Feasibility of the use of Lentinula edodes mycelium in terbinafine remediation

A detailed understanding of the fate of xenobiotics introduced into the environment and the mechanisms involved in their biotransformation, biodegradation, and biosorption is essential to improve the efficiency of remediation techniques. Mycoremediation is a form of bioremediation technique that has...

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Vydáno v:3 Biotech Ročník 10; číslo 4; s. 184
Hlavní autoři: Kryczyk-Poprawa, Agata, Piotrowska, Joanna, Żmudzki, Paweł, Opoka, Włodzimierz, Muszyńska, Bożena
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.04.2020
Springer Nature B.V
Témata:
Agriculture
Antifungal agents
Biodegradation
Bioinformatics
biomass
Biomaterials
Bioremediation
Biosorption
Biotechnology
Biotransformation
Cancer Research
Chemistry
Chemistry and Materials Science
Deamination
Demethylation
drug residues
Extracellular enzymes
Fungi
Fungicides
Hydroxylation
Lentinula edodes
naphthalenes
neutralization
Original
Original Article
Powder
Remediation
Rot
Stem Cells
Terbinafine
Toxins
Wastewater
white-rot fungi
Xenobiotics
Biodegradation
Edible mushrooms
Terbinafine
Lentinula edodes
ISSN:2190-572X, 2190-5738
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Shrnutí:A detailed understanding of the fate of xenobiotics introduced into the environment and the mechanisms involved in their biotransformation, biodegradation, and biosorption is essential to improve the efficiency of remediation techniques. Mycoremediation is a form of bioremediation technique that has become increasingly popular in recent years as fungi are known to produce various effective extracellular enzymes that have the potential to neutralize a wide variety of xenobiotics released into the environment. Hence, mycoremediation appears to be a promising technique for the removal of a wide array of toxins and pharmaceutical residues from a damaged environment and wastewater. This study primarily aimed to investigate whether white-rot fungus ( Lentinula edodes ) can be utilized for the bioremediation of common antifungal agent terbinafine, which is mainly available in the market as powder or cream. The cultures of L. edodes were cultivated in the medium containing terbinafine powder or terbinafine 1% cream, each at a final concentration of 0.1 mg mL −1 . The addition of terbinafine in powder form have a negative effect on biomass growth ( p  < 0.05). The total amount of terbinafine in the dry weight of mycelium after culture was estimated to be 7.63 ± 0.45 mg and 12.52 ± 2.46 mg for powder and cream samples, respectively. In addition, there were no traces of terbinafine in any of the samples of medium used for culturing L. edodes after the experimental duration period. The biodegradation products of terbinafine were identified for the first time using UPLC/MS/MS. The biodegradation of terbinafine resulted in the loss of 1-naphthylmethanol, which occurred via oxidative deamination, N -demethylation, or tert-butyl group hydroxylation. The results of the study demonstrate that L. edodes mycelium can be effectively used for the remediation of terbinafine.
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ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-020-02177-6