Dachshund binds p53 to block the growth of lung adenocarcinoma cells

Hyperactive EGF receptor (EGFR) and mutant p53 are common genetic abnormalities driving the progression of non-small cell lung cancer (NSCLC), the leading cause of cancer deaths in the world. The Drosophila gene Dachshund (Dac) was originally cloned as an inhibitor of hyperactive EGFR alleles. Given...

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Vydáno v:	Cancer research (Chicago, Ill.) Ročník 73; číslo 11; s. 3262
Hlavní autoři:	Chen, Ke, Wu, Kongming, Cai, Shaoxin, Zhang, Wei, Zhou, Jie, Wang, Jing, Ertel, Adam, Li, Zhiping, Rui, Hallgeir, Quong, Andrew, Lisanti, Michael P, Tozeren, Aydin, Tanes, Ceylan, Addya, Sankar, Gormley, Michael, Wang, Chenguang, McMahon, Steven B, Pestell, Richard G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.06.2013
Témata:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Animals Cell Cycle Checkpoints - physiology Cell Growth Processes - physiology Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - metabolism Eye Proteins - genetics Eye Proteins - metabolism Female Genes, p53 HCT116 Cells HEK293 Cells Heterografts Humans Immunohistochemistry Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Nude Rad51 Recombinase - antagonists & inhibitors Rad51 Recombinase - metabolism SOXB1 Transcription Factors - biosynthesis SOXB1 Transcription Factors - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transfection Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
ISSN:	1538-7445, 1538-7445
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