Localization of Angiogenic Growth Factors and Their Receptors in the Human Placental Bed Throughout Normal Human Pregnancy

During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms unde...

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Vydáno v:	Placenta (Eastbourne) Ročník 30; číslo 1; s. 79 - 87
Hlavní autoři:	Schiessl, B., Innes, B.A., Bulmer, J.N., Otun, H.A., Chadwick, T.J., Robson, S.C., Lash, G.E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier Ltd 01.01.2009 Elsevier
Témata:	Adult Angiopoietin Angiopoietins - metabolism Arteries - metabolism Biological and medical sciences Cesarean Section Early pregnancy Embryology: invertebrates and vertebrates. Teratology Extravillous trophoblast Female Fundamental and applied biological sciences. Psychology Gestational Age Humans Immunoenzyme Techniques Internal Medicine Neovascularization, Physiologic - physiology Obstetrics and Gynecology Placenta - anatomy & histology Placenta - blood supply Placental bed Placental Circulation - physiology Pregnancy Receptor, TIE-2 - metabolism Tie Trophoblasts - cytology Trophoblasts - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Young Adult Tie Early pregnancy Extravillous trophoblast Angiopoietin Vascular endothelial growth factor Placental bed Pregnancy Human Vertebrata Growth factor receptor Mammalia Placenta Angiogenic factor Fetal membrane Localization Normal
ISSN:	0143-4004, 1532-3102
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Abstract	During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms underlying ‘transformation’ of spiral arteries are not well understood. The aim of this study was to localize expression of members of the angiopoietin (Ang) family (Ang-1, Ang-2 and their receptor Tie-2) and the vascular endothelial growth factor (VEGF) family (VEGF-A, VEGF-C, VEGF-D and their receptors VEGF-R1, VEGF-R2 and VEGF-R3) in the placental bed throughout normal human pregnancy. Placental bed biopsies were obtained from women undergoing elective termination of pregnancy at 8–10, 12–14 and 16–20 weeks' gestation and elective caesarean section at term ( n = 6 each group). Paraffin-embedded sections were immunostained for Ang-1, Ang-2, Tie-2, VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2 and VEGF-R3 using an avidin biotin peroxidase technique. Reactivity of endovascular, interstitial, intramural and multinucleate extravillous trophoblast populations in the placental bed was analysed semi-quantitatively. There was an increase in the level of immunostaining of intramural EVT for Tie-2 and VEGF-C with increasing gestational age. In addition, there was a reduction in Ang-1 and Ang-2 expression by multinucleate interstitial EVT and of VEGF-R1 and VEGF-R2 by endovascular EVT with increasing gestational age. At the earlier gestational ages studied, immunostaining for Ang-1, Ang-2, Tie-2, VEGF-C, VEGF-R1 and VEGF-R2 on intramural EVT was reduced compared to both mononuclear interstitial and endovascular EVT. These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy.
