The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family ha...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Frontiers in oncology Ročník 12; s. 985363
Hlavní autoři:	Qian, Shanna, Wei, Zhong, Yang, Wanting, Huang, Jinling, Yang, Yinfeng, Wang, Jinghui
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Frontiers Media S.A 12.10.2022
Témata:	apoptosis autoimmunity Bcl-2 cancer Oncology systematic
ISSN:	2234-943X, 2234-943X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.
AbstractList	Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer. Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.
Author	Wei, Zhong Yang, Wanting Huang, Jinling Wang, Jinghui Qian, Shanna Yang, Yinfeng
AuthorAffiliation	1 School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine , Hefei , China 3 School of Medical Informatics Engineering, Anhui University of Chinese Medicine , Hefei , China 2 Gastrointestinal Surgery, Anhui Provincial Hospital , Hefei , China
AuthorAffiliation_xml	– name: 1 School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine , Hefei , China – name: 3 School of Medical Informatics Engineering, Anhui University of Chinese Medicine , Hefei , China – name: 2 Gastrointestinal Surgery, Anhui Provincial Hospital , Hefei , China
Author_xml	– sequence: 1 givenname: Shanna surname: Qian fullname: Qian, Shanna – sequence: 2 givenname: Zhong surname: Wei fullname: Wei, Zhong – sequence: 3 givenname: Wanting surname: Yang fullname: Yang, Wanting – sequence: 4 givenname: Jinling surname: Huang fullname: Huang, Jinling – sequence: 5 givenname: Yinfeng surname: Yang fullname: Yang, Yinfeng – sequence: 6 givenname: Jinghui surname: Wang fullname: Wang, Jinghui
BookMark	eNp1kc2LFDEQxYOs4Lru3WOOXnrMZ3dyEXTwY2HAywreQpKunsmSSdokI8x_b7eziCuYS4VUvV-98F6iq5QTIPSakg3nSr-dcvIbRhjbaCV5z5-ha8a46LTg36_-ur9At7U-kOX0klDCr9Hu_gC45Ag4T_jDdtcxPNljiGc8l9wgpIpDwgX2p2hbSHts5zy3XEPFNo3Y2-Sh4HaAYufzK_R8srHC7WO9Qd8-fbzfful2Xz_fbd_vOi-JbJ1WxDqnHAiilCKUSSZAasWocoOkg_OjtLpnwk-9kz0BPoDyTMGotXPa8Rt0d-GO2T6YuYSjLWeTbTC_H3LZG1ta8BFMr5RmA1GTpl54kFYu36ZO0MWK0ANZWO8urPnkjjB6SK3Y-AT6tJPCwezzT6OlXsyyBfDmEVDyjxPUZo6heojRJsinatjASS-k1OsouYz6kmstMP1ZQ4lZgzRrkGYN0lyCXCT9PxIf2pJEXs2E-H_hL6swpK8
CitedBy_id	crossref_primary_10_1016_j_prp_2024_155478 crossref_primary_10_1007_s11030_024_11000_w crossref_primary_10_1016_j_bbrc_2025_151287 crossref_primary_10_1016_j_ijbiomac_2025_144190 crossref_primary_10_3390_ijms25031421 crossref_primary_10_1038_s41598_025_93344_3 crossref_primary_10_3389_fimmu_2025_1543145 crossref_primary_10_1016_j_bcp_2025_116827 crossref_primary_10_1016_j_cellsig_2024_111329 crossref_primary_10_3390_ijms26157082 crossref_primary_10_1016_j_toxrep_2025_102031 crossref_primary_10_1002_slct_202302948 crossref_primary_10_1016_j_urolonc_2025_06_001 crossref_primary_10_3390_ijms25179463 crossref_primary_10_1002_ange_202309043 crossref_primary_10_1016_j_bbrc_2025_152001 crossref_primary_10_1007_s13402_024_01024_7 crossref_primary_10_3390_photonics10040464 crossref_primary_10_3390_nu16172953 crossref_primary_10_3390_molecules30071411 crossref_primary_10_3390_pharmaceutics16091120 crossref_primary_10_1016_j_molstruc_2025_141424 crossref_primary_10_38124_ijisrt_25jul270 crossref_primary_10_3390_cancers15143593 crossref_primary_10_1080_10406638_2025_2457951 crossref_primary_10_1089_ars_2023_0491 crossref_primary_10_3390_vetsci12030265 crossref_primary_10_1089_ars_2023_0250 crossref_primary_10_1016_j_cbi_2025_111667 crossref_primary_10_1016_j_drudis_2023_103808 crossref_primary_10_1016_j_bmc_2025_118364 crossref_primary_10_1021_acsabm_5c00779 crossref_primary_10_1080_23723556_2025_2518679 crossref_primary_10_1016_j_bbcan_2025_189377 crossref_primary_10_1134_S1607672924600313 crossref_primary_10_1007_s11033_024_09737_6 crossref_primary_10_1016_j_ijbiomac_2025_145142 crossref_primary_10_1016_j_jff_2025_106991 crossref_primary_10_1080_15376516_2024_2438120 crossref_primary_10_1007_s10495_025_02161_6 crossref_primary_10_1007_s13205_025_04250_4 crossref_primary_10_4103_NRR_NRR_D_24_01459 