CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells

Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased CD47 expression on human AML LSC contributes to pathogenesis by inhibiting their phagocytosis through the interaction of C...

Full description

Bibliographic Details

Published in:	Cell Vol. 138; no. 2; p. 286
Main Authors:	Majeti, Ravindra, Chao, Mark P, Alizadeh, Ash A, Pang, Wendy W, Jaiswal, Siddhartha, Gibbs, Jr, Kenneth D, van Rooijen, Nico, Weissman, Irving L
Format:	Journal Article
Language:	English
Published:	United States 23.07.2009
Subjects:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use CD47 Antigen - immunology CD47 Antigen - metabolism Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - therapy Mice Phagocytosis Prognosis Receptors, Immunologic - immunology Receptors, Immunologic - metabolism
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!