Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats

Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's p...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Renal failure Ročník 46; číslo 1; s. 2327495
Hlavní autori:	Zhang, Lei, Wang, Xingzhi, Chang, Liang, Ren, Yiqun, Sui, Manshu, Fu, Yuting, Hao, Lirong
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis Ltd 01.12.2024 Taylor & Francis Taylor & Francis Group
Predmet:	Animal models Basic Sciences Investigations Cell activation Cell culture Diabetes Diabetes mellitus Diabetic kidney disease (DKD) End-stage renal disease Epithelial cells Ferroptosis Flavonoids Kidney diseases Nrf2 Quercetin rat Streptozocin streptozotocin Diabetic kidney disease (DKD) quercetin ferroptosis rat streptozotocin Nrf2
ISSN:	0886-022X, 1525-6049, 1525-6049
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's progression, making its counteraction a potential therapeutic strategy. Quercetin, a flavonoid found in numerous fruits and vegetables, has demonstrated DKD mitigation in mouse models, though its protective mechanism remains ambiguous. In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both and , validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD treatment by modulating the ferroptosis process activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin's protective mechanisms.
AbstractList	Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's progression, making its counteraction a potential therapeutic strategy. Quercetin, a flavonoid found in numerous fruits and vegetables, has demonstrated DKD mitigation in mouse models, though its protective mechanism remains ambiguous. In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both in vivo and in vitro, validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD treatment by modulating the ferroptosis process via activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin's protective mechanisms.Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's progression, making its counteraction a potential therapeutic strategy. Quercetin, a flavonoid found in numerous fruits and vegetables, has demonstrated DKD mitigation in mouse models, though its protective mechanism remains ambiguous. In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both in vivo and in vitro, validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD treatment by modulating the ferroptosis process via activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin's protective mechanisms. Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's progression, making its counteraction a potential therapeutic strategy. Quercetin, a flavonoid found in numerous fruits and vegetables, has demonstrated DKD mitigation in mouse models, though its protective mechanism remains ambiguous. In this study, we delved into quercetin’s potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both in vivo and in vitro, validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin’s potential in DKD treatment by modulating the ferroptosis process via activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin’s protective mechanisms. Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's progression, making its counteraction a potential therapeutic strategy. Quercetin, a flavonoid found in numerous fruits and vegetables, has demonstrated DKD mitigation in mouse models, though its protective mechanism remains ambiguous. In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both and , validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD treatment by modulating the ferroptosis process activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin's protective mechanisms.
Author	Fu, Yuting Sui, Manshu Ren, Yiqun Hao, Lirong Wang, Xingzhi Chang, Liang Zhang, Lei
Author_xml	– sequence: 1 givenname: Lei surname: Zhang fullname: Zhang, Lei organization: Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China – sequence: 2 givenname: Xingzhi surname: Wang fullname: Wang, Xingzhi organization: Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China – sequence: 3 givenname: Liang surname: Chang fullname: Chang, Liang organization: Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China – sequence: 4 givenname: Yiqun surname: Ren fullname: Ren, Yiqun organization: Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China – sequence: 5 givenname: Manshu surname: Sui fullname: Sui, Manshu organization: Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China – sequence: 6 givenname: Yuting surname: Fu fullname: Fu, Yuting organization: Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China – sequence: 7 givenname: Lirong surname: Hao fullname: Hao, Lirong organization: Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China, Department of Nephropathy, Southern University of Science and Technology Hospital, Shenzhen, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38465879$$D View this record in MEDLINE/PubMed
BookMark	eNqFkktv1DAQxy1URB_wEUCRuHDJ4kz8iMUBVRWPShUIqQduluNMdr1k7cVOKi1nPjhOd1toL5zGnvnN3-OZOSVHPngk5GVFFxVt6FvaNIICfF8ABbaAGiRT_Ak5qTjwUlCmjsjJzJQzdExOU1pTWvFGwjNyXDdM5KM6Ib-_TRgtjs4XbrON4QZT0TnTZo8tfrjO4y7fE5qERbsrnF-51mV6WfQYY9iOIblUGN8VEZfTYG5D4wqLL7GHjBdpjJipX2EM1vnS-W6y2P19I5oxPSdPezMkfHGwZ-T644fri8_l1ddPlxfnV6XlVIwlNywnAe9aEKpqAKoWjeihbStoURjBACkazgVYpSjYhmYrkbOmEkbWZ-RyL9sFs9bb6DYm7nQwTt86QlxqE3NNA2rRo7SmZ2hpbqUyRgITKKWRTa_A8Kz1fq-1ndoNdhb9GM3wQPRhxLuVXoYbXVFV5zmwrPDmoBDDzwnTqDcuWRwG4zFMSYPiHATnakZfP0LXYYo-t0rXVNaMSaB1pl79W9J9LXfDzgDfAzaGlCL290hF9bxU-m6p9LxU-rBUOe_dozzrxjzpMP_MDf_J_gN6S9QM
CitedBy_id	crossref_primary_10_1016_j_phymed_2024_155738 crossref_primary_10_1016_j_phymed_2025_156945 crossref_primary_10_1002_ptr_70083 crossref_primary_10_1016_j_biopha_2025_118304 crossref_primary_10_3390_nu16203530 crossref_primary_10_1002_fsh3_12066 crossref_primary_10_3389_fphar_2025_1581632 crossref_primary_10_1002_slct_202500400 crossref_primary_10_1002_ptr_70059 crossref_primary_10_1155_2024_2177516 crossref_primary_10_2147_DMSO_S524983 crossref_primary_10_3390_cimb47090735 crossref_primary_10_1016_j_jep_2025_120157 crossref_primary_10_1002_cbf_70067 crossref_primary_10_1007_s10528_024_10871_w crossref_primary_10_1089_jmf_2024_k_0135 crossref_primary_10_1038_s41598_025_04679_w crossref_primary_10_1186_s13045_024_01564_3 crossref_primary_10_1002_ptr_70028 crossref_primary_10_1016_j_bbrc_2025_152500 crossref_primary_10_1002_ame2_70032 crossref_primary_10_3390_nu17162714 crossref_primary_10_1007_s00210_024_03742_z crossref_primary_10_3390_molecules29122832 crossref_primary_10_3390_ijms26157391 crossref_primary_10_3390_ijms26157471