crossref_primary_10_1007_s12032_025_02888_x crossref_primary_10_3390_ph16101392 crossref_primary_10_1007_s11060_025_05089_8 crossref_primary_10_1007_s00210_025_04487_z crossref_primary_10_1016_j_tibs_2025_01_007 crossref_primary_10_1080_15287394_2024_2368619 crossref_primary_10_3390_biom14121596 crossref_primary_10_1038_s41589_023_01463_7 crossref_primary_10_20517_2394_4722_2025_07 crossref_primary_10_3390_molecules28145305 crossref_primary_10_1155_2024_8481761 crossref_primary_10_1016_j_envpol_2024_123997 crossref_primary_10_71150_jm_2412012 crossref_primary_10_3390_cancers17152491 crossref_primary_10_1016_j_ijbiomac_2024_137106 crossref_primary_10_3390_microorganisms12081606 crossref_primary_10_1002_jbio_202400071 crossref_primary_10_1016_j_compbiolchem_2024_108329 crossref_primary_10_1016_j_bbcan_2025_189395 crossref_primary_10_2131_jts_50_387 crossref_primary_10_1002_cam4_70987 crossref_primary_10_1556_2060_2025_00641 crossref_primary_10_1002_1878_0261_70002 crossref_primary_10_1016_j_carbpol_2025_123735 crossref_primary_10_3892_mmr_2025_13432 crossref_primary_10_2147_OTT_S537872 crossref_primary_10_1080_15538362_2024_2427123 crossref_primary_10_3390_ph17070912 crossref_primary_10_3390_molecules29173994 crossref_primary_10_1038_s41598_025_87445_2 crossref_primary_10_3390_ijms26115369 crossref_primary_10_1016_j_bioorg_2024_107644 crossref_primary_10_3389_fnagi_2025_1571563 crossref_primary_10_3390_molecules29194697 crossref_primary_10_3389_fncel_2024_1458720 crossref_primary_10_3390_cimb46060368 crossref_primary_10_1016_j_intimp_2024_113768 crossref_primary_10_1007_s12013_025_01816_0 crossref_primary_10_1016_j_rechem_2025_102442 crossref_primary_10_1007_s10811_025_03652_4 crossref_primary_10_3390_biomedicines11092531 crossref_primary_10_1097_MD_0000000000042392 crossref_primary_10_3390_ijms25053027 crossref_primary_10_1002_ptr_70075 crossref_primary_10_1016_j_chemosphere_2024_143012 crossref_primary_10_3390_ph18070960 crossref_primary_10_1007_s12032_025_02646_z crossref_primary_10_1016_j_colsurfa_2025_137400 crossref_primary_10_3390_medicina61010136 crossref_primary_10_34133_research_0723 crossref_primary_10_7759_cureus_89916 crossref_primary_10_1007_s12032_024_02539_7 crossref_primary_10_1016_j_jep_2024_118689 crossref_primary_10_1039_D5NJ00670H crossref_primary_10_3390_biomedicines13071745 crossref_primary_10_1016_j_bbrc_2025_152113 crossref_primary_10_1007_s12011_024_04400_4 crossref_primary_10_1186_s42269_025_01353_z crossref_primary_10_1016_j_biopha_2023_115931 crossref_primary_10_3390_cancers15174267 crossref_primary_10_1016_j_bmc_2025_118299 crossref_primary_10_1186_s42047_024_00153_5 crossref_primary_10_3389_fphar_2023_1291920 crossref_primary_10_3390_ijms26010238 crossref_primary_10_3389_fchem_2025_1565699 crossref_primary_10_3892_mmr_2025_13537 crossref_primary_10_7759_cureus_58091 crossref_primary_10_3390_ijms24054961 crossref_primary_10_1002_cbin_70004 crossref_primary_10_1002_chem_202403026 crossref_primary_10_1016_j_jff_2025_106799 crossref_primary_10_1038_s41419_024_06524_w crossref_primary_10_1038_s41598_025_88572_6 crossref_primary_10_3390_cancers16050984 crossref_primary_10_1007_s11030_024_11079_1 crossref_primary_10_1016_j_yexcr_2025_114688 crossref_primary_10_3390_ijms25136937 crossref_primary_10_1038_s41598_025_85691_y crossref_primary_10_3390_plants14152449 crossref_primary_10_1007_s11033_025_10385_7 crossref_primary_10_1016_j_jinorgbio_2025_112988 crossref_primary_10_1007_s42247_023_00572_2 crossref_primary_10_1007_s10637_024_01473_9 crossref_primary_10_1038_s41598_024_65968_4 crossref_primary_10_1007_s44345_025_00023_x crossref_primary_10_3390_medicina60122110 crossref_primary_10_3892_mmr_2025_13661 crossref_primary_10_1007_s10787_025_01839_2 crossref_primary_10_1080_15384047_2024_2432690 crossref_primary_10_7759_cureus_75779 crossref_primary_10_3390_cells13090786 crossref_primary_10_1016_j_compbiolchem_2025_108427 crossref_primary_10_1016_j_cbi_2024_111147 crossref_primary_10_1038_s41598_024_58108_5 crossref_primary_10_1016_j_prmcm_2025_100648 