AbstractList	Abstract During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms underlying ‘transformation’ of spiral arteries are not well understood. The aim of this study was to localize expression of members of the angiopoietin (Ang) family (Ang-1, Ang-2 and their receptor Tie-2) and the vascular endothelial growth factor (VEGF) family (VEGF-A, VEGF-C, VEGF-D and their receptors VEGF-R1, VEGF-R2 and VEGF-R3) in the placental bed throughout normal human pregnancy. Placental bed biopsies were obtained from women undergoing elective termination of pregnancy at 8–10, 12–14 and 16–20 weeks' gestation and elective caesarean section at term ( n = 6 each group). Paraffin-embedded sections were immunostained for Ang-1, Ang-2, Tie-2, VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2 and VEGF-R3 using an avidin biotin peroxidase technique. Reactivity of endovascular, interstitial, intramural and multinucleate extravillous trophoblast populations in the placental bed was analysed semi-quantitatively. There was an increase in the level of immunostaining of intramural EVT for Tie-2 and VEGF-C with increasing gestational age. In addition, there was a reduction in Ang-1 and Ang-2 expression by multinucleate interstitial EVT and of VEGF-R1 and VEGF-R2 by endovascular EVT with increasing gestational age. At the earlier gestational ages studied, immunostaining for Ang-1, Ang-2, Tie-2, VEGF-C, VEGF-R1 and VEGF-R2 on intramural EVT was reduced compared to both mononuclear interstitial and endovascular EVT. These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy. During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms underlying ‘transformation’ of spiral arteries are not well understood. The aim of this study was to localize expression of members of the angiopoietin (Ang) family (Ang-1, Ang-2 and their receptor Tie-2) and the vascular endothelial growth factor (VEGF) family (VEGF-A, VEGF-C, VEGF-D and their receptors VEGF-R1, VEGF-R2 and VEGF-R3) in the placental bed throughout normal human pregnancy. Placental bed biopsies were obtained from women undergoing elective termination of pregnancy at 8–10, 12–14 and 16–20 weeks' gestation and elective caesarean section at term ( n = 6 each group). Paraffin-embedded sections were immunostained for Ang-1, Ang-2, Tie-2, VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2 and VEGF-R3 using an avidin biotin peroxidase technique. Reactivity of endovascular, interstitial, intramural and multinucleate extravillous trophoblast populations in the placental bed was analysed semi-quantitatively. There was an increase in the level of immunostaining of intramural EVT for Tie-2 and VEGF-C with increasing gestational age. In addition, there was a reduction in Ang-1 and Ang-2 expression by multinucleate interstitial EVT and of VEGF-R1 and VEGF-R2 by endovascular EVT with increasing gestational age. At the earlier gestational ages studied, immunostaining for Ang-1, Ang-2, Tie-2, VEGF-C, VEGF-R1 and VEGF-R2 on intramural EVT was reduced compared to both mononuclear interstitial and endovascular EVT. These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy. During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms underlying 'transformation' of spiral arteries are not well understood. The aim of this study was to localize expression of members of the angiopoietin (Ang) family (Ang-1, Ang-2 and their receptor Tie-2) and the vascular endothelial growth factor (VEGF) family (VEGF-A, VEGF-C, VEGF-D and their receptors VEGF-R1, VEGF-R2 and VEGF-R3) in the placental bed throughout normal human pregnancy. Placental bed biopsies were obtained from women undergoing elective termination of pregnancy at 8-10, 12-14 and 16-20 weeks' gestation and elective caesarean section at term (n=6 each group). Paraffin-embedded sections were immunostained for Ang-1, Ang-2, Tie-2, VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2 and VEGF-R3 using an avidin biotin peroxidase technique. Reactivity of endovascular, interstitial, intramural and multinucleate extravillous trophoblast populations in