Guillain Barre syndrome associated with COVID-19 infection: A case report

•A novel coronavirus (COVID-19) was detected in Wuhan City, Hubei Province of China.•The most symptoms of disease have reported fever, cough, dyspnea, myalgia, headache, and diarrhea.•We described GBS symptoms in one infected patient with COVID-19, for the first time.•The patient revealed quadripleg...

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Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 76; pp. 233 - 235
Main Authors: Sedaghat, Zahra, Karimi, Narges
Format: Journal Article
Language:English
Published: Scotland Elsevier Ltd 01.06.2020
Subjects:
Aged
Betacoronavirus
Case Report
Coronavirus Infections - complications
COVID-19
Guillain Barre syndrome
Guillain-Barre Syndrome - diagnosis
Guillain-Barre Syndrome - virology
Humans
Male
Neuropathy
Novel coronavirus
Pandemics
Pneumonia, Viral - complications
SARS-CoV-2
COVID-19
Case report
Neuropathy
Guillain Barre syndrome
Novel coronavirus
ISSN:0967-5868, 1532-2653, 1532-2653
Online Access:Get full text
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Summary:•A novel coronavirus (COVID-19) was detected in Wuhan City, Hubei Province of China.•The most symptoms of disease have reported fever, cough, dyspnea, myalgia, headache, and diarrhea.•We described GBS symptoms in one infected patient with COVID-19, for the first time.•The patient revealed quadriplegia and facial paresis bilaterally, two weeks after COVID-19 infection.•The electrodiagnostic findings of patient demonstrated acute motor sensory axonal polyneuropathy. Novel outbreak with coronavirus 2019 began since 31 December 2019. Coronaviruses can cause multiple systemic infections that respiratory complications are the most obvious symptoms. In this report, we describe the symptoms of Guillain Barre syndrome (GBS) in one infected patient with COVID-19, for the first time. We reported a 65-years- old male patient with complaints of acute progressive symmetric ascending quadriparesis. Two weeks prior to hospitalization, the patient suffered from cough, fever, and RT-PCR was reported positive for COVID-19 infection. The electrodiagnostic test showed that the patient is an AMSAN variant of GBS. COVID-19 stimulates inflammatory cells and produces various inflammatory cytokines and as a result, it creates immune-mediated processes. GBS is an immune-mediated disorder and molecular mimicry as a mechanism of autoimmune disorder plays an important role in creating it. It is unclear whether COVID-19 induces the production of antibodies against specific gangliosides. Further investigations should be conducted about the mechanism of GBS in patients with COVID-19, in the future.
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ISSN:0967-5868
1532-2653
1532-2653
DOI:10.1016/j.jocn.2020.04.062