crossref_primary_10_1016_j_leukres_2024_107610 crossref_primary_10_3389_fimmu_2024_1337478 crossref_primary_10_3389_fphar_2024_1404172 crossref_primary_10_1016_j_ejphar_2024_177222 crossref_primary_10_3390_antiox12091730 crossref_primary_10_3390_v17030390 crossref_primary_10_1002_cbdv_202402872 crossref_primary_10_1007_s00210_024_03095_7 crossref_primary_10_1093_toxres_tfae028 crossref_primary_10_1016_j_ijbiomac_2024_135362 crossref_primary_10_3390_antiox14010108 crossref_primary_10_1186_s13046_025_03505_5 crossref_primary_10_1186_s12935_024_03463_6 crossref_primary_10_1038_s41598_025_13201_1 crossref_primary_10_1021_acsomega_5c04198 crossref_primary_10_3390_cimb47080660 crossref_primary_10_3390_ijms26178506 crossref_primary_10_1186_s12943_025_02386_8 crossref_primary_10_3390_pharmaceutics16050654 crossref_primary_10_1186_s12885_025_13796_8 crossref_primary_10_3390_ph17010088 crossref_primary_10_1016_j_biopha_2024_117429 crossref_primary_10_1016_j_fct_2024_115097 crossref_primary_10_3390_cimb47090698 crossref_primary_10_1002_cbdv_202401673 crossref_primary_10_1007_s00210_025_04154_3 crossref_primary_10_69601_meandrosmdj_1591577 crossref_primary_10_1016_j_sajb_2024_07_061 crossref_primary_10_1016_j_taap_2025_117498 crossref_primary_10_1002_mc_23908 crossref_primary_10_3390_biom14050544 crossref_primary_10_1167_iovs_66_3_28 crossref_primary_10_3390_cancers17183031 crossref_primary_10_1007_s11802_025_5990_0 crossref_primary_10_1016_j_scitotenv_2024_175984 crossref_primary_10_1002_ddr_70037 crossref_primary_10_1007_s12668_024_01643_2 crossref_primary_10_1021_polymscitech_4c00026 crossref_primary_10_1080_10408398_2024_2398636 crossref_primary_10_3390_ph18091410 crossref_primary_10_1016_j_ejphar_2025_177965 crossref_primary_10_1016_j_bioorg_2025_108150 crossref_primary_10_1002_jha2_849 crossref_primary_10_1088_1402_4896_ad8aa7 crossref_primary_10_1016_j_prp_2024_155170 crossref_primary_10_1007_s11033_025_10864_x crossref_primary_10_1007_s00210_025_03962_x crossref_primary_10_1016_j_jddst_2024_106556 crossref_primary_10_1021_acsapm_5c00608 crossref_primary_10_3390_cells13030268 crossref_primary_10_3389_fphar_2023_1194861 crossref_primary_10_1007_s11684_024_1090_6 crossref_primary_10_4236_jbm_2025_137033 crossref_primary_10_1016_j_jksus_2023_102932 crossref_primary_10_3389_fimmu_2024_1410150 crossref_primary_10_1007_s12032_025_02980_2 crossref_primary_10_3389_fonc_2024_1371057 crossref_primary_10_1186_s12951_023_02218_1 crossref_primary_10_1016_j_phyplu_2024_100721 crossref_primary_10_3390_ph18010098 crossref_primary_10_3389_fphys_2025_1536165 crossref_primary_10_3390_molecules28134947 crossref_primary_10_3390_ijms26167965 crossref_primary_10_1007_s12010_025_05360_8 crossref_primary_10_1002_ajoc_70161 crossref_primary_10_1016_j_mtcomm_2024_109214 crossref_primary_10_1016_j_molstruc_2025_142815 crossref_primary_10_1038_s41598_025_07642_x crossref_primary_10_1002_cmdc_202400847 crossref_primary_10_13005_bpj_2806 crossref_primary_10_1002_cbf_3909 crossref_primary_10_1038_s41598_025_16692_0 crossref_primary_10_1177_09731296241275740 crossref_primary_10_1016_j_jafr_2025_102360 crossref_primary_10_1038_s41598_025_93620_2 crossref_primary_10_1038_s41598_025_00983_7 crossref_primary_10_1016_j_jsps_2024_101971 crossref_primary_10_1007_s11033_023_09002_2 crossref_primary_10_1016_j_sajb_2023_05_025 crossref_primary_10_3390_jox15020045 crossref_primary_10_3390_ph18060895 crossref_primary_10_1038_s41598_025_95447_3 crossref_primary_10_1016_j_arcmed_2024_103122 crossref_primary_10_1007_s12602_025_10539_w crossref_primary_10_1039_D4RA03963G crossref_primary_10_1134_S160767292460043X crossref_primary_10_3389_fmicb_2024_1485667 crossref_primary_10_1016_j_isci_2024_109979 crossref_primary_10_1039_D4RA06146B crossref_primary_10_3390_jfb16090352 crossref_primary_10_1186_s12906_025_04782_5 crossref_primary_10_3390_molecules30071576 crossref_primary_10_1007_s00011_024_01866_9 crossref_primary_10_3390_molecules30071453 crossref_primary_10_1016_j_critrevonc_2025_104895 crossref_primary_10_3390_ani14030386 