A study of the genetic variability of human respiratory syncytial virus (HRSV) in Cambodia reveals the existence of a new HRSV group B genotype

Human respiratory syncytial virus (HRSV) is the leading cause of hospitalization of children aged <5 years due to respiratory illness in industrialized countries, and pneumonia is the leading cause of mortality among children aged <5 years worldwide. Although HRSV was first identified in 1956,...

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Published in:Journal of clinical microbiology Vol. 49; no. 10; p. 3504
Main Authors: Arnott, Alicia, Vong, Sirenda, Mardy, Sek, Chu, Simon, Naughtin, Monica, Sovann, Ly, Buecher, Carole, Beauté, Julien, Rith, Sareth, Borand, Laurence, Asgari, Nima, Frutos, Roger, Guillard, Bertrand, Touch, Sok, Deubel, Vincent, Buchy, Philippe
Format: Journal Article
Language:English
Published: United States 01.10.2011
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Cambodia - epidemiology
Child
Child, Preschool
Cluster Analysis
Female
Genetic Variation
Genotype
Humans
Infant
Infant, Newborn
Male
Middle Aged
Molecular Epidemiology
Molecular Sequence Data
Phylogeny
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - classification
Respiratory Syncytial Virus, Human - genetics
Respiratory Syncytial Virus, Human - isolation & purification
RNA, Viral - genetics
Seasons
Sequence Analysis, DNA
Young Adult
Cambodia
ISSN:1098-660X, 1098-660X
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Summary:Human respiratory syncytial virus (HRSV) is the leading cause of hospitalization of children aged <5 years due to respiratory illness in industrialized countries, and pneumonia is the leading cause of mortality among children aged <5 years worldwide. Although HRSV was first identified in 1956, a preventative vaccine has yet to be developed. Here we report the results of the first study to investigate the circulation and genetic diversity of HRSV in Cambodia among an all-ages population over 5 consecutive years. The incidences of HRSV infection among all-ages outpatient and hospitalized populations were equivalent, at 9.5% and 8.2%, respectively. Infection was most prevalent among children aged <5 years, with bronchiolitis being the most frequently observed clinical syndrome in the same age group. Circulation of HRSV was seasonal, typically coinciding with the rainy season between July and November annually. Strains belonging to HRSV groups A and B were detected with equivalent frequencies; however, we observed a potentially biennial shift in the predominant circulating HRSV genotype. The majority of HRSV group B strains belonged to the recently described BA genotype, with the exception of 10 strains classified as belonging to a novel HRSV group B genotype, SAB4, first reported here.
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ISSN:1098-660X
1098-660X
DOI:10.1128/JCM.01131-11