_CR15) 2005; 340 SN Shchelkunov (1975_CR41) 2001; 509 Y Li (1975_CR48) 2006; 36 JR Kugelman (1975_CR45) 2014; 20 N Putkuri (1975_CR33) 2009; 81 H Meyer (1975_CR35) 1997; 64 1975_CR19 SN Shchelkunov (1975_CR40) 2002; 297 1975_CR18 I Iizuka (1975_CR34) 2009; 81 M Saijo (1975_CR37) 2008; 61 S Parker (1975_CR51) 2007; 2 L Luciani (1975_CR11) 2021; 11 1975_CR10 D Coulson (1975_CR43) 2011; 42 M Aitichou (1975_CR28) 2005; 19 MJ Espy (1975_CR31) 2002; 40 JA Usme-Ciro (1975_CR22) 2017; 23 1975_CR50 RW Peeling (1975_CR20) 2021; 21 SD Davi (1975_CR38) 2019; 95 A Scohy (1975_CR21) 2020; 129 R Stadhouders (1975_CR47) 2010; 12 KN Durski (1975_CR6) 2018; 67 1975_CR3 C Dumont (1975_CR53) 2014; 9 MW Eshoo (1975_CR25) 2009; 4 RA Maksyutov (1975_CR55) 2015; 211 RJ Grant (1975_CR26) 2010; 82 J Doellinger (1975_CR24) 2015; 10 1975_CR49 AM Likos (1975_CR14) 2005; 86 1975_CR46 NC Elde (1975_CR44) 2012; 150 KD Reed (1975_CR5) 2004; 350 KL Karem (1975_CR4) 2005; 12 RSP Rao (1975_CR42) 2021; 17 H Neubauer (1975_CR36) 1998; 74 NP Manes (1975_CR23) 2008; 7 M Woolhouse (1975_CR1) 2012; 367 SL Ropp (1975_CR27) 1995; 33 CR Damaso (1975_CR30) 2000; 277 1975_CR39 J Huggins (1975_CR12) 2009; 53 Y Li (1975_CR16) 2010; 169 SM Ibrahim (1975_CR32) 2003; 41 DA Kulesh (1975_CR7) 2004; 84 LA Learned (1975_CR8) 2005; 73 Y Edghill-Smith (1975_CR13) 2005; 11 N Sklenovská (1975_CR9) 2018; 6 AM McCollum (1975_CR17) 2014; 58 M Aitichou (1975_CR29) 2008; 153 SN Shchelkunov (1975_CR54) 2011; 175 S-C Kuo (1975_CR52) 2013; 33 RE Baker (1975_CR2) 2022; 20
References_xml	– volume: 58 start-page: 260 year: 2014 ident: 1975_CR17 publication-title: Clin Infect Dis doi: 10.1093/cid/cit703 – volume: 82 start-page: 318 year: 2010 ident: 1975_CR26 publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2010.09-0361 – volume: 20 start-page: 232 year: 2014 ident: 1975_CR45 publication-title: Emerg Infect Dis doi: 10.3201/eid2002.130118 – volume: 367 start-page: 2864 year: 2012 ident: 1975_CR1 publication-title: Philos Trans R Soc B: Biol Sci doi: 10.1098/rstb.2011.0354 – volume: 81 start-page: 146 year: 2009 ident: 1975_CR33 publication-title: J Med Virol doi: 10.1002/jmv.21385 – ident: 1975_CR39 – volume: 74 start-page: 201 year: 1998 ident: 1975_CR36 publication-title: J Virol Methods doi: 10.1016/S0166-0934(98)00099-8 – volume: 61 start-page: 140 year: 2008 ident: 1975_CR37 publication-title: Jpn J Infect Dis doi: 10.7883/yoken.JJID.2008.140 – volume: 150 start-page: 831 year: 2012 ident: 1975_CR44 publication-title: Cell doi: 10.1016/j.cell.2012.05.049 – volume: 340 start-page: 46 year: 2005 ident: 1975_CR15 publication-title: Virology doi: 10.1016/j.virol.2005.05.030 – volume: 11 start-page: 740 year: 2005 ident: 1975_CR13 publication-title: Nat Med doi: 10.1038/nm1261 – ident: 1975_CR49 – ident: 1975_CR50 – volume: 86 start-page: 2661 year: 2005 ident: 1975_CR14 publication-title: J Gen Virol doi: 10.1099/vir.0.81215-0 – volume: 153 start-page: 190 year: 2008 ident: 1975_CR29 publication-title: J Virol Methods doi: 10.1016/j.jviromet.2008.07.018 – volume: 53 start-page: 2620 year: 2009 ident: 1975_CR12 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00021-09 – volume: 277 start-page: 439 year: 2000 ident: 1975_CR30 publication-title: Virology doi: 10.1006/viro.2000.0603 – volume: 211 start-page: 8 year: 2015 ident: 1975_CR55 publication-title: J Virol Methods doi: 10.1016/j.jviromet.2014.10.004 – volume: 12 start-page: 867 year: 2005 ident: 1975_CR4 publication-title: Clin Diagn Lab Immunol – volume: 509 start-page: 66 year: 2001 ident: 1975_CR41 publication-title: FEBS Lett doi: 10.1016/S0014-5793(01)03144-1 – volume: 42 start-page: 171 year: 2011 ident: 1975_CR43 publication-title: Virus Genes doi: 10.1007/s11262-010-0560-x – volume: 41 start-page: 3835 year: 2003 ident: 1975_CR32 publication-title: J Clin Microbiol doi: 10.1128/JCM.41.8.3835-3839.2003 – volume: 6 start-page: 241 year: 2018 ident: 1975_CR9 publication-title: Front Public Health doi: 10.3389/fpubh.2018.00241 – volume: 23 start-page: 649 year: 2017 ident: 1975_CR22 publication-title: Emerg Infect Dis doi: 10.3201/eid2304.161041 – volume: 2 start-page: 17 year: 2007 ident: 1975_CR51 publication-title: Future Microbiol doi: 10.2217/17460913.2.1.17 – volume: 67 start-page: 306 year: 2018 ident: 1975_CR6 publication-title: MMWR Morb Mortal Wkly Rep doi: 10.15585/mmwr.mm6710a5 – volume: 350 start-page: 342 year: 2004 ident: 1975_CR5 publication-title: N Engl J Med doi: 10.1056/NEJMoa032299 – volume: 40 start-page: 1985 year: 2002 ident: 1975_CR31 publication-title: J Clin Microbiol doi: 10.1128/JCM.40.6.1985-1988.2002 – volume: 175 start-page: 163 year: 2011 ident: 1975_CR54 publication-title: J Virol Methods doi: 10.1016/j.jviromet.2011.05.002 – volume: 297 start-page: 172 year: 2002 ident: 1975_CR40 publication-title: Virology doi: 10.1006/viro.2002.1446 – volume: 73 start-page: 428 year: 2005 ident: 1975_CR8 publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2005.73.428 – volume: 64 start-page: 217 year: 1997 ident: 1975_CR35 publication-title: J Virol Methods doi: 10.1016/S0166-0934(96)02155-6 – ident: 1975_CR46 doi: 10.1016/B978-0-12-800964-2.00017-3 – volume: 84 start-page: 1200 year: 2004 ident: 1975_CR7 publication-title: Lab Invest doi: 10.1038/labinvest.3700143 – ident: 1975_CR10 – volume: 129 year: 2020 ident: 1975_CR21 publication-title: J Clin Virol doi: 10.1016/j.jcv.2020.104455 – volume: 4 year: 2009 ident: 1975_CR25 publication-title: PLoS ONE doi: 10.1371/journal.pone.0006342 – volume: 33 start-page: 2069 year: 1995 ident: 1975_CR27 publication-title: J Clin Microbiol doi: 10.1128/jcm.33.8.2069-2076.1995 – volume: 12 start-page: 109 year: 2010 ident: 1975_CR47 publication-title: J Mol Diagn doi: 10.2353/jmoldx.2010.090035 – ident: 1975_CR18 – volume: 33 start-page: 293 year: 2013 ident: 1975_CR52 publication-title: J Med Sci – volume: 10 year: 2015 ident: 1975_CR24 publication-title: PLoS ONE doi: 10.1371/journal.pone.0141527 – volume: 81 start-page: 1102 year: 2009 ident: 1975_CR34 publication-title: J Med Virol doi: 10.1002/jmv.21494 – volume: 21 start-page: e290 year: 2021 ident: 1975_CR20 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(21)00048-7 – volume: 19 start-page: 323 year: 2005 ident: 1975_CR28 publication-title: Mol Cell Probes doi: 10.1016/j.mcp.2005.05.003 – volume: 20 start-page: 193 year: 2022 ident: 1975_CR2 publication-title: Nat Rev Microbiol doi: 10.1038/s41579-021-00639-z – volume: 36 start-page: 194 year: 2006 ident: 1975_CR48 publication-title: J Clin Virol doi: 10.1016/j.jcv.2006.03.012 – ident: 1975_CR19 – volume: 17 start-page: 1064616 year: 2021 ident: 1975_CR42 publication-title: Evol Bioinform doi: 10.1177/11769343211064616 – volume: 9 year: 2014 ident: 1975_CR53 publication-title: PLoS ONE doi: 10.1371/journal.pone.0096930 – volume: 95 start-page: 41 year: 2019 ident: 1975_CR38 publication-title: Diagn Microbiol Infect Dis doi: 10.1016/j.diagmicrobio.2019.03.015 – volume: 11 start-page: 1798 year: 2021 ident: 1975_CR11 publication-title: Sci Rep doi: 10.1038/s41598-021-81376-4 – volume: 169 start-page: 223 year: 2010 ident: 1975_CR16 publication-title: J Virol Methods doi: 10.1016/j.jviromet.2010.07.012 – ident: 1975_CR3 – volume: 7 start-page: 960 year: 2008 ident: 1975_CR23 publication-title: J Proteome Res doi: 10.1021/pr070432+
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SubjectTerms	Antibodies Antigens bioinformatics Biomedical and Life Sciences Biomedicine complement Coronaviruses COVID-19 vaccines disease control Disease management DNA, Viral - genetics Epidemics Fatalities Genomes Hemagglutinins Humans Immunization Infectious diseases Medical Microbiology Monkeypox virus Monkeypox virus - genetics Morbidity mortality Mpox Mpox (monkeypox) - diagnosis Mpox (monkeypox) - pathology Peptides Plant Sciences Polymerase Chain Reaction Proteins Proteomics Public Health Review Paper Reviews Scientific imaging Smallpox tumor necrosis factor receptors Tumor necrosis factor-TNF Virology Viruses World Health Organization Zoonoses
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Title	Molecular detection of monkeypox and related viruses: challenges and opportunities
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