the placental bed was analysed semi-quantitatively. There was an increase in the level of immunostaining of intramural EVT for Tie-2 and VEGF-C with increasing gestational age. In addition, there was a reduction in Ang-1 and Ang-2 expression by multinucleate interstitial EVT and of VEGF-R1 and VEGF-R2 by endovascular EVT with increasing gestational age. At the earlier gestational ages studied, immunostaining for Ang-1, Ang-2, Tie-2, VEGF-C, VEGF-R1 and VEGF-R2 on intramural EVT was reduced compared to both mononuclear interstitial and endovascular EVT. These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy.During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms underlying 'transformation' of spiral arteries are not well understood. The aim of this study was to localize expression of members of the angiopoietin (Ang) family (Ang-1, Ang-2 and their receptor Tie-2) and the vascular endothelial growth factor (VEGF) family (VEGF-A, VEGF-C, VEGF-D and their receptors VEGF-R1, VEGF-R2 and VEGF-R3) in the placental bed throughout normal human pregnancy. Placental bed biopsies were obtained from women undergoing elective termination of pregnancy at 8-10, 12-14 and 16-20 weeks' gestation and elective caesarean section at term (n=6 each group). Paraffin-embedded sections were immunostained for Ang-1, Ang-2, Tie-2, VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2 and VEGF-R3 using an avidin biotin peroxidase technique. Reactivity of endovascular, interstitial, intramural and multinucleate extravillous trophoblast populations in the placental bed was analysed semi-quantitatively. There was an increase in the level of immunostaining of intramural EVT for Tie-2 and VEGF-C with increasing gestational age. In addition, there was a reduction in Ang-1 and Ang-2 expression by multinucleate interstitial EVT and of VEGF-R1 and VEGF-R2 by endovascular EVT with increasing gestational age. At the earlier gestational ages studied, immunostaining for Ang-1, Ang-2, Tie-2, VEGF-C, VEGF-R1 and VEGF-R2 on intramural EVT was reduced compared to both mononuclear interstitial and endovascular EVT. These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy. During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its importance for successful pregnancy, the mechanisms underlying 'transformation' of spiral arteries are not well understood. The aim of this study was to localize expression of members of the angiopoietin (Ang) family (Ang-1, Ang-2 and their receptor Tie-2) and the vascular endothelial growth factor (VEGF) family (VEGF-A, VEGF-C, VEGF-D and their receptors VEGF-R1, VEGF-R2 and VEGF-R3) in the placental bed throughout normal human pregnancy. Placental bed biopsies were obtained from women undergoing elective termination of pregnancy at 8-10, 12-14 and 16-20 weeks' gestation and elective caesarean section at term (n=6 each group). Paraffin-embedded sections were immunostained for Ang-1, Ang-2, Tie-2, VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2 and VEGF-R3 using an avidin biotin peroxidase technique. Reactivity of endovascular, interstitial, intramural and multinucleate extravillous trophoblast populations in the placental bed was analysed semi-quantitatively. There was an increase in the level of immunostaining of intramural EVT for Tie-2 and VEGF-C with increasing gestational age. In addition, there was a reduction in Ang-1 and Ang-2 expression by multinucleate interstitial EVT and of VEGF-R1 and VEGF-R2 by endovascular EVT with increasing gestational age. At the earlier gestational ages studied, immunostaining for Ang-1, Ang-2, Tie-2, VEGF-C, VEGF-R1 and VEGF-R2 on intramural EVT was reduced compared to both mononuclear interstitial and endovascular EVT. These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy.
Author	Schiessl, B. Bulmer, J.N. Innes, B.A. Otun, H.A. Lash, G.E. Chadwick, T.J. Robson, S.C.
