The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas

Melanoma is a biologically heterogeneous disease composed of distinct clinicopathologic subtypes that frequently resist treatment. To explore the evolution of treatment resistance and metastasis, we used a combination of temporal and multilesional tumor sampling in conjunction with whole-exome seque...

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Veröffentlicht in:	Clinical cancer research Jg. 27; H. 5; S. 1516
Hauptverfasser:	Makohon-Moore, Alvin P, Lipson, Evan J, Hooper, Jody E, Zucker, Amanda, Hong, Jungeui, Bielski, Craig M, Hayashi, Akimasa, Tokheim, Collin, Baez, Priscilla, Kappagantula, Rajya, Kohutek, Zachary, Makarov, Vladimir, Riaz, Nadeem, Postow, Michael A, Chapman, Paul B, Karchin, Rachel, Socci, Nicholas D, Solit, David B, Chan, Timothy A, Taylor, Barry S, Topalian, Suzanne L, Iacobuzio-Donahue, Christine A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2021
Schlagworte:	Biomarkers, Tumor Drug Resistance, Neoplasm - genetics Evolution, Molecular Humans Immunotherapy - methods Melanoma - drug therapy Melanoma - genetics Melanoma - immunology Melanoma - pathology Mutation Prognosis Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - pathology Uveal Neoplasms - drug therapy Uveal Neoplasms - genetics Uveal Neoplasms - immunology Uveal Neoplasms - pathology
ISSN:	1557-3265, 1557-3265
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