SLCO1B1 : Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function

( ) is an important transmembrane hepatic uptake transporter. Genetic variants in the gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation sequencing (NGS) of pharmacogenes is being applied increasingly to associ...

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Vydané v:	Drug metabolism and disposition Ročník 49; číslo 5; s. 395
Hlavní autori:	Zhang, Lingxin, Sarangi, Vivekananda, Ho, Ming-Fen, Moon, Irene, Kalari, Krishna R, Wang, Liewei, Weinshilboum, Richard M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.05.2021
Predmet:	Genetic Variation - genetics Genomics - methods HEK293 Cells Humans Liver-Specific Organic Anion Transporter 1 - genetics Mutation, Missense - genetics
ISSN:	1521-009X, 1521-009X
On-line prístup:	Zistit podrobnosti o prístupe
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