Long-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: A cohort study

•This is a large cohort study consisting of 385,650 adults aged ≥18 years in Taiwan.•PM2.5 was associated with higher risk of gastrointestinal cancer mortality.•PM2.5 was associated with higher risk of liver and colorectal cancers mortality. Information on the association between long-term exposure...

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Vydáno v:	Environment international Ročník 138; s. 105640
Hlavní autoři:	Guo, Cui, Chan, Ta-Chien, Teng, Yung-Chu, Lin, Changqing, Bo, Yacong, Chang, Ly-yun, Lau, Alexis K.H., Tam, Tony, Wong, Martin C.S., Qian Lao, Xiang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 01.05.2020 Elsevier
Témata:	adults air pollution control chronic exposure cohort studies colorectal neoplasms confidence interval death Gastrointestinal cancer mortality gastrointestinal neoplasms Live cancer mortality liver liver neoplasms Long-term exposure mortality particulates PM2.5 air pollution regression analysis satellites stomach Taiwan Taiwan Long-term exposure Gastrointestinal cancer mortality PM2.5 air pollution Live cancer mortality Taiwan PM(2.5) air pollution
ISSN:	0160-4120, 1873-6750, 1873-6750
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Shrnutí:	•This is a large cohort study consisting of 385,650 adults aged ≥18 years in Taiwan.•PM2.5 was associated with higher risk of gastrointestinal cancer mortality.•PM2.5 was associated with higher risk of liver and colorectal cancers mortality. Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce. This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal cancer and its subtypes in adults in Taiwan. A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual’s address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers. We found that each 10 µg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03–1.16) and 1.13 (95%CI: 1.02–1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00–1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer. Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0160-4120 1873-6750 1873-6750
DOI:	10.1016/j.envint.2020.105640