Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage

Acute leukemias of ambiguous lineage (ALAL), including mixed phenotype acute leukemia (MPAL) and related entities such as early T-cell precursor acute leukemia (ETP-ALL), remain diagnostic and clinical challenges due to limited understanding of pathogenesis, reliance of immunophenotyping to classify...

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Bibliographic Details
Published in:	Best practice & research. Clinical haematology Vol. 34; no. 4; p. 101329
Main Authors:	Montefiori, Lindsey E., Mullighan, Charles G.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.12.2021
Subjects:	14q32 ALAL BCL11B Child Enhancer hijacking Genomics Humans Immunophenotyping Lineage ambiguous Mixed phenotype acute leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma Prospective Studies Repressor Proteins Tumor Suppressor Proteins ALAL BCL11B Lineage ambiguous 14q32 Mixed phenotype acute leukemia Enhancer hijacking
ISSN:	1521-6926, 1532-1924, 1532-1924
Online Access:	Get full text
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