The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism

The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides—a deleterious sphingolipid species—accumulate and cause lipotoxicity and metabolic disturbances. Dysregul...

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Vydané v:Nutrients Ročník 15; číslo 3; s. 703
Hlavní autori: Kim, Eunkyeong, Jeon, Sookyoung
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 30.01.2023
MDPI
Predmet:
Body fat
Care and treatment
Ceramides
Ceramides - metabolism
Complications and side effects
Development and progression
Diet
Disease
Fatty acids
Gastrointestinal surgery
Health aspects
Human subjects
Humans
Inflammation
Insulin resistance
Insulin Resistance - physiology
Lipids
lipotoxicity
Liver
Metabolic diseases
Metabolic Diseases - complications
Metabolic disorders
Metabolism
Obesity
Obesity - metabolism
Pathogenesis
Physiological aspects
Phytochemicals
Review
Risk factors
risk reduction
Sphingolipids - metabolism
Tumor necrosis factor-TNF
Weight control
South Korea
ceramide
metabolic disease
sphingolipid
obesity
phytochemical
ISSN:2072-6643, 2072-6643
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Abstract The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides—a deleterious sphingolipid species—accumulate and cause lipotoxicity and metabolic disturbances. Dysregulated ceramide metabolism appears to be a key feature in the pathogenesis of obesity-related metabolic diseases. Notably, dietary modification might have an impact on modulating ceramide metabolism. Phytochemicals are plant-derived compounds with various physiological properties, which have been shown to protect against obesity-related metabolic diseases. In this review, we aim to examine the impact of a myriad of phytochemicals and their dietary sources in altering ceramide deposition and ceramide-related metabolism from in vitro, in vivo, and human clinical/epidemiological studies. This review discusses how numerous phytochemicals are able to alleviate ceramide-induced metabolic defects and reduce the risk of obesity-related metabolic diseases via diverse mechanisms.
AbstractList The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides—a deleterious sphingolipid species—accumulate and cause lipotoxicity and metabolic disturbances. Dysregulated ceramide metabolism appears to be a key feature in the pathogenesis of obesity-related metabolic diseases. Notably, dietary modification might have an impact on modulating ceramide metabolism. Phytochemicals are plant-derived compounds with various physiological properties, which have been shown to protect against obesity-related metabolic diseases. In this review, we aim to examine the impact of a myriad of phytochemicals and their dietary sources in altering ceramide deposition and ceramide-related metabolism from in vitro, in vivo, and human clinical/epidemiological studies. This review discusses how numerous phytochemicals are able to alleviate ceramide-induced metabolic defects and reduce the risk of obesity-related metabolic diseases via diverse mechanisms.
The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides-a deleterious sphingolipid species-accumulate and cause lipotoxicity and metabolic disturbances. Dysregulated ceramide metabolism appears to be a key feature in the pathogenesis of obesity-related metabolic diseases. Notably, dietary modification might have an impact on modulating ceramide metabolism. Phytochemicals are plant-derived compounds with various physiological properties, which have been shown to protect against obesity-related metabolic diseases. In this review, we aim to examine the impact of a myriad of phytochemicals and their dietary sources in altering ceramide deposition and ceramide-related metabolism from in vitro, in vivo, and human clinical/epidemiological studies. This review discusses how numerous phytochemicals are able to alleviate ceramide-induced metabolic defects and reduce the risk of obesity-related metabolic diseases via diverse mechanisms.The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides-a deleterious sphingolipid species-accumulate and cause lipotoxicity and metabolic disturbances. Dysregulated ceramide metabolism appears to be a key feature in the pathogenesis of obesity-related metabolic diseases. Notably, dietary modification might have an impact on modulating ceramide metabolism. Phytochemicals are plant-derived compounds with various physiological properties, which have been shown to protect against obesity-related metabolic diseases. In this review, we aim to examine the impact of a myriad of phytochemicals and their dietary sources in altering ceramide deposition and ceramide-related metabolism from in vitro, in vivo, and human clinical/epidemiological studies. This review discusses how numerous phytochemicals are able to alleviate ceramide-induced metabolic defects and reduce the risk of obesity-related metabolic diseases via diverse mechanisms.
Audience Academic
Author Kim, Eunkyeong
Jeon, Sookyoung
AuthorAffiliation Department of Food Science and Nutrition and the Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Gangwon-do, Republic of Korea
AuthorAffiliation_xml – name: Department of Food Science and Nutrition and the Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Gangwon-do, Republic of Korea
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  surname: Kim
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Issue 3
Keywords ceramide
metabolic disease
sphingolipid
obesity
phytochemical
Language English
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Snippet The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in...
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SubjectTerms Body fat
Care and treatment
Ceramides
Ceramides - metabolism
Complications and side effects
Development and progression
Diet
Disease
Fatty acids
Gastrointestinal surgery
Health aspects
Human subjects
Humans
Inflammation
Insulin resistance
Insulin Resistance - physiology
Lipids
lipotoxicity
Liver
Metabolic diseases
Metabolic Diseases - complications
Metabolic disorders
Metabolism
Obesity
Obesity - metabolism
Pathogenesis
Physiological aspects
Phytochemicals
Review
Risk factors
risk reduction
Sphingolipids - metabolism
Tumor necrosis factor-TNF
Weight control
Title The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism
URI https://www.ncbi.nlm.nih.gov/pubmed/36771408
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Volume 15
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