Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

Cardiovascular risk in diabetes remains elevated despite glucose-lowering therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages, promoting persistent proatherogenic characteristics. Bone marrow-derived macrophages from control mice and mice with diabetes were grown in...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 144; no. 12; p. 961
Main Authors:	Edgar, Laurienne, Akbar, Naveed, Braithwaite, Adam T, Krausgruber, Thomas, Gallart-Ayala, Héctor, Bailey, Jade, Corbin, Alastair L, Khoyratty, Tariq E, Chai, Joshua T, Alkhalil, Mohammad, Rendeiro, André F, Ziberna, Klemen, Arya, Ritu, Cahill, Thomas J, Bock, Christoph, Laurencikiene, Jurga, Crabtree, Mark J, Lemieux, Madeleine E, Riksen, Niels P, Netea, Mihai G, Wheelock, Craig E, Channon, Keith M, Rydén, Mikael, Udalova, Irina A, Carnicer, Ricardo, Choudhury, Robin P
Format:	Journal Article
Language:	English
Published:	United States 21.09.2021
Subjects:	Animals Atherosclerosis - immunology Atherosclerosis - pathology Cells, Cultured Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Endarterectomy, Carotid Humans Hyperglycemia - immunology Hyperglycemia - pathology Immunity, Cellular - immunology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - pathology Macrophages - immunology Macrophages - pathology Mice Mice, 129 Strain Mice, Transgenic glucose macrophages diabetes mellitus inflammation epigenetics
ISSN:	1524-4539, 1524-4539
Online Access:	Get more information
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