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Cites_doi	10.1067/mob.2002.126866 10.1095/biolreprod67.2.681 10.1089/lrb.2006.4.11 10.1053/plac.1999.0427 10.1016/S0002-9440(10)65089-4 10.1002/path.1700930218 10.1053/plac.2002.0850 10.1096/fj.06-6616com 10.1016/S0002-9440(10)64127-2 10.1016/j.cardiores.2004.12.002 10.1038/sj.bjp.0702757 10.1189/jlb.0406250 10.1016/S0143-4004(80)80012-9 10.1016/j.fertnstert.2006.11.102 10.1067/mob.2002.127720 10.1016/S0002-9440(10)65363-1 10.1016/S0002-9440(10)62567-9 10.1159/000063690 10.1007/BF03401869 10.1093/molehr/6.1.81 10.1095/biolreprod.105.040337 10.1016/j.placenta.2003.10.004 10.1161/01.RES.0000118600.91698.BB 10.1016/j.placenta.2005.12.006 10.1126/science.277.5322.55 10.1016/S0014-4827(02)00044-7 10.1067/S0002-9378(03)00838-X 10.1093/humrep/dem037 10.1136/jcp.48.9.876 10.1210/jc.2002-020195 10.1074/jbc.273.29.18514 10.1016/j.placenta.2003.08.020 10.1016/S0143-4004(81)80027-6
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Keywords	Tie Early pregnancy Extravillous trophoblast Angiopoietin Vascular endothelial growth factor Placental bed Pregnancy Human Vertebrata Growth factor receptor Mammalia Placenta Angiogenic factor Fetal membrane Localization Normal
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References	Robson, Simpson, Ball, Lyall, Bulmer (bib23) 2002; 187 Detre, Saclani, Dowsett (bib25) 1995; 48 Gu, Alexander, Gu, Zhang, Lewis, Wang (bib30) 2006; 4 Pijnenborg, Vercruysse, Hanssens (bib4) 2006; 27 Maisonpierre, Suri, Jones, Bartunkova, Wiegand, Radziejewski (bib14) 1997; 277 Plaisier, Rodrigues, Willems, Koolwijk, van Hinsbergh, Helmerhorst (bib21) 2007; 88 Fitzpatrick, Lash, Yanaihara, Charnock-Jones, Macdonald-Goodfellow, Graham (bib20) 2003; 283 Pongcharoen, Searle, Bulmer (bib24) 2004; 25 Distler, Hirth, Kurowska-Stolarska, Gay, Gay, Distler (bib34) 2003; 47 Zhou, McMaster, Woo, Janatpour, Perry, Karpanen (bib22) 2002; 160 Tammela, Enholm, Alitalo, Paavonen (bib17) 2005; 65 Lash, Cartwright, Whitley, Trew, Baker (bib19) 1999; 20 Lash, Otun, Innes, Bulmer, Searle, Robson (bib31) 2005; 73 Cartwright, Holden, Whitley (bib32) 1999; 128 Lash, Schiessl, Kirkley, Innes, Cooper, Searle (bib12) 2006; 80 Donoghue, Lederman, Susil, Rogers (bib29) 2007 Geva, Ginzinger, Zaloudek, Moore, Byrne, Jaffe (bib28) 2002; 87 Lyall, Bulmer, Kelly, Duffie, Robson (bib8) 1999; 154 Xu, Guimond, Chakraborty, Lala (bib11) 2002; 67 Charnock-Jones, Kaufmann, Mayhew (bib18) 2004; 25 Bischof, Meisser, Campana (bib10) 2000; 55 Kim, Chaiworapongsa, Gomez, Bujold, Yoon, Rotmensch, Thaler (bib7) 2002; 187 Goldman-Wohl, Ariel, Greenfield, Lavy, Yagel (bib27) 2000; 6 Kim, Bujold, Chaiworapongsa, Gomez, Yoon, Thaler, Rotmensch (bib6) 2003; 189 Lyall (bib2) 2002; 23 Lash, Otun, Innes, Kirkley, De Oliveira, Searle (bib33) 2006; 20 Brosens, Robertson, Dixon (bib9) 1967; 93 Leach, Babawale, Anderson, Lammiman (bib16) 2002; 39 Lyall, Bulmer, Duffie, Cousins, Theriault, Robson (bib3) 2001; 158 Witzenbichler, Maisonpierre, Jones, Yancopoulos, Isner (bib15) 1998; 273 Pijnenborg, Dixon, Robertson, Brosens (bib1) 1980; 1 Zhang, Smith, Baker, Charnock-Jones (bib13) 2001; 7 Dunk, Shams, Nijjar, Rhaman, Qiu, Bussolati (bib26) 2000; 156 Cao, Eriksson, Kubo, Alitalo, Cao, Thyberg (bib35) 2004; 94 Pijnenborg, Bland, Robertson, Dixon, Brosens (bib5) 1981; 2 Gu (10.1016/j.placenta.2008.10.004_bib30) 2006; 4 Pijnenborg (10.1016/j.placenta.2008.10.004_bib5) 1981; 2 Bischof (10.1016/j.placenta.2008.10.004_bib10) 2000; 55 Lyall (10.1016/j.placenta.2008.10.004_bib2) 2002; 23 Lash (10.1016/j.placenta.2008.10.004_bib19) 1999; 20 Charnock-Jones (10.1016/j.placenta.2008.10.004_bib18) 2004; 25 Kim (10.1016/j.placenta.2008.10.004_bib7) 2002; 187 Tammela (10.1016/j.placenta.2008.10.004_bib17) 2005; 65 Plaisier (10.1016/j.placenta.2008.10.004_bib21) 2007; 88 Pongcharoen (10.1016/j.placenta.2008.10.004_bib24) 2004; 25 Pijnenborg (10.1016/j.placenta.2008.10.004_bib4) 2006; 27 Detre (10.1016/j.placenta.2008.10.004_bib25) 1995; 48 Brosens (10.1016/j.placenta.2008.10.004_bib9) 1967; 93 Cao (10.1016/j.placenta.2008.10.004_bib35) 2004; 94 Kim (10.1016/j.placenta.2008.10.004_bib6) 2003; 189 Donoghue (10.1016/j.placenta.2008.10.004_bib29) 2007 Dunk (10.1016/j.placenta.2008.10.004_bib26) 2000; 156 Lyall (10.1016/j.placenta.2008.10.004_bib3) 