Cites_doi	10.1080/21655979.2022.2045834 10.1681/ASN.2010010010 10.1038/ncb3064 10.1016/j.jare.2020.07.007 10.3748/wjg.v29.i20.3084 10.1016/j.biopha.2018.10.130 10.1007/s00018-017-2547-4 10.2337/db09-1342 10.1002/0471141755.ph0547s70 10.1016/j.redox.2019.101107 10.1271/bbb.67.2396 10.1016/j.jare.2021.06.023 10.1007/s12263-013-0361-7 10.1016/j.diabres.2021.109119 10.1142/S0192415X23500465 10.1155/2021/1497449 10.3389/fendo.2021.626390 10.4239/wjd.v1.i2.48 10.1056/NEJMoa1811744 10.1038/s41598-022-25739-5 10.1142/S0192415X22500537 10.1038/s41419-021-03452-x 10.1016/j.ejphar.2020.173574 10.1021/ja411006a 10.1021/acsomega.9b01142 10.1681/ASN.2009070721 10.3390/biomedicines10040891 10.3390/biom10020320 10.1016/j.intimp.2022.109162 10.1038/nchembio.2239 10.1016/j.fct.2022.112892 10.1016/j.cell.2012.03.042 10.1021/acsomega.0c01818 10.3390/molecules24061123 10.1038/nrdp.2015.18 10.1016/j.freeradbiomed.2020.10.323 10.4239/wjd.v5.i3.393 10.2337/dc14-S014 10.1038/s41467-021-24712-6 10.1093/ndt/gfv264 10.1038/s41422-020-00441-1 10.1111/jnc.14033 10.1016/s0014-5793(99)00696-1
ContentType	Journal Article
Copyright	2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2024 The Author(s)
Copyright_xml	– notice: 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2024 The Author(s)
DBID	AAYXX CITATION NPM 3V. 7T5 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH H94 K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA
DOI	10.1080/0886022X.2024.2327495
DatabaseName	CrossRef PubMed ProQuest Central (Corporate) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Research Library Research Library (Corporate) Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef PubMed Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Publicly Available Content Database PubMed
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Open Access Full Text url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
DocumentTitleAlternate	L. Zhang et al
EISSN	1525-6049
ExternalDocumentID	oai_doaj_org_article_6fe7caf4ec00499aa7246e77a78f92a5 PMC10930154 38465879 10_1080_0886022X_2024_2327495
Genre	Journal Article
GroupedDBID	--- 00X 0YH 123 29P 36B 4.4 53G 5RE 7X7 88E 8FI 8FJ 8G5 AAYXX ABDBF ABUWG ACGEJ ACGFS ACUHS ADBBV ADCVX ADRBQ ADXPE AENEX AFFHD AFKRA AFKVX AJWEG ALMA_UNASSIGNED_HOLDINGS AOIJS AQTUD ARJSQ AZQEC BABNJ BCNDV BENPR BLEHA CCPQU CITATION CS3 DWQXO EAP EBC EBD EBS EMB EMK EMOBN EPL ESX F5P FYUFA GNUQQ GROUPED_DOAJ GUQSH H13 HMCUK HZ~ M1P M2O M4Z O9- P2P PHGZM PHGZT PIMPY PJZUB PPXIY PROAC PSQYO RPM SV3 TDBHL TFDNU TFL TFW TUS UKHRP V1S ~1N .GJ 5VS AALIY AAORF AAPXX ABWCV AFLEI AJVHN AWYRJ BPHCQ BRMBE CAG COF CYYVM CZDIS DRXRE DWTOO EJD HYE JENTW M44 NPM NUSFT PQQKQ QQXMO ZGI ZXP 3V. 7T5 7XB 8FK H94 K9. MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c506t-5a4abe25db26918221bea6f2bb12be6a642e0ea5562c9902c80c997e54816a73
IEDL.DBID	BENPR
ISICitedReferencesCount	34
