Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to drug resistance such as increased drug efflux, altered drug metabolism, secondary mutations in drug targets, and activation of d...

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Veröffentlicht in:	Drug resistance updates Jg. 15; H. 1-2; S. 21 - 38
Hauptverfasser:	Wilting, Roel H., Dannenberg, Jan-Hermen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Scotland Elsevier Ltd 01.02.2012
Schlagworte:	Acetylation Acquired drug resistance Animals Antineoplastic Agents - therapeutic use Cell Transformation, Neoplastic - genetics DNA Methylation Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epigenesis, Genetic Epigenetic therapy Epigenetics Gene Expression Regulation, Neoplastic - drug effects Genetic Heterogeneity Hematology, Oncology and Palliative Medicine Histones - genetics Histones - metabolism Humans Infectious Disease Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Oncogenic histone modifications Signal Transduction - drug effects Signal Transduction - genetics Tumor heterogeneity Tumor heterogeneity Epigenetics Epigenetic therapy Acquired drug resistance Oncogenic histone modifications
ISSN:	1368-7646, 1532-2084, 1532-2084
Online-Zugang:	Volltext
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