CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells

Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased CD47 expression on human AML LSC contributes to pathogenesis by inhibiting their phagocytosis through the interaction of C...

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Vydané v:	Cell Ročník 138; číslo 2; s. 286
Hlavní autori:	Majeti, Ravindra, Chao, Mark P, Alizadeh, Ash A, Pang, Wendy W, Jaiswal, Siddhartha, Gibbs, Jr, Kenneth D, van Rooijen, Nico, Weissman, Irving L
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 23.07.2009
Predmet:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use CD47 Antigen - immunology CD47 Antigen - metabolism Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - therapy Mice Phagocytosis Prognosis Receptors, Immunologic - immunology Receptors, Immunologic - metabolism
ISSN:	1097-4172, 1097-4172
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