2001; 158 Zhang (10.1016/j.placenta.2008.10.004_bib13) 2001; 7 Robson (10.1016/j.placenta.2008.10.004_bib23) 2002; 187 Lash (10.1016/j.placenta.2008.10.004_bib31) 2005; 73 Maisonpierre (10.1016/j.placenta.2008.10.004_bib14) 1997; 277 Leach (10.1016/j.placenta.2008.10.004_bib16) 2002; 39 Lash (10.1016/j.placenta.2008.10.004_bib33) 2006; 20 Zhou (10.1016/j.placenta.2008.10.004_bib22) 2002; 160 Distler (10.1016/j.placenta.2008.10.004_bib34) 2003; 47 Geva (10.1016/j.placenta.2008.10.004_bib28) 2002; 87 Lyall (10.1016/j.placenta.2008.10.004_bib8) 1999; 154 Goldman-Wohl (10.1016/j.placenta.2008.10.004_bib27) 2000; 6 Fitzpatrick (10.1016/j.placenta.2008.10.004_bib20) 2003; 283 Xu (10.1016/j.placenta.2008.10.004_bib11) 2002; 67 Lash (10.1016/j.placenta.2008.10.004_bib12) 2006; 80 Pijnenborg (10.1016/j.placenta.2008.10.004_bib1) 1980; 1 Cartwright (10.1016/j.placenta.2008.10.004_bib32) 1999; 128 Witzenbichler (10.1016/j.placenta.2008.10.004_bib15) 1998; 273
References_xml	– year: 2007 ident: bib29 article-title: Lymphangiogenesis of normal endometrium and endometrial adenocarcinoma publication-title: Human Reprod – volume: 187 start-page: 1137 year: 2002 end-page: 1142 ident: bib7 article-title: Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes publication-title: Am J Obstet Gynecol – volume: 47 start-page: 149 year: 2003 end-page: 161 ident: bib34 article-title: Angiogenic and angiostatic factors in the molecular control of angiogenesis publication-title: Q J Nucl Med – volume: 48 start-page: 876 year: 1995 end-page: 878 ident: bib25 article-title: A “quickscore” method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas publication-title: J Clin Pathol – volume: 94 start-page: 664 year: 2004 end-page: 670 ident: bib35 article-title: Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability publication-title: Circ Res – volume: 25 start-page: 103 year: 2004 end-page: 113 ident: bib18 article-title: Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation publication-title: Placenta – volume: 73 start-page: 374 year: 2005 end-page: 381 ident: bib31 article-title: Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases publication-title: Biol Reprod – volume: 20 start-page: 2512 year: 2006 end-page: 2518 ident: bib33 article-title: Interferon-γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels publication-title: FASEB J – volume: 7 start-page: 624 year: 2001 end-page: 635 ident: bib13 article-title: The regulation and localization of angiopoietin-1, -2, and their receptor Tie2 in normal and pathologic human placentae publication-title: Mol Med – volume: 25 start-page: 321 year: 2004 end-page: 330 ident: bib24 article-title: Placental Fas and Fas ligand expression in normal early, term and molar pregnancy publication-title: Placenta – volume: 2 start-page: 303 year: 1981 end-page: 316 ident: bib5 article-title: The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy publication-title: Placenta – volume: 20 start-page: 661 year: 1999 end-page: 667 ident: bib19 article-title: The effects of angiogenic growth factors on extravillous trophoblast invasion and motility publication-title: Placenta – volume: 1 start-page: 3 year: 1980 end-page: 19 ident: bib1 article-title: Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy publication-title: Placenta – volume: 93 start-page: 569 year: 1967 end-page: 579 ident: bib9 article-title: The physiological response of the vessels of the placental bed to normal pregnancy publication-title: J Pathol Bacteriol – volume: 158 start-page: 1713 year: 2001 end-page: 1721 ident: bib3 article-title: Human trophoblast invasion and spiral artery transformation: the role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction publication-title: Am J Pathol – volume: 80 start-page: 572 year: 2006 end-page: 580 ident: bib12 article-title: Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy publication-title: J Leuk Biol – volume: 55 start-page: 65 year: 2000 end-page: 71 ident: bib10 article-title: Mechanisms of endometrial control of trophoblast invasion publication-title: J Reprod Fertil Suppl – volume: 39 start-page: 246 year: 2002 end-page: 259 ident: bib16 article-title: Vasculogenesis, angiogenesis and the molecular organisation of endothelial junctions in the early human placenta publication-title: J Vasc Res – volume: 4 start-page: 11 year: 2006 end-page: 17 ident: bib30 article-title: Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta publication-title: Lymphat Res Biol – volume: 23 start-page: 555 year: 2002 end-page: 562 ident: bib2 article-title: The human placental bed revisited publication-title: Placenta – volume: 273 start-page: 18514 year: 1998 end-page: 18521 ident: bib15 article-title: Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2 publication-title: J Biol Chem – volume: 128 start-page: 181 year: 1999 end-page: 189 ident: bib32 article-title: Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide publication-title: Br J Pharmacol – volume: 277 start-page: 55 year: 1997 end-page: 60 ident: bib14 article-title: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis publication-title: Science – volume: 154 start-page: 1105 year: 1999 end-page: 1114 ident: bib8 article-title: Human trophoblast invasion and spiral artery transformation: the role of nitric oxide publication-title: Am J Pathol – volume: 65 start-page: 550 year: 2005 end-page: 563 ident: bib17 article-title: The biology of vascular endothelial growth factors publication-title: Cardiovasc Res. – volume: 88 start-page: 176 year: 2007 end-page: 187 ident: bib21 article-title: Different degrees of vascularisation and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues publication-title: Fertil Steril – volume: 87 start-page: 4213 year: 2002 end-page: 4224 ident: bib28 article-title: Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2 publication-title: J Clin Endocrinol Metab – volume: 27 start-page: 939 year: 2006 end-page: 958 ident: bib4 article-title: The uterine spiral arteries in human pregnancy: facts and controversies publication-title: Placenta – volume: 187 start-page: 1349 year: 2002 end-page: 1355 ident: bib23 article-title: Punch biopsy of the human placental bed publication-title: Am J Obstet Gynecol – volume: 67 start-page: 681 year: 2002 end-page: 689 ident: bib11 article-title: Control of proliferation, migration, and invasiveness of human extravillous trophoblast by decorin, a decidual product publication-title: Biol Reprod – volume: 189 start-page: 1063 year: 2003 end-page: 1069 ident: bib6 article-title: Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes publication-title: Am J Obstet Gynecol – volume: 283 start-page: 247 year: 2003 end-page: 255 ident: bib20 article-title: Inhibition of breast carcinoma and trophoblast cell invasiveness by vascular endothelial growth factor publication-title: Exp Cell Res. – volume: 156 start-page: 2185 year: 2000 end-page: 2199 ident: bib26 article-title: Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development publication-title: Am J Pathol – volume: 6 start-page: 81 year: 2000 end-page: 87 ident: bib27 article-title: Tie-2 and angiopoietin-2 expression at the fetal–maternal interface: a receptor ligand model for vascular remodelling publication-title: Mol Hum Reprod – volume: 160 start-page: 1405 year: 2002 end-page: 1423 ident: bib22 article-title: Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome publication-title: Am J Pathol – volume: 187 start-page: 1349 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib23 article-title: Punch biopsy of the human placental bed publication-title: Am J Obstet Gynecol doi: 10.1067/mob.2002.126866 – volume: 67 start-page: 681 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib11 article-title: Control of proliferation, migration, and invasiveness of human extravillous trophoblast by decorin, a decidual product publication-title: Biol Reprod doi: 10.1095/biolreprod67.2.681 – volume: 4 start-page: 11 year: 2006 ident: 10.1016/j.placenta.2008.10.004_bib30 article-title: Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta publication-title: Lymphat Res Biol doi: 