Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

Objective Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, of unknown etiology. Previous studies showed reverse transcriptase in serum of ALS patients at levels comparable to human immunodeficiency virus‐infected patients; however, the source and signifi...

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Bibliographic Details
Published in:	Annals of neurology Vol. 69; no. 1; pp. 141 - 151
Main Authors:	Douville, Renée, Liu, Jiankai, Rothstein, Jeffrey, Nath, Avindra
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2011 Wiley-Liss Wiley Subscription Services, Inc
Subjects:	Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - physiopathology Amyotrophic Lateral Sclerosis - virology Biological and medical sciences Brain - physiopathology Brain - virology Cerebral Cortex - physiopathology Cerebral Cortex - virology Cytogenetics Endogenous Retroviruses - genetics Endogenous Retroviruses - isolation & purification Female Gene Expression Gene Frequency - genetics HIV Human endogenous retrovirus Human immunodeficiency virus Humans Male Medical sciences Middle Aged Motor Neurons - virology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neurons Reverse Transcriptase Polymerase Chain Reaction - statistics & numerical data RNA, Messenger - genetics Transcriptional Activation - physiology Viral Proteins - genetics Human Nervous system diseases Neuron Central nervous system disease Amyotrophic lateral sclerosis Degenerative disease Spinal cord disease
ISSN:	0364-5134, 1531-8249, 1531-8249
Online Access:	Get full text
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