HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured. Animal models for the study of CRC-induced cachexia, in particular mo...

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Bibliographic Details
Published in:	Disease models & mechanisms Vol. 13; no. 1
Main Authors:	Huot, Joshua R., Novinger, Leah J., Pin, Fabrizio, Bonetto, Andrea
Format:	Journal Article
Language:	English
Published:	England The Company of Biologists Ltd 01.01.2020 The Company of Biologists
Subjects:	Animals cachexia Cachexia - etiology Colorectal cancer Colorectal Neoplasms - complications Colorectal Neoplasms - pathology Cytokines - blood Disease Models, Animal hct116 HCT116 Cells Humans Interleukin-6 - physiology Liver liver metastases Liver Neoplasms - secondary Male Metastasis Mice Mitochondria, Muscle - metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Musculoskeletal system skeletal muscle stat3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - physiology Tumors Wasting Syndrome - etiology HCT116 Liver metastases Cachexia Skeletal muscle Colorectal cancer STAT3
ISSN:	1754-8403, 1754-8411, 1754-8411
Online Access:	Get full text
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