10.1089/lrb.2006.4.11 – volume: 20 start-page: 661 year: 1999 ident: 10.1016/j.placenta.2008.10.004_bib19 article-title: The effects of angiogenic growth factors on extravillous trophoblast invasion and motility publication-title: Placenta doi: 10.1053/plac.1999.0427 – volume: 156 start-page: 2185 year: 2000 ident: 10.1016/j.placenta.2008.10.004_bib26 article-title: Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)65089-4 – volume: 93 start-page: 569 year: 1967 ident: 10.1016/j.placenta.2008.10.004_bib9 article-title: The physiological response of the vessels of the placental bed to normal pregnancy publication-title: J Pathol Bacteriol doi: 10.1002/path.1700930218 – volume: 23 start-page: 555 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib2 article-title: The human placental bed revisited publication-title: Placenta doi: 10.1053/plac.2002.0850 – volume: 20 start-page: 2512 year: 2006 ident: 10.1016/j.placenta.2008.10.004_bib33 article-title: Interferon-γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels publication-title: FASEB J doi: 10.1096/fj.06-6616com – volume: 158 start-page: 1713 year: 2001 ident: 10.1016/j.placenta.2008.10.004_bib3 article-title: Human trophoblast invasion and spiral artery transformation: the role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64127-2 – volume: 65 start-page: 550 year: 2005 ident: 10.1016/j.placenta.2008.10.004_bib17 article-title: The biology of vascular endothelial growth factors publication-title: Cardiovasc Res. doi: 10.1016/j.cardiores.2004.12.002 – volume: 128 start-page: 181 year: 1999 ident: 10.1016/j.placenta.2008.10.004_bib32 article-title: Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0702757 – volume: 80 start-page: 572 year: 2006 ident: 10.1016/j.placenta.2008.10.004_bib12 article-title: Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy publication-title: J Leuk Biol doi: 10.1189/jlb.0406250 – volume: 1 start-page: 3 year: 1980 ident: 10.1016/j.placenta.2008.10.004_bib1 article-title: Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy publication-title: Placenta doi: 10.1016/S0143-4004(80)80012-9 – volume: 88 start-page: 176 year: 2007 ident: 10.1016/j.placenta.2008.10.004_bib21 article-title: Different degrees of vascularisation and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2006.11.102 – volume: 187 start-page: 1137 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib7 article-title: Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes publication-title: Am J Obstet Gynecol doi: 10.1067/mob.2002.127720 – volume: 154 start-page: 1105 year: 1999 ident: 10.1016/j.placenta.2008.10.004_bib8 article-title: Human trophoblast invasion and spiral artery transformation: the role of nitric oxide publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)65363-1 – volume: 160 start-page: 1405 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib22 article-title: Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)62567-9 – volume: 39 start-page: 246 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib16 article-title: Vasculogenesis, angiogenesis and the molecular organisation of endothelial junctions in the early human placenta publication-title: J Vasc Res doi: 10.1159/000063690 – volume: 7 start-page: 624 year: 2001 ident: 10.1016/j.placenta.2008.10.004_bib13 article-title: The regulation and localization of angiopoietin-1, -2, and their receptor Tie2 in normal and pathologic human placentae publication-title: Mol Med doi: 10.1007/BF03401869 – volume: 6 start-page: 81 year: 2000 ident: 10.1016/j.placenta.2008.10.004_bib27 article-title: Tie-2 and angiopoietin-2 expression at the fetal–maternal interface: a receptor ligand model for vascular remodelling publication-title: Mol Hum Reprod doi: 10.1093/molehr/6.1.81 – volume: 73 start-page: 374 year: 2005 ident: 10.1016/j.placenta.2008.10.004_bib31 article-title: Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases publication-title: Biol Reprod doi: 10.1095/biolreprod.105.040337 – volume: 25 start-page: 103 year: 2004 ident: 10.1016/j.placenta.2008.10.004_bib18 