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001184011700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0886-022X 1525-6049
IngestDate	Fri Oct 03 12:45:22 EDT 2025 Tue Nov 04 02:06:11 EST 2025 Fri Sep 05 10:11:38 EDT 2025 Tue Oct 07 07:03:00 EDT 2025 Thu Apr 03 07:04:41 EDT 2025 Sat Nov 29 02:26:05 EST 2025 Tue Nov 18 22:35:55 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Diabetic kidney disease (DKD) quercetin ferroptosis rat streptozotocin Nrf2
Language	English
License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c506t-5a4abe25db26918221bea6f2bb12be6a642e0ea5562c9902c80c997e54816a73
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 This author contributed to this work as a lead contact. These author contributed to this work as a senior author.
OpenAccessLink	https://www.proquest.com/docview/3073447203?pq-origsite=%requestingapplication%
PMID	38465879
PQID	3073447203
PQPubID	3933335
ParticipantIDs	doaj_primary_oai_doaj_org_article_6fe7caf4ec00499aa7246e77a78f92a5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10930154 proquest_miscellaneous_2955265594 proquest_journals_3073447203 pubmed_primary_38465879 crossref_primary_10_1080_0886022X_2024_2327495 crossref_citationtrail_10_1080_0886022X_2024_2327495
PublicationCentury	2000
PublicationDate	2024-Dec
PublicationDateYYYYMMDD	2024-12-01
PublicationDate_xml	– month: 12 year: 2024 text: 2024-Dec
PublicationDecade	2020
PublicationPlace	England
PublicationPlace_xml	– name: England – name: New York
PublicationTitle	Renal failure
PublicationTitleAlternate	Ren Fail
PublicationYear	2024
Publisher	Taylor & Francis Ltd Taylor & Francis Taylor & Francis Group
Publisher_xml	– name: Taylor & Francis Ltd – name: Taylor & Francis – name: Taylor & Francis Group
References	e_1_3_2_27_1 e_1_3_2_28_1 e_1_3_2_29_1 e_1_3_2_42_1 e_1_3_2_20_1 e_1_3_2_41_1 e_1_3_2_44_1 e_1_3_2_22_1 e_1_3_2_43_1 e_1_3_2_23_1 e_1_3_2_24_1 e_1_3_2_45_1 e_1_3_2_25_1 e_1_3_2_26_1 e_1_3_2_40_1 e_1_3_2_16_1 e_1_3_2_39_1 e_1_3_2_9_1 e_1_3_2_17_1 e_1_3_2_38_1 e_1_3_2_8_1 e_1_3_2_18_1 e_1_3_2_7_1 e_1_3_2_19_1 e_1_3_2_2_1 e_1_3_2_31_1 e_1_3_2_30_1 e_1_3_2_10_1 e_1_3_2_33_1 e_1_3_2_11_1 e_1_3_2_32_1 e_1_3_2_6_1 e_1_3_2_12_1 e_1_3_2_35_1 e_1_3_2_5_1 e_1_3_2_13_1 e_1_3_2_34_1 e_1_3_2_4_1 e_1_3_2_14_1 e_1_3_2_37_1 e_1_3_2_3_1 e_1_3_2_15_1 e_1_3_2_36_1 Bryda EC. (e_1_3_2_21_1) 2013; 110
References_xml	– ident: e_1_3_2_39_1 doi: 10.1080/21655979.2022.2045834 – ident: e_1_3_2_5_1 doi: 10.1681/ASN.2010010010 – ident: e_1_3_2_12_1 doi: 10.1038/ncb3064 – ident: e_1_3_2_18_1 doi: 10.1016/j.jare.2020.07.007 – ident: e_1_3_2_41_1 doi: 10.3748/wjg.v29.i20.3084 – ident: e_1_3_2_36_1 doi: 10.1016/j.biopha.2018.10.130 – ident: e_1_3_2_11_1 doi: 10.1007/s00018-017-2547-4 – ident: e_1_3_2_45_1 doi: 10.2337/db09-1342 – ident: e_1_3_2_20_1 doi: 10.1002/0471141755.ph0547s70 – ident: e_1_3_2_31_1 doi: 10.1016/j.redox.2019.101107 – ident: e_1_3_2_24_1 doi: 10.1271/bbb.67.2396 – ident: e_1_3_2_43_1 doi: 10.1016/j.jare.2021.06.023 – ident: e_1_3_2_34_1 doi: 10.1007/s12263-013-0361-7 – ident: e_1_3_2_2_1 doi: 10.1016/j.diabres.2021.109119 – ident: e_1_3_2_15_1 doi: 10.1142/S0192415X23500465 – ident: e_1_3_2_8_1 doi: 10.1155/2021/1497449 – volume: 