crossref_primary_10_25259_SNI_176_2024 crossref_primary_10_1155_2024_4972523 crossref_primary_10_3390_cells13221838 crossref_primary_10_3390_ijms25116255 crossref_primary_10_3390_cancers16142609 crossref_primary_10_3389_fchem_2024_1427797 crossref_primary_10_1016_j_bbrc_2024_150495 crossref_primary_10_1016_j_ejphar_2024_177129 crossref_primary_10_1016_j_cellsig_2025_111982 crossref_primary_10_1016_j_molstruc_2024_140783 crossref_primary_10_1021_jacs_5c09544 crossref_primary_10_1002_prp2_70142 crossref_primary_10_1007_s10068_024_01787_7 crossref_primary_10_1016_j_bioorg_2024_107942 crossref_primary_10_1016_j_toxlet_2025_05_003 crossref_primary_10_3390_ph17091129 crossref_primary_10_1002_cmdc_202500265 crossref_primary_10_1007_s13596_025_00840_y crossref_primary_10_3390_ijms26083852 crossref_primary_10_3390_molecules29081789 crossref_primary_10_1007_s11010_024_05136_4 crossref_primary_10_1016_j_hermed_2023_100837 crossref_primary_10_1208_s12249_024_02906_7 crossref_primary_10_1016_j_biopha_2024_117449 crossref_primary_10_1016_j_envres_2025_122328 crossref_primary_10_1080_09205063_2025_2491605 crossref_primary_10_1016_j_biopha_2025_117986 crossref_primary_10_1080_22311866_2023_2278726 crossref_primary_10_1016_j_ejphar_2025_177779 crossref_primary_10_1007_s10695_025_01577_w crossref_primary_10_1126_scisignal_adp6006 crossref_primary_10_1177_09731296241264612 crossref_primary_10_3390_jcm14186465 crossref_primary_10_3390_biology14060690 crossref_primary_10_3390_cells13131083 crossref_primary_10_1016_j_sjbs_2023_103916 crossref_primary_10_3390_nu16081237 crossref_primary_10_3390_toxins16080356 crossref_primary_10_1002_cnr2_70074 crossref_primary_10_1016_j_medmic_2025_100140 crossref_primary_10_3390_ijms25189939 crossref_primary_10_1038_s41598_024_52167_4 crossref_primary_10_3390_ijms241310420 crossref_primary_10_1002_cam4_71270 crossref_primary_10_1007_s11033_024_09655_7 crossref_primary_10_1002_cbdv_202402599 crossref_primary_10_1016_j_molstruc_2025_143150 crossref_primary_10_1016_j_cca_2024_119687 crossref_primary_10_1016_j_foodres_2025_116178 crossref_primary_10_3390_life13112213 crossref_primary_10_1016_j_jbc_2024_108025 crossref_primary_10_1016_j_poly_2025_117560 crossref_primary_10_1016_j_neuro_2024_08_003 crossref_primary_10_1002_jssc_202300678 crossref_primary_10_1016_j_prp_2025_156036 crossref_primary_10_1016_j_fsi_2024_109910 crossref_primary_10_1016_j_ccr_2025_217052 crossref_primary_10_1007_s11010_024_05010_3 crossref_primary_10_1016_j_jhazmat_2024_136835 crossref_primary_10_1016_j_phymed_2025_157290 crossref_primary_10_3390_molecules30030666 crossref_primary_10_1002_mco2_575 crossref_primary_10_3390_ani15131910 crossref_primary_10_1016_j_molstruc_2024_140959 crossref_primary_10_1186_s41110_025_00366_y crossref_primary_10_3390_microorganisms12040839 crossref_primary_10_3390_life14091074 crossref_primary_10_1002_mco2_693 crossref_primary_10_1007_s00432_025_06210_0 crossref_primary_10_1016_j_amolm_2025_100094 crossref_primary_10_1515_jcim_2025_0118 crossref_primary_10_1038_s41598_023_35453_5 crossref_primary_10_3390_biomedicines12102201 crossref_primary_10_1002_bab_2750 crossref_primary_10_3389_fonc_2025_1547636 crossref_primary_10_1007_s12032_025_02814_1 crossref_primary_10_1016_j_psj_2025_104965 crossref_primary_10_1002_idm2_70000 crossref_primary_10_3390_molecules30153193 crossref_primary_10_1016_j_bpj_2024_08_017 crossref_primary_10_3389_fphar_2024_1483856 crossref_primary_10_1158_2767_9764_CRC_25_0096 crossref_primary_10_1007_s12032_025_02947_3 crossref_primary_10_1016_j_phymed_2024_155902 crossref_primary_10_1007_s11010_024_05199_3 crossref_primary_10_1021_acs_jmedchem_5c01372 crossref_primary_10_3389_fgene_2024_1502152 crossref_primary_10_1038_s41392_024_01823_2 crossref_primary_10_1002_slct_202501985 crossref_primary_10_1016_j_aquatox_2025_107468 crossref_primary_10_1016_j_molstruc_2025_143069 crossref_primary_10_1002_jbt_70475 crossref_primary_10_3892_ol_2024_14447 crossref_primary_10_3390_md23050187 crossref_primary_10_30872_jsk_v5i5_539 