Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma

There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AA...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 77; H. 22; S. 6119
Hauptverfasser:	Sivakumar, Smruthy, Lucas, F Anthony San, McDowell, Tina L, Lang, Wenhua, Xu, Li, Fujimoto, Junya, Zhang, Jianjun, Futreal, P Andrew, Fukuoka, Junya, Yatabe, Yasushi, Dubinett, Steven M, Spira, Avrum E, Fowler, Jerry, Hawk, Ernest T, Wistuba, Ignacio I, Scheet, Paul, Kadara, Humam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.11.2017
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Aged Disease Progression Female Gene Expression Profiling Genomics Humans Hyperplasia - genetics Lung - metabolism Lung - pathology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Mutation Precancerous Conditions - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
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