110 start-page: 207 issue: 3 year: 2013 ident: e_1_3_2_21_1 article-title: The mighty mouse: the impact of rodents on advances in biomedical research publication-title: Mo Med – ident: e_1_3_2_38_1 doi: 10.3389/fendo.2021.626390 – ident: e_1_3_2_3_1 doi: 10.4239/wjd.v1.i2.48 – ident: e_1_3_2_7_1 doi: 10.1056/NEJMoa1811744 – ident: e_1_3_2_35_1 doi: 10.1038/s41598-022-25739-5 – ident: e_1_3_2_37_1 doi: 10.1142/S0192415X22500537 – ident: e_1_3_2_13_1 doi: 10.1038/s41419-021-03452-x – ident: e_1_3_2_26_1 doi: 10.1016/j.ejphar.2020.173574 – ident: e_1_3_2_14_1 doi: 10.1021/ja411006a – ident: e_1_3_2_23_1 doi: 10.1021/acsomega.9b01142 – ident: e_1_3_2_19_1 doi: 10.1681/ASN.2009070721 – ident: e_1_3_2_29_1 doi: 10.3390/biomedicines10040891 – ident: e_1_3_2_44_1 doi: 10.3390/biom10020320 – ident: e_1_3_2_42_1 doi: 10.1016/j.intimp.2022.109162 – ident: e_1_3_2_30_1 doi: 10.1038/nchembio.2239 – ident: e_1_3_2_40_1 doi: 10.1016/j.fct.2022.112892 – ident: e_1_3_2_9_1 doi: 10.1016/j.cell.2012.03.042 – ident: e_1_3_2_16_1 doi: 10.1021/acsomega.0c01818 – ident: e_1_3_2_17_1 doi: 10.3390/molecules24061123 – ident: e_1_3_2_32_1 doi: 10.1038/nrdp.2015.18 – ident: e_1_3_2_25_1 doi: 10.1016/j.freeradbiomed.2020.10.323 – ident: e_1_3_2_6_1 doi: 10.4239/wjd.v5.i3.393 – ident: e_1_3_2_4_1 doi: 10.2337/dc14-S014 – ident: e_1_3_2_10_1 doi: 10.1038/s41467-021-24712-6 – ident: e_1_3_2_22_1 doi: 10.1093/ndt/gfv264 – ident: e_1_3_2_28_1 doi: 10.1038/s41422-020-00441-1 – ident: e_1_3_2_33_1 doi: 10.1111/jnc.14033 – ident: e_1_3_2_27_1 doi: 10.1016/s0014-5793(99)00696-1
SSID	ssj0015872
Score	2.527029
Snippet	Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy,...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	2327495
SubjectTerms	Animal models Basic Sciences Investigations Cell activation Cell culture Diabetes Diabetes mellitus Diabetic kidney disease (DKD) End-stage renal disease Epithelial cells Ferroptosis Flavonoids Kidney diseases Nrf2 Quercetin rat Streptozocin streptozotocin
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pi9UwEA6yiHgRf1tdJYLXrm2aJs1RxcWLD4U9vFtJ0oQNSrq0fcJ69g93pk2f74mwF0-FJqVp5kvzTWf6DSFvGgMk2XVdXlprc65rk6vKuFxZZazzpi58MRebkJtNs92qLwelvjAnbJEHXiburfBOWu25szM711oyLpyUWjZeMT2rlwLrWZ2pFD-om7lsEywhTLFl2_XfHVTVbrDsEtuCb8j4GRAKybG4xMGuNIv3_4tx_p04ebATnd8n9xKFpO-WoT8gt1x8SO58TkHyR-TX1x1mq0wh0jB_MnAjXT6xBku_hS66a5riMtRc0xAvgwmY_Uy9G4b-aurHMFIdOzosheqxCXgi3QyeQXeK_5dAr5_9BJaNOXj1gI_uzz0AVONjcnH-8eLDpzwVW8htXYgprzWHTqzuwHgKnA5WGqeFZ8aUzDihwU9xhdM18CULOxizTQFH6cDjKYWW1RNyEvvonhHKvNClEUxp77ixorEVFxW3VdcUytsuI3yd69YmIXKsh_G9LVe90mSiFk3UJhNl5Gx_2dWixHHTBe_RkPvOKKQ9nwB4tQle7U3wysjpCoM2re6xxfci5xjAzsjrfTOsSwy26Oj63dgyVWPlgVrxjDxdULMfSQWkDxCqMtIc4eloqMctMVzO2t-o_oW09_n_eLgX5C5O2JKdc0pOpmHnXpLb9scUxuHVvKJ-A7_gJZ4 priority: 102 providerName: Directory of Open Access Journals
Title	Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats
URI	https://www.ncbi.nlm.nih.gov/pubmed/38465879 https://www.proquest.com/docview/3073447203 https://www.proquest.com/docview/2955265594 https://pubmed.ncbi.nlm.nih.gov/PMC10930154 https://doaj.org/article/6fe7caf4ec00499aa7246e77a78f92a5
Volume	46
