Toward a Shared Vision for Cancer Genomic Data

The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic, and clinical outcome data from National Cancer Institute–funded projects. A harmonization process will align sequencing data to the genome and identify mutations and alterations. For the past 2 years, the Nati...

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Vydáno v:The New England journal of medicine Ročník 375; číslo 12; s. 1109 - 1112
Hlavní autoři: Grossman, Robert L, Heath, Allison P, Ferretti, Vincent, Varmus, Harold E, Lowy, Douglas R, Kibbe, Warren A, Staudt, Louis M
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Massachusetts Medical Society 22.09.2016
Témata:
Application programming interface
Cancer therapies
Clinical trials
Datasets
Datasets as Topic
DNA, Neoplasm
Gene expression
Genome, Human
Genomes
Genomics
Humans
Information sharing
Medical research
Mutation
National Cancer Institute (U.S.)
Neoplasms - genetics
Precision Medicine
Researchers
Taxonomy
United States
ISSN:0028-4793, 1533-4406
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Popis
Shrnutí:The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic, and clinical outcome data from National Cancer Institute–funded projects. A harmonization process will align sequencing data to the genome and identify mutations and alterations. For the past 2 years, the National Cancer Institute (NCI), the University of Chicago, the Ontario Institute for Cancer Research, and Leidos Biomedical Research have been developing an information system called the NCI Genomic Data Commons (GDC) (see figure). The GDC will initially contain raw genomic data as well as diagnostic, histologic, and clinical outcome data from NCI-funded projects such as the Cancer Genome Atlas (TCGA) and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program. Unlike previous versions of these data sets, the genomic data will be “harmonized” using uniform analytic pipelines to align the raw sequencing data . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMp1607591