HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes

Human leukocyte antigens of class-I (HLA-I) molecules are hyper-expressed in insulin-containing islets (ICI) of type 1 diabetic (T1D) donors. This study investigated the HLA-I expression in autoantibody positive (AAB+) donors and defined its intra-islet and intracellular localization as well as prox...

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Veröffentlicht in:	Journal of autoimmunity Jg. 119; S. 102628
Hauptverfasser:	Benkahla, Mehdi A., Sabouri, Somayeh, Kiosses, William B., Rajendran, Sakthi, Quesada-Masachs, Estefania, von Herrath, Matthias G.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.05.2021
Schlagworte:	Alpha cells Autoantibodies - immunology Autoantigens - immunology Autoimmunity Beta cells Biomarkers Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - metabolism Disease Susceptibility - immunology Fluorescent Antibody Technique Gene Expression Glucagon-Secreting Cells - metabolism Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HLA class I Humans Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Islets of Langerhans - immunology Islets of Langerhans - metabolism Islets of Langerhans - pathology nPOD Prediabetic State - etiology Prediabetic State - immunology Protein Transport T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Type 1 diabetes Beta cells HLA class I nPOD Type 1 diabetes Alpha cells
ISSN:	0896-8411, 1095-9157, 1095-9157
Online-Zugang:	Volltext
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