WOSCitedRecordID	wos001184011700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: DOA dateStart: 20160101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: 7X7 dateStart: 20171101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: BENPR dateStart: 20171101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research library customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: M2O dateStart: 20171101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: PIMPY dateStart: 20171101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAWR databaseName: Taylor & Francis Journals Complete customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: TFW dateStart: 20170101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis – providerCode: PRVAWR databaseName: Taylor & Francis Open Access customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: 0YH dateStart: 19870101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Nb9MwFLdYhxAXvj8KYzIS14zEceL4hBjaBIeWgnYop8h2HGaBnJKkSOPMH857idutCMGBSyLFTuLEP9vvy-9HyItCg5BsqypKjDERV5mOZKptJI3UxtY6i-t4IJsQ83mxXMpFMLh1IaxyMycOE3XVGLSRv0Qsco5Ow1erbxGyRqF3NVBo7JF9zFTGJ2T_-GS--Lj1I2TFQN8EQwlDbdlys4cHs2sXSL_ElqAjMn4EgoXgSDJxZXUakvj_SfL8PYDyyop0evt_v-UOuRVkUfp6BM9dcs36e-TGLHjb75OfH9YY9tI7T91ge7AdHW21ztAvrvL2ggYHD9UX1Plzpx2GUdPatm2z6pvOdVT5irYj4z0WgcBJ523NoDrFjSpQ60fTA0R85HwFQKsu3wHo7B6Qs9OTszdvo8DaEJkszvsoUxwqsawCFEjQXliircprpnXCtM0VKDw2tioDwcvAUshMEcNZWFCdklyJ9CGZ-Mbbx4SyOleJzplUteXa5IVJeZ5yk1ZFLGtTTQnfdFZpQkZzJNb4WiabxKehj0vs4zL08ZQcbW9bjSk9_nXDMSJhWxkzcg8XmvZzGQZ4mddWGFVzawYtUinBeG6FUKKoJVPwkIMNFsowTXTlJRCm5Pm2GAY4em2Ut826K5nMkMIgk3xKHo2w27YkBekRIC6npNgB5E5Td0u8Ox-SiGMaMZSfn_y9XU_JTfwVYwDPAZn07do-I9fN99517SHZE0sxHIvDMPQOB6sGHGfsPVxbvJstPv0C2PQ5tg
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKFgEX3pSFAkaCY9rEcR4-IMSr6qrd1SLtYTlZtuO0FpWzJFnQcubv8B8Z57HtIgSnHjhFWjuJ5f1m8tkzng-hF6kEkqyzzAuUUh4VkfRYKLXHFJNK5zLyc78Rm0gmk3Q-Z9Mt9LM_C-PSKnuf2DjqrFBuj3zfYZFSFzR8vfjiOdUoF13tJTRaWBzp1TdYslWvRu_h_31JyMGH2btDr1MV8FTkx7UXCSqkJlEGo2TArkkgtYhzImVApI4FEHLtaxEBMVDgqolKfbgmGqh9EIskhMdeQdsUsJ4O0PZ0NJ5-WoctorRRiwLLdZm9ZN4fGXLFvFOn9kTmsCQldA94TEKdpsWFj2GjGfAnovt7vuaFD-DBrf9s6m6jmx3Txm9a07iDtrS9i66Nu1yCe-jHx6VL6qmNxabZWdEVbneijcKfTWb1CnfhKyxX2NhTI41LEse5LstiUReVqbCwGS71SSOCBk1Ap_GkzAl0x-4YDvT6XtRgANYzNgMzys7fAbZX3Uezy5iCB2hgC6sfIkzyWAQyJkzkmkoVpyqkcUhVmKU-y1U2RLTHBlddvXYnG3LGg76sawcp7iDFO0gN0d76tkVbsORfN7x1wFt3dvXGmx-K8oR37ovHuU6UyKlWzRpZiITQWCeJSNKcEQEP2e2hxzsnWPFz3A3R83UzuC8XkxJWF8uKExY5gYaI0SHaaVG-HkkI3Bgsig1RuoH_jaFutlhz2pRId0XS3Org0d_H9QxdP5yNj_nxaHL0GN1w09KmKu2iQV0u9RN0VX2tTVU-7SwdI37JBvILdrqPyg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quercetin+improves+diabetic+kidney+disease+by+inhibiting+ferroptosis+and+regulating+the+Nrf2+in+streptozotocin-induced+diabetic+rats&rft.jtitle=Renal+failure&rft.au=Zhang%2C+Lei&rft.au=Wang%2C+Xingzhi&rft.au=Chang%2C+Liang&rft.au=Ren%2C+Yiqun&rft.date=2024-12-01&rft.pub=Taylor+%26+Francis+Ltd&rft.issn=0886-022X&rft.eissn=1525-6049&rft.volume=46&rft.issue=1&rft_id=info:doi/10.1080%2F0886022X.2024.2327495
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0886-022X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0886-022X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0886-022X&client=summon