Tissue distribution of quiescin Q6/sulfhydryl oxidase (QSOX) in developing mouse

Quiescin Q6/sulfhydryl oxidases (QSOX) are revisited thiol oxidases considered to be involved in the oxidative protein folding, cell cycle control and extracellular matrix remodeling. They contain thioredoxin domains and introduce disulfide bonds into proteins and peptides, with the concomitant hydr...

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Vydané v:Journal of molecular histology Ročník 39; číslo 2; s. 217 - 225
Hlavní autori: Portes, Kelly F., Ikegami, Cecília M., Getz, Joselito, Martins, Ana P., de Noronha, Lucia, Zischler, Luciana F., Klassen, Giseli, Camargo, Anamaria A., Zanata, Silvio M., Bevilacqua, Estela, Nakao, Lia S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Dordrecht Springer Netherlands 01.04.2008
Springer Nature B.V
Predmet:
Animals
Animals, Newborn
Antibody Specificity
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell cycle
Connective tissues
Developmental Biology
Disulfide bonds
Ectoderm
Endoderm
Extracellular matrix
Fetus - enzymology
Fetuses
Hydrogen peroxide
Immunohistochemistry
Life Sciences
Male
Mesoderm
Mice
Neonates
Original Paper
Oxidoreductases - analysis
Oxidoreductases - immunology
Oxidoreductases - metabolism
Protein folding
Rabbits
Rats
Rats, Wistar
Redox properties
Sulfhydryl oxidase
Thioredoxin
Tissue Distribution
Quiescin sulfhydryl oxidase
Mesoderm
Redox state
Mouse development
ISSN:1567-2379, 1567-2387
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Shrnutí:Quiescin Q6/sulfhydryl oxidases (QSOX) are revisited thiol oxidases considered to be involved in the oxidative protein folding, cell cycle control and extracellular matrix remodeling. They contain thioredoxin domains and introduce disulfide bonds into proteins and peptides, with the concomitant hydrogen peroxide formation, likely altering the redox environment. Since it is known that several developmental processes are regulated by the redox state, here we assessed if QSOX could have a role during mouse fetal development. For this purpose, an anti-recombinant mouse QSOX antibody was produced and characterized. In E 13.5 , E 16.5 fetal tissues, QSOX immunostaining was confined to mesoderm- and ectoderm-derived tissues, while in P1 neonatal tissues it was slightly extended to some endoderm-derived tissues. QSOX expression, particularly by epithelial tissues, seemed to be developmentally-regulated, increasing with tissue maturation. QSOX was observed in loose connective tissues in all stages analyzed, intra and possibly extracellularly, in agreement with its putative role in oxidative folding and extracellular matrix remodeling. In conclusion, QSOX is expressed in several tissues during mouse development, but preferentially in those derived from mesoderm and ectoderm, suggesting it could be of relevance during developmental processes.
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ISSN:1567-2379
1567-2387
DOI:10.1007/s10735-007-9156-8