crossref_primary_10_1016_j_bioorg_2025_108211 crossref_primary_10_1111_jcmm_70052 crossref_primary_10_31083_j_fbl2808185 crossref_primary_10_3390_pr11092771 crossref_primary_10_1097_MOH_0000000000000846 crossref_primary_10_1016_j_cellsig_2024_111089 crossref_primary_10_1016_j_heliyon_2024_e31414 crossref_primary_10_1021_acs_jmedchem_5c00486 crossref_primary_10_1016_j_bcp_2025_117278 crossref_primary_10_4103_jomfp_jomfp_299_23 crossref_primary_10_1002_adbi_202500136 crossref_primary_10_1002_mgg3_70054 crossref_primary_10_1016_j_arabjc_2024_105725 crossref_primary_10_3390_cancers16142544 crossref_primary_10_1007_s12013_025_01876_2 crossref_primary_10_1038_s41598_023_49637_6 crossref_primary_10_3390_biochem5030024 crossref_primary_10_3389_fimmu_2024_1375143 crossref_primary_10_3390_jcm13072046 crossref_primary_10_1007_s10924_023_02865_3 crossref_primary_10_1007_s12032_025_02903_1 crossref_primary_10_1016_j_micpath_2025_107633 crossref_primary_10_1016_j_clbc_2024_12_008 crossref_primary_10_1039_D5RA03747F crossref_primary_10_1038_s41420_024_01992_7 crossref_primary_10_1038_s41420_024_02148_3 crossref_primary_10_3390_ani15121808 crossref_primary_10_1007_s00210_025_04078_y crossref_primary_10_1007_s00210_025_04381_8 crossref_primary_10_1111_cbdd_14454 crossref_primary_10_1007_s11033_024_09284_0 crossref_primary_10_1007_s12975_025_01352_2 crossref_primary_10_20935_AcadMolBioGen7755 crossref_primary_10_1016_j_fsi_2025_110362 crossref_primary_10_3390_cells14090636 crossref_primary_10_1097_MD_0000000000040529 crossref_primary_10_3390_cimb47060460 crossref_primary_10_3390_ph17081039 crossref_primary_10_1007_s12282_024_01625_y crossref_primary_10_1038_s41375_025_02756_7 crossref_primary_10_18006_2025_13_2__137_150 crossref_primary_10_1007_s12013_024_01405_7 crossref_primary_10_1016_j_acthis_2025_152254 crossref_primary_10_1002_ardp_70021 crossref_primary_10_1016_j_bmcl_2024_129853 crossref_primary_10_1016_j_phymed_2025_157212 crossref_primary_10_3390_biom14111387 crossref_primary_10_1007_s12013_024_01286_w crossref_primary_10_1016_j_ica_2024_122136 crossref_primary_10_1016_j_ejmech_2024_117143 crossref_primary_10_1016_j_ejmech_2024_117023 crossref_primary_10_1007_s00421_025_05787_1 crossref_primary_10_1016_j_sajb_2024_10_021 crossref_primary_10_1177_09731296251313618 crossref_primary_10_1007_s10876_025_02854_7 crossref_primary_10_2147_JIR_S521756 crossref_primary_10_1038_s41598_025_16783_y crossref_primary_10_1016_j_cbpc_2025_110265 crossref_primary_10_1007_s12032_025_02839_6 crossref_primary_10_1089_ten_tea_2024_0025 crossref_primary_10_1002_mog2_70027 crossref_primary_10_1016_j_abb_2025_110306 crossref_primary_10_1002_jemt_70049 crossref_primary_10_1007_s00210_024_03191_8 crossref_primary_10_1016_j_bmcl_2023_129549 crossref_primary_10_1051_bioconf_202518401015 crossref_primary_10_1093_lifemedi_lnad019 crossref_primary_10_1007_s00210_025_03975_6 crossref_primary_10_1007_s10616_024_00654_x crossref_primary_10_56082_annalsarscibio_2025_1_185 crossref_primary_10_25259_JLP_45_2024 crossref_primary_10_4155_fmc_2023_0126 crossref_primary_10_3390_ijms252111713 crossref_primary_10_1016_j_omtn_2023_102053 crossref_primary_10_58985_jpam_2024_v02i02_21 crossref_primary_10_1053_j_jepm_2025_05_002 crossref_primary_10_1371_journal_pone_0328000 crossref_primary_10_1016_j_intimp_2025_115234 crossref_primary_10_3390_molecules29194770 crossref_primary_10_1016_j_jff_2023_105840 crossref_primary_10_3390_jcm13237131 crossref_primary_10_3390_medicina61060960 crossref_primary_10_1007_s12035_025_04833_5 crossref_primary_10_1088_1748_605X_add2b9 crossref_primary_10_1007_s12033_023_00909_6 crossref_primary_10_1038_s41598_024_78958_3 crossref_primary_10_1016_j_intimp_2024_111945 crossref_primary_10_3390_molecules30020346 crossref_primary_10_1007_s00210_025_03836_2 crossref_primary_10_2147_DDDT_S543211 crossref_primary_10_1186_s13287_024_03935_6 crossref_primary_10_1038_s41598_025_02178_6 crossref_primary_10_3390_pharmaceutics17080977 crossref_primary_10_3390_ph16071039 crossref_primary_10_3390_ijms25158252 