Typical and atypical pathology in primary progressive aphasia variants

Objective To characterize in vivo signatures of pathological diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by current diagnostic classification. Methods Extensive clinical, cognitive, neuroimaging, and neuropathological data were collected from 69 pa...

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Veröffentlicht in:	Annals of neurology Jg. 81; H. 3; S. 430 - 443
Hauptverfasser:	Spinelli, Edoardo G., Mandelli, Maria Luisa, Miller, Zachary A., Santos‐Santos, Miguel A, Wilson, Stephen M., Agosta, Federica, Grinberg, Lea T., Huang, Eric J., Trojanowski, John Q., Meyer, Marita, Henry, Maya L., Comi, Giancarlo, Rabinovici, Gil, Rosen, Howard J., Filippi, Massimo, Miller, Bruce L., Seeley, William W., Gorno‐Tempini, Maria Luisa
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.03.2017
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - classification Alzheimer Disease - pathology Alzheimer Disease - physiopathology Aphasia, Primary Progressive - classification Aphasia, Primary Progressive - pathology Aphasia, Primary Progressive - physiopathology Atrophy - pathology Female Frontotemporal Lobar Degeneration - classification Frontotemporal Lobar Degeneration - pathology Frontotemporal Lobar Degeneration - physiopathology Gray Matter - diagnostic imaging Humans Male Medical imaging Middle Aged Neuropathology Pathology Pick Disease of the Brain - pathology Pick Disease of the Brain - physiopathology Primary Progressive Nonfluent Aphasia - pathology Primary Progressive Nonfluent Aphasia - physiopathology Support Vector Machine tau Proteins - metabolism White Matter - diagnostic imaging
ISSN:	0364-5134, 1531-8249, 1531-8249
Online-Zugang:	Volltext
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