Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious assays or indirect reporter read-outs. Here we descri...

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Vydané v:	eLife Ročník 5
Hlavní autori:	Vlaming, Hanneke, Molenaar, Thom M, van Welsem, Tibor, Poramba-Liyanage, Deepani W, Smith, Desiree E, Velds, Arno, Hoekman, Liesbeth, Korthout, Tessy, Hendriks, Sjoerd, Altelaar, AF Maarten, van Leeuwen, Fred
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England eLife Science Publications, Ltd 06.12.2016 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Predmet:	Acetyltransferase Adenosine Adenosine kinase Cancer Chromatin Chromatin - chemistry Chromatin Immunoprecipitation Clinical trials Deoxyribonucleic acid DNA DNA methylation DNA repair DNA sequencing DNA, Fungal - chemistry DNA, Fungal - genetics DNA, Fungal - metabolism Dot1 Enzymes Epigenetics Experiments Gene Expression Regulation, Fungal Genes and Chromosomes Genetic aspects Genetic Testing Genetics, Microbial - methods Genomes H3K79 methylation histone modifications Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Homologous recombination Immunoprecipitation Laboratories Library collections Mass spectrometry Methionine Methods Methylation Molecular Biology - methods Nuclear Proteins - metabolism Nucleotide sequencing Observations Peptides Physiological aspects Protein Processing, Post-Translational Proteins Proteomics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - metabolism SAGA Scientific imaging Sequence Analysis, DNA Tools and Resources Ubiquitination Yeast fungi adenosine kinase genes chromosomes Dot1 histone modifications DNA repair H3K79 methylation SAGA S. cerevisiae
ISSN:	2050-084X, 2050-084X
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