crossref_primary_10_3390_ijms25126529 crossref_primary_10_1002_cnr2_70249 crossref_primary_10_1177_09603271251322531 crossref_primary_10_3390_ijms242015185 crossref_primary_10_1021_acsomega_5c01251 crossref_primary_10_1016_j_biopha_2025_118363 crossref_primary_10_1158_1078_0432_CCR_23_1525 crossref_primary_10_3390_ijms25179277 crossref_primary_10_1016_j_fbio_2024_104321 crossref_primary_10_3389_fphar_2024_1331843 crossref_primary_10_1177_09731296251348751 crossref_primary_10_1016_j_scitotenv_2024_177003 crossref_primary_10_1186_s12906_023_04120_7 crossref_primary_10_3389_fnut_2024_1370951 crossref_primary_10_3390_ijms26178280 crossref_primary_10_1016_j_molstruc_2025_142128 crossref_primary_10_1007_s00210_025_03901_w crossref_primary_10_1007_s12013_024_01608_y crossref_primary_10_2174_0109298673298420240530093525 crossref_primary_10_1016_j_bioorg_2025_108712 crossref_primary_10_1515_oncologie_2025_0056 crossref_primary_10_1158_1078_0432_CCR_24_2548 crossref_primary_10_1038_s41417_025_00953_1 crossref_primary_10_3390_cells13151266 crossref_primary_10_1039_D4RA03157A crossref_primary_10_1016_j_tiv_2024_105945 crossref_primary_10_1016_j_isci_2024_111231 crossref_primary_10_1371_journal_pone_0296312 crossref_primary_10_29219_fnr_v69_10764 crossref_primary_10_2174_0109298673343133241011072425 crossref_primary_10_3390_biomedicines11061758 crossref_primary_10_3390_ijms241813949 crossref_primary_10_3390_cancers17081381 crossref_primary_10_1007_s11033_025_10682_1 crossref_primary_10_4103_jiaomr_jiaomr_119_24 crossref_primary_10_1016_j_bioorg_2025_108962 crossref_primary_10_1016_j_tranon_2025_102483 crossref_primary_10_1002_anie_202309043 crossref_primary_10_1002_mco2_710 crossref_primary_10_1016_j_enceco_2025_08_008 crossref_primary_10_1002_cbin_70071 crossref_primary_10_1016_j_prp_2025_155954 crossref_primary_10_3390_biomedicines11061585 crossref_primary_10_7759_cureus_76221 crossref_primary_10_3390_sports12050116 crossref_primary_10_1016_j_ymthe_2025_08_034 crossref_primary_10_1016_j_prp_2024_155792 crossref_primary_10_26538_tjnpr_v9i8_49 crossref_primary_10_1007_s10495_025_02081_5 crossref_primary_10_1080_21645515_2025_2488074 crossref_primary_10_1007_s11030_025_11156_z crossref_primary_10_3390_life14101289 crossref_primary_10_3390_ijms26094173 crossref_primary_10_1016_j_foodchem_2025_143869 crossref_primary_10_1007_s00210_024_03519_4 crossref_primary_10_3390_foods14030356 crossref_primary_10_1111_cpr_13773 crossref_primary_10_1007_s00044_025_03459_5 crossref_primary_10_1016_j_ibreh_2025_100042 crossref_primary_10_3389_fncel_2024_1336145 crossref_primary_10_22141_2224_0713_21_1_2025_1157 crossref_primary_10_1016_j_ijbiomac_2025_140729 crossref_primary_10_1002_aro2_70032 crossref_primary_10_3390_antiox13060657 crossref_primary_10_1007_s12013_024_01507_2 crossref_primary_10_1016_j_molstruc_2025_143531 crossref_primary_10_37349_ei_2025_1003216 crossref_primary_10_1038_s41571_025_01068_0 crossref_primary_10_1177_11795549241298541 crossref_primary_10_1002_bab_2719 crossref_primary_10_1016_j_micpath_2023_106470 crossref_primary_10_1111_febs_70002 crossref_primary_10_3390_antiox13050504 crossref_primary_10_1002_jbt_70036 crossref_primary_10_3390_cancers16132478 crossref_primary_10_3390_ijms252212387 crossref_primary_10_1186_s13058_023_01758_6 crossref_primary_10_1177_09731296241281854 crossref_primary_10_1016_j_heliyon_2024_e34075 crossref_primary_10_1016_j_theriogenology_2025_117442 crossref_primary_10_3390_ani14152156 crossref_primary_10_1186_s12935_024_03548_2 crossref_primary_10_3390_ph17040484 crossref_primary_10_3892_br_2024_1918 crossref_primary_10_1080_20565623_2025_2461956 crossref_primary_10_1016_j_cbi_2024_111304
