Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression

The estrogen receptor (ER) suppresses transcriptional activity of the RelA subunit of nuclear factor-kappaB in a hormone-dependent manner by a mechanism involving both the receptor DNA binding domain and ligand binding domain (LBD). In this study we examine the role of the ER LBD in mediating ligand...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 275; no. 33; p. 25322
Main Authors:	Valentine, J E, Kalkhoven, E, White, R, Hoare, S, Parker, M G
Format:	Journal Article
Language:	English
Published:	United States 18.08.2000
Subjects:	Animals Blotting, Western COS Cells Cyclic AMP Response Element-Binding Protein - metabolism Dimerization Estradiol - pharmacology Glutathione Transferase - metabolism HeLa Cells Humans Ligands Ligases - antagonists & inhibitors Ligases - metabolism Mutagenesis, Site-Directed Mutation NF-kappa B - antagonists & inhibitors Nuclear Proteins - metabolism Plasmids - metabolism Point Mutation Protein Structure, Tertiary Receptors, Estrogen - chemistry Receptors, Estrogen - genetics Trans-Activators - metabolism Transcription, Genetic Transcriptional Activation Transfection
ISSN:	0021-9258
Online Access:	Get more information
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