FOXM1 confers acquired cisplatin resistance in breast cancer cells

The transcription factor Forkhead box M1 (FOXM1) is a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to uncontrolled cell division and genomic instability. To address the role of FOXM1 in chemoresistance, we generated a cisplatin-resistant breast c...

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Vydáno v:	Molecular cancer research Ročník 8; číslo 1; s. 24
Hlavní autoři:	Kwok, Jimmy M-M, Peck, Barrie, Monteiro, Lara J, Schwenen, Helma D C, Millour, Julie, Coombes, R Charles, Myatt, Stephen S, Lam, Eric W-F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2010
Témata:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Regulatory Proteins BRCA2 Protein - physiology Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cells, Cultured Cisplatin - therapeutic use DNA Damage - genetics DNA Repair - drug effects DNA Repair - genetics DNA-Binding Proteins - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Female Forkhead Box Protein M1 Forkhead Transcription Factors - chemistry Forkhead Transcription Factors - genetics Forkhead Transcription Factors - physiology Gene Expression Regulation, Neoplastic - drug effects Humans Mutant Proteins - genetics Mutant Proteins - physiology Protein Structure, Tertiary - genetics Protein Structure, Tertiary - physiology Signal Transduction - genetics Thiostrepton - pharmacology Up-Regulation X-ray Repair Cross Complementing Protein 1
ISSN:	1557-3125, 1557-3125
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