Cites_doi	10.1016/j.ejmech.2022.114327 10.3892/ol.2021.13072 10.1038/nrm2308 10.1242/dev.120.10.3033 10.3390/ijms221910442 10.1016/j.chembiol.2020.04.004 10.3390/ijms21093385 10.1016/s0092-8674(00)00080-5 10.1023/a:1009616228304 10.1002/cbic.202000473 10.1016/j.molcel.2011.10.001 10.1016/j.ejmech.2019.05.019 10.1038/s41419-018-0464-6 10.1038/s41388-021-02161-1 10.1016/S0002-9440(10)64557-9 10.1016/j.bcp.2017.03.006 10.3390/biom10121638 10.1038/s41420-021-00748-x 10.1093/emboj/17.2.384 10.1038/onc.2012.318 10.1016/j.bbrc.2021.02.049 10.7554/eLife.37689 10.3390/v13071374 10.1007/s11033-020-05933-2 10.1080/03602530701468516 10.1016/j.bbamcr.2013.06.001 10.1038/cdd.2011.17 10.1096/fj.201801417R 10.1038/s41418-019-0327-4 10.12688/f1000research.25607.1 10.1038/sj.onc.1210028 10.1016/s0005-2728(98)00112-1 10.1016/j.tcm.2013.06.007 10.1038/s41388-020-1212-9 10.1016/j.bbrc.2020.12.019 10.1016/j.molcel.2021.08.018 10.1158/0008-5472.CAN-19-1555 10.3324/haematol.2017.184192 10.1016/S1097-2765(01)00214-3 10.1016/bs.acr.2017.11.001 10.1007/s00204-014-1448-7 10.1016/bs.ircmb.2019.12.005 10.3390/molecules24213896 10.1155/2012/856029 10.1016/j.biopha.2020.110040 10.1002/jcp.27905 10.4103/1673-5374.286946 10.1016/j.bbrc.2017.06.190 10.1016/j.coi.2007.05.004 10.1038/s41419-017-0140-2 10.1073/pnas.94.23.12401 10.2174/1381612043384664 10.1038/s41418-020-00604-y 10.1038/s41418-018-0183-7 10.1016/j.biocel.2010.12.014 10.1158/1078-0432.CCR-08-0144 10.7150/thno.49860 10.1002/jcp.28936 10.1038/nrc3237 10.1158/1535-7163.MCT-09-0493 10.3390/molecules27020536 10.1038/onc.2015.287 10.1042/EBC20170104 10.1158/0008-5472.CAN-04-4570 10.3390/v14050922 10.15252/msb.20177974 10.1021/acschemneuro.8b00356 10.1186/s13058-015-0533-z 10.1111/febs.14186 10.1097/MOH.0000000000000433 10.1186/1476-4598-2-6 10.1002/jcp.29610 10.1111/febs.13624 10.3389/fonc.2022.869672 10.1038/s41571-020-0341-y 10.3390/life12020256 10.1038/sj.cdd.4400835 10.1371/journal.pone.0259447 10.2174/1389203721666191227122252 10.1096/fj.08-111005 10.1016/j.bbamcr.2003.08.012 10.1186/s12885-019-6169-0 10.1111/j.1600-065X.2010.00919.x 10.1111/jpi.12264 10.1007/s00005-012-0205-y 10.1007/s10549-009-0343-z 10.1186/s12885-017-3383-5 10.1158/1078-0432.CCR-06-0147 10.4103/2395-3977.177558 10.1101/gad.182100 10.1016/j.bbrc.2019.11.185 10.1007/s001090000099 10.1158/2159-8290.CD-18-1119 10.1038/s41598-019-53695-0 10.1083/jcb.148.5.857 10.1038/nature12477 10.1007/s10495-007-0749-1 10.1016/j.molcel.2020.05.029 10.1016/j.cellsig.2020.109772 10.1186/s12935-018-0538-7 10.1158/1078-0432.CCR-07-2184 10.1080/10428194.2017.1283032 10.1016/S0165-7208(00)80030-6 10.3109/10428194.2015.1030638 10.1038/cdd.2017.183 10.1038/sj.cdd.4401638 10.3748/wjg.v7.i3.403 10.7150/ijbs.40756 10.2147/OTT.S152818 10.18632/oncotarget.27488 10.1055/s-2004-818408 10.1021/acsomega.1c03385 10.1007/BF00196695 10.1080/22221751.2022.2026739 10.1016/j.yexmp.2021.104660 10.7573/dic.212574 10.1007/s10637-020-00931-4 10.1038/s41418-020-00716-5 10.3390/nu10081021 10.1016/j.molcel.2004.10.028 10.1186/s13578-019-0289-8 10.1038/s41575-019-0229-4 10.1038/s41418-021-00922-9 10.1007/978-1-4899-0274-0_10 10.3390/ijms20092234 10.1053/j.seminoncol.2003.08.015 10.18053/jctres.04.201801.005 10.1053/j.gastro.2016.11.048 10.1093/carcin/bgx016 10.21203/rs.3.rs-936588/v1 10.1083/jcb.201102027 10.1016/j.bbamcr.2010.12.019 10.1038/s41375-018-0223-9 10.3389/fonc.2018.00636 10.5483/bmbrep.2008.41.1.011 10.1016/j.dld.2018.09.021 10.2196/17695 10.15252/embj.2020105753 10.1182/blood-2018-02-791350 10.1038/s41580-018-0089-8 10.1126/science.3874430 10.1016/j.pharmthera.2018.10.009 10.1182/blood.V86.5.1903.bloodjournal8651903 10.1016/j.cophys.2018.03.005 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 10.1182/blood-2014-03-560284 10.1007/s10495-021-01667-z 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J 10.1038/sj.cr.7290052 10.1038/s41419-020-2417-0 10.1016/j.drudis.2020.07.021 10.1038/s41598-020-70636-4 10.1074/jbc.M008171200 10.1016/S0014-5793(00)01921-9 10.1158/1541-7786.MCR-18-0055 10.1098/rsob.180002 10.1007/s00018-021-03771-4 10.3233/CBM-201497 10.1161/CIRCRESAHA.111.243162 10.1038/nm.3048 10.1038/sj.bjc.6601095
ContentType	Journal Article
Copyright	Copyright © 2022 Qian, Wei, Yang, Huang, Yang and Wang. Copyright © 2022 Qian, Wei, Yang, Huang, Yang and Wang 2022 Qian, Wei, Yang, Huang, Yang and Wang
