Folic acid intake and folate status and colorectal cancer risk: A systematic review and meta-analysis

To evaluate the controversies among the studies assessing the association between folic acid intake or folate status and colorectal cancer risk. PubMed, Cochrane library and references of related articles were searched from January 2000 to September 2016. Studies on folic acid intake or folate statu...

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Vydáno v:Clinical nutrition (Edinburgh, Scotland) Ročník 37; číslo 6; s. 1926 - 1934
Hlavní autoři: Moazzen, Sara, Dolatkhah, Roya, Tabrizi, Jafar Sadegh, Shaarbafi, Jabraeel, Alizadeh, Behrooz Z., de Bock, Geertruida H., Dastgiri, Saeed
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.12.2018
Témata:
adenoma
bioavailability
case-control studies
cohort studies
Colorectal cancer
colorectal neoplasms
confidence interval
erythrocytes
Folate status
Folic acid
Meta-analysis
metabolism
odds ratio
randomized clinical trials
relative risk
Systematic review
vitamin status
RR
RBC
OR
Folate status
CRC
RCTs
Colorectal cancer
Systematic review
FA
Folic acid
Meta-analysis
ISSN:0261-5614, 1532-1983, 1532-1983
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Shrnutí:To evaluate the controversies among the studies assessing the association between folic acid intake or folate status and colorectal cancer risk. PubMed, Cochrane library and references of related articles were searched from January 2000 to September 2016. Studies on folic acid intake or folate status and colorectal cancer or adenoma risk were included. Full text review was conducted for potentially eligible studies. Quality assessment was performed. Random-effects meta-analysis was used to estimate risk ratio and 95% Confidence Intervals. Analysis was conducted by Comprehensive Meta-Analysis software. Folic acid supplement intake showed no significant effect on colorectal cancer risk in meta-analysis of randomized controlled trials, RR: 1.07 (95% CI: 0.86–1.43). The effect on risk was not significant in cohort studies either; RR = 0.96 (95% CI: 0.76–1.21). However, there was significant reduced colorectal cancer risk in total folate intake in cohort studies; 0.71 (95% CI: 0.59–0.86). Odds Ratio was also significantly reduced in case control studies; 0.77 (95% CI: 0.62–0.95). Nevertheless once folate status was measured as Red Blood Cell folate content, no significant effect on colorectal cancer risk was observed; 1.05 (95% CI: 0.85–1.30). The differences in bioavailability and metabolism of synthetic folic acid and natural dietary folate as well as variation in the baseline characteristics of subjects and various methods of folate status assessment might be the main reasons for these controversies. Findings of present study highlight the importance of individualized folic acid supplement intake given the fact that the beneficiary effects of long term folic acid supplementation is not confirmed.
Bibliografie:ObjectType-Article-1
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ISSN:0261-5614
1532-1983
1532-1983
DOI:10.1016/j.clnu.2017.10.010