Dual role of autophagy in hallmarks of cancer

Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and superfluous cellular proteins, organelles, and other cytoplasmic components. Mechanistically, it involves formation of double-membrane vesicles...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncogene Jg. 37; H. 9; S. 1142 - 1158
Hauptverfasser: Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.03.2018
Nature Publishing Group
Schlagworte:
631/67/2327
631/80/39
Animals
Apoptosis
Autophagy
Autophagy (Cytology)
Cancer
Carcinogenesis
Care and treatment
Cell Biology
Cell Transformation, Neoplastic - pathology
Cytoplasm
Eukaryotes
Health aspects
Human Genetics
Humans
Internal Medicine
Lysosomes
Medicine
Medicine & Public Health
Membrane vesicles
Neoplasms - pathology
Neurodegeneration
Oncology
Organelles
Phagocytosis
Phagosomes
Physiological aspects
Review Article
Tumor suppression
Tumorigenesis
Singapore
ISSN:0950-9232, 1476-5594, 1476-5594
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and superfluous cellular proteins, organelles, and other cytoplasmic components. Mechanistically, it involves formation of double-membrane vesicles called autophagosomes that capture cytosolic cargo and deliver it to lysosomes, wherein the breakdown products are eventually recycled back to the cytoplasm. Dysregulation of autophagy often results in various disease manifestations, including neurodegeneration, microbial infections, and cancer. In the case of cancer, extensive attention has been devoted to understanding the paradoxical roles of autophagy in tumor suppression and tumor promotion. In this review, while we summarize how this self-eating process is implicated at various stages of tumorigenesis, most importantly, we address the link between autophagy and hallmarks of cancer. This would eventually provide a better understanding of tumor dependence on autophagy. We also discuss how therapeutics targeting autophagy can counter various transformations involved in tumorigenesis. Finally, this review will provide a novel insight into the mutational landscapes of autophagy-related genes in several human cancers, using genetic information collected from an array of cancers.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Literature Review-3
ObjectType-Review-3
content type line 23
ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/s41388-017-0046-6