Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

Macrophages form a major cell population in the tumor microenvironment. They can be activated and polarized into tumor-associated macrophages (TAM) by the tumor-derived soluble molecules to promote tumor progression and metastasis. Here, we used comparative metabolomics coupled with biochemical and...

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Veröffentlicht in:	Molecular cell Jg. 77; H. 2; S. 213
Hauptverfasser:	Wu, Jing-Yiing, Huang, Tsai-Wang, Hsieh, Yi-Ting, Wang, Yi-Fu, Yen, Chia-Chien, Lee, Guan-Lin, Yeh, Chang-Ching, Peng, Yi-Jen, Kuo, Ya-Yi, Wen, Hsiu-Ting, Lin, Hui-Chen, Hsiao, Cheng-Wen, Wu, Kenneth K, Kung, Hsing-Jien, Hsu, Yu-Juei, Kuo, Cheng-Chin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.01.2020
Schlagworte:	A549 Cells Animals Cell Line, Tumor Cell Movement - physiology HT29 Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Lung Neoplasms - metabolism Lung Neoplasms - pathology Macrophages - metabolism Macrophages - pathology MCF-7 Cells Mice, Inbred C57BL Neoplasm Metastasis - pathology PC-3 Cells Receptors, G-Protein-Coupled - metabolism Signal Transduction - physiology Succinic Acid - metabolism Tumor Microenvironment - physiology succinate SUCNR1 metabolomics PI3K-HIF-1α axis tumor microenvironment cancer metastasis tumor-associated macrophages
ISSN:	1097-4164, 1097-4164
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