Polystyrene microplastics mediate cell cycle arrest, apoptosis, and autophagy in the G2/M phase through ROS in grass carp kidney cells

Microplastics (MPs) have attracted widespread worldwide attention as a new pollutant. However, the role of reactive oxygen species (ROS) and cell cycle in nephrotoxicity induced by different concentrations of polystyrene microplastics (PS‐MPs) is unknown. This study used grass carp kidney cells (CIK...

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Bibliographic Details
Published in:	Environmental toxicology Vol. 39; no. 4; pp. 1923 - 1935
Main Authors:	Lu, Hongmin, Hou, Lulu, Zhang, Yue, Guo, Tiantian, Wang, Yu, Xing, Mingwei
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.04.2024 Wiley Subscription Services, Inc
Subjects:	Adenosine diphosphate ADP Animals antioxidant activity Apoptosis apoptosis and autophagy Autophagy B-lymphocytes Bcl-2 protein Biology Carp Caspase 3 - metabolism Caspase-3 Caspase-9 Cell cycle Cell Cycle Checkpoints Cell Division Cells CIK cells Ctenopharyngodon idella cyclin-dependent kinase Cytochrome c Cytochromes ecotoxicology G2/M cell cycle arrest Glutathione Humans Kidney - metabolism Kidneys Kinases Lymphoma Malondialdehyde Microplastics Microplastics - toxicity mitosis nephrotoxicity Oxidative stress Plastic pollution Plastics - pharmacology pollutants Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Polystyrene polystyrene microplastic Polystyrene resins polystyrenes Polystyrenes - toxicity Protein-serine/threonine kinase Reactive oxygen species Reactive Oxygen Species - metabolism Ribose ROS Serine Superoxide dismutase Threonine Toxicology CIK cells apoptosis and autophagy polystyrene microplastic ROS G2/M cell cycle arrest
ISSN:	1520-4081, 1522-7278, 1522-7278
Online Access:	Get full text
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