The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas

Melanoma is a biologically heterogeneous disease composed of distinct clinicopathologic subtypes that frequently resist treatment. To explore the evolution of treatment resistance and metastasis, we used a combination of temporal and multilesional tumor sampling in conjunction with whole-exome seque...

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Vydáno v:	Clinical cancer research Ročník 27; číslo 5; s. 1516
Hlavní autoři:	Makohon-Moore, Alvin P, Lipson, Evan J, Hooper, Jody E, Zucker, Amanda, Hong, Jungeui, Bielski, Craig M, Hayashi, Akimasa, Tokheim, Collin, Baez, Priscilla, Kappagantula, Rajya, Kohutek, Zachary, Makarov, Vladimir, Riaz, Nadeem, Postow, Michael A, Chapman, Paul B, Karchin, Rachel, Socci, Nicholas D, Solit, David B, Chan, Timothy A, Taylor, Barry S, Topalian, Suzanne L, Iacobuzio-Donahue, Christine A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.03.2021
Témata:	Biomarkers, Tumor Drug Resistance, Neoplasm - genetics Evolution, Molecular Humans Immunotherapy - methods Melanoma - drug therapy Melanoma - genetics Melanoma - immunology Melanoma - pathology Mutation Prognosis Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - pathology Uveal Neoplasms - drug therapy Uveal Neoplasms - genetics Uveal Neoplasms - immunology Uveal Neoplasms - pathology
ISSN:	1557-3265, 1557-3265
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