Original antigenic sin: A comprehensive review

The concept of “original antigenic sin” was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed. Antigenic sin has been de...

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Bibliographic Details
Published in:	Journal of autoimmunity Vol. 83; pp. 12 - 21
Main Authors:	Vatti, Anup, Monsalve, Diana M., Pacheco, Yovana, Chang, Christopher, Anaya, Juan-Manuel, Gershwin, M. Eric
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.09.2017
Subjects:	Allergy and Immunology Animals Antibody-dependent enhancement Antigens - immunology Bocavirus Dengue Humans Immune Tolerance Immunity, Humoral Immunodominant Epitopes - immunology Immunologic Memory Infection - immunology Influenza Memory immune response Models, Immunological Vaccination Vaccines - immunology Zika virus Bocavirus Vaccination Dengue Influenza Zika virus Antibody-dependent enhancement Memory immune response
ISSN:	0896-8411, 1095-9157, 1095-9157
Online Access:	Get full text
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