CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway

Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1 in several cancer types has recently accumulated, its role in melanoma t...

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Vydáno v:	Cancer research (Chicago, Ill.) Ročník 70; číslo 19; s. 7489
Hlavní autoři:	Trimmer, Casey, Whitaker-Menezes, Diana, Bonuccelli, Gloria, Milliman, Janet N, Daumer, Kristin M, Aplin, Andrew E, Pestell, Richard G, Sotgia, Federica, Lisanti, Michael P, Capozza, Franco
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.10.2010
Témata:	Animals Caveolin 1 - biosynthesis Caveolin 1 - genetics Caveolin 1 - metabolism Cell Growth Processes - physiology Cell Line, Tumor Cell Membrane - metabolism Cell Movement - physiology Female Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Lung Neoplasms - secondary Melanocytes - metabolism Melanoma - genetics Melanoma - metabolism Melanoma - pathology Melanoma, Experimental - genetics Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Signal Transduction src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism
ISSN:	1538-7445, 1538-7445
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