article-title: Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation publication-title: Placenta doi: 10.1016/j.placenta.2003.10.004 – volume: 94 start-page: 664 year: 2004 ident: 10.1016/j.placenta.2008.10.004_bib35 article-title: Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability publication-title: Circ Res doi: 10.1161/01.RES.0000118600.91698.BB – volume: 27 start-page: 939 year: 2006 ident: 10.1016/j.placenta.2008.10.004_bib4 article-title: The uterine spiral arteries in human pregnancy: facts and controversies publication-title: Placenta doi: 10.1016/j.placenta.2005.12.006 – volume: 277 start-page: 55 year: 1997 ident: 10.1016/j.placenta.2008.10.004_bib14 article-title: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis publication-title: Science doi: 10.1126/science.277.5322.55 – volume: 283 start-page: 247 year: 2003 ident: 10.1016/j.placenta.2008.10.004_bib20 article-title: Inhibition of breast carcinoma and trophoblast cell invasiveness by vascular endothelial growth factor publication-title: Exp Cell Res. doi: 10.1016/S0014-4827(02)00044-7 – volume: 189 start-page: 1063 year: 2003 ident: 10.1016/j.placenta.2008.10.004_bib6 article-title: Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes publication-title: Am J Obstet Gynecol doi: 10.1067/S0002-9378(03)00838-X – volume: 55 start-page: 65 year: 2000 ident: 10.1016/j.placenta.2008.10.004_bib10 article-title: Mechanisms of endometrial control of trophoblast invasion publication-title: J Reprod Fertil Suppl – volume: 47 start-page: 149 year: 2003 ident: 10.1016/j.placenta.2008.10.004_bib34 article-title: Angiogenic and angiostatic factors in the molecular control of angiogenesis publication-title: Q J Nucl Med – year: 2007 ident: 10.1016/j.placenta.2008.10.004_bib29 article-title: Lymphangiogenesis of normal endometrium and endometrial adenocarcinoma publication-title: Human Reprod doi: 10.1093/humrep/dem037 – volume: 48 start-page: 876 year: 1995 ident: 10.1016/j.placenta.2008.10.004_bib25 article-title: A “quickscore” method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas publication-title: J Clin Pathol doi: 10.1136/jcp.48.9.876 – volume: 87 start-page: 4213 year: 2002 ident: 10.1016/j.placenta.2008.10.004_bib28 article-title: Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2002-020195 – volume: 273 start-page: 18514 year: 1998 ident: 10.1016/j.placenta.2008.10.004_bib15 article-title: Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2 publication-title: J Biol Chem doi: 10.1074/jbc.273.29.18514 – volume: 25 start-page: 321 year: 2004 ident: 10.1016/j.placenta.2008.10.004_bib24 article-title: Placental Fas and Fas ligand expression in normal early, term and molar pregnancy publication-title: Placenta doi: 10.1016/j.placenta.2003.08.020 – volume: 2 start-page: 303 year: 1981 ident: 10.1016/j.placenta.2008.10.004_bib5 article-title: The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy publication-title: Placenta doi: 10.1016/S0143-4004(81)80027-6
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Snippet	During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of... Abstract During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by...
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SubjectTerms	Adult Angiopoietin Angiopoietins - metabolism Arteries - metabolism Biological and medical sciences Cesarean Section Early pregnancy Embryology: invertebrates and vertebrates. Teratology Extravillous trophoblast Female Fundamental and applied biological sciences. Psychology Gestational Age Humans Immunoenzyme Techniques Internal Medicine Neovascularization, Physiologic - physiology Obstetrics and Gynecology Placenta - anatomy & histology Placenta - blood supply Placental bed Placental Circulation - physiology Pregnancy Receptor, TIE-2 - metabolism Tie Trophoblasts - cytology Trophoblasts - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Young Adult
Title	Localization of Angiogenic Growth Factors and Their Receptors in the Human Placental Bed Throughout Normal Human Pregnancy
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