Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also known as the mirror of the soul. The skin is involved in body temperature r...

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Published in:Pharmaceutics Vol. 16; no. 6; p. 817
Main Authors: Lunter, Dominique, Klang, Victoria, Eichner, Adina, Savic, Sanela M., Savic, Snezana, Lian, Guoping, Erdő, Franciska
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16.06.2024
MDPI
Subjects:
Clinical trials
drug (nano)formulation
Drug delivery systems
Drugs
Fibroblasts
Hair
Lipids
nanoparticulate delivery systems
Physiology
Review
Skin
skin penetration
skin structure and function
topical administration
transdermal delivery
Transdermal medication
nanoparticulate delivery systems
confocal Raman spectroscopy
drug (nano)formulation
topical administration
skin structure and function
Franz diffusion cell
skin penetration
skin-on-a-chip microfluidic devices
transdermal delivery
PBPK modeling of skin penetration
ISSN:1999-4923, 1999-4923
Online Access:Get full text
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Summary:Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also known as the mirror of the soul. The skin is involved in body temperature regulation by the storage of fat and water. It is an interesting tissue in regard to the local and transdermal application of active ingredients for prevention or treatment of pathological conditions. Topical and transdermal delivery is an emerging route of drug and cosmetic administration. It is beneficial for avoiding side effects and rapid metabolism. Many pharmaceutical, technological and cosmetic innovations have been described and patented recently in the field. In this review, the main features of skin morphology and physiology are presented and are being followed by the description of classical and novel nanoparticulate dermal and transdermal drug formulations. The biophysical aspects of the penetration of drugs and cosmetics into or across the dermal barrier and their investigation in diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems or with advanced analytical techniques are also shown. The current knowledge about mathematical modeling of skin penetration and the future perspectives are briefly discussed in the end, all also involving nanoparticulated systems.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16060817