Copyright_xml	– notice: Copyright © 2022 Qian, Wei, Yang, Huang, Yang and Wang. – notice: Copyright © 2022 Qian, Wei, Yang, Huang, Yang and Wang 2022 Qian, Wei, Yang, Huang, Yang and Wang
DBID	AAYXX CITATION 7X8 5PM DOA
DOI	10.3389/fonc.2022.985363
DatabaseName	CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic CrossRef
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2234-943X
ExternalDocumentID	oai_doaj_org_article_68892708f91c4ce5a51031b41c504970 PMC9597512 10_3389_fonc_2022_985363
GroupedDBID	53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM 7X8 5PM
ID	FETCH-LOGICAL-c505t-980abb8be40888012524e598218b7517bcd5a9624cf6b560e37e8c28ed99bb9b3
IEDL.DBID	DOA
ISICitedReferencesCount	599
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000876910600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2234-943X
IngestDate	Fri Oct 03 12:47:41 EDT 2025 Thu Aug 21 18:39:00 EDT 2025 Fri Sep 05 09:46:29 EDT 2025 Sat Nov 29 01:50:48 EST 2025 Tue Nov 18 22:16:59 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c505t-980abb8be40888012524e598218b7517bcd5a9624cf6b560e37e8c28ed99bb9b3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Gavin P. McStay, Liverpool John Moores University, United Kingdom Reviewed by: Jiann-Ruey Hong, National Cheng Kung University, Taiwan; Dharmendra Kumar Yadav, Gachon University, South Korea; Manzar Alam, University of Texas Southwestern Medical Center, United States This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology
OpenAccessLink	https://doaj.org/article/68892708f91c4ce5a51031b41c504970
PQID	2730645592
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_68892708f91c4ce5a51031b41c504970 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9597512 proquest_miscellaneous_2730645592 crossref_primary_10_3389_fonc_2022_985363 crossref_citationtrail_10_3389_fonc_2022_985363
PublicationCentury	2000
PublicationDate	2022-10-12
PublicationDateYYYYMMDD	2022-10-12
PublicationDate_xml	– month: 10 year: 2022 text: 2022-10-12 day: 12
PublicationDecade	2020
PublicationTitle	Frontiers in oncology
PublicationYear	2022
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	Roufayel (B70) 2022; 12 Janaghard (B151) 2021 Buja (B6) 2021; 121 Chang (B118) 2000; 10 Arbab (B27) 2012; 2012 Opydo-Chanek (B161) 2020; 38 Alexandrov (B13) 2013; 500 Chen (B57) 2022; 14 Dai (B55) 2011; 194 Varela (B165) 2020; 10 Maji (B115) 2018; 137 Luna-Vargas (B5) 2016; 283 Puccetti (B107) 2018 Zhou (B121) 2019; 234 Yang (B163) 2019; 177 Han (B97) 2021; 548 Sun (B102) 2021; 16 Matthew-Onabanjo (B76) 2020; 80 Hung (B90) 2021; 28 Hsu (B66) 1997; 94 Ishida (B99) 1996; 428 Roberts (B148) 2021; 29 Pinton (B25) 2000; 148 Guicciardi (B137) 2009; 23 Peña-Blanco (B56) 2018; 285 Martin (B123) 2003; 89 Simon (B132) 2000; 5 Luo (B59) 2020; 9 Arisan (B166) 2010; 119 Campbell (B3) 2018; 8 Schneider (B136) 2000; 31 Buljan (B14) 2018; 14 Knittel (B108) 2018; 25 Ramachandran (B87) 2018; 4 Kipps (B156) 2015; 56 Gong (B40) 2013; 32 Zhu (B38) 2020; 25 Bose (B8) 2017; 58 Hauseman (B52) 2020; 79 Lee (B29) 2019; 20 Fridman (B72) 2001; 276 Tahir (B16) 2017; 17 Bergamini (B130) 2004; 10 de Charette (B106) 2018; 103 Kelly (B146) 2011; 18 Youle (B9) 2008; 9 Adams (B98) 2007; 19 Rasmussen (B158) 2020; 353 Li (B95) 2021; 11 Alam (B124) 2022; 12 Jeong (B142) 2008; 41 Sirotković-Skerlev (B105) 2021; 30 Wang (B153) 2003; 30 Craig (B113) 2020; 17 Yin (B86) 2000; 78 Hoppe (B33) 2000; 102 Mei (B83) 2020; 11 Matuszyk (B84) 2020; 235 Carneiro (B4) 2020; 17 Vanneman (B149) 2012; 12 Liu (B45) 2021; 22 Zhang (B71) 2020; 523 Choi (B18) 2005; 65 Ayllón (B36) 2002; 32 Sun (B93) 2020; 20 Lindenboim (B73) 2005; 12 Xu (B100) 2001; 7 Merino (B103) 2016; 35 Wang (B119) 2019; 234 Saha (B96) 2021; 7 Opydo-Chanek (B160) 2017; 136 Petros (B20) 2004; 1644 Flores-Romero (B61) 2020; 39 Jeng (B53) 2018; 3 Gabellini (B21) 2017; 38 Schulman (B68) 2019; 26 Jackson (B63) 2000; 14 Singh (B1) 2019; 20 Tsujimoto (B144) 1985; 228 Zheng (B92) 2020; 21 Kerr (B143) 1993; 73 Bessou (B31) 2020; 39 Chaabane (B127) 2013; 61 Nazeri (B42) 2020; 47 Kalpage (B139) 2019; 33 Mao (B155) 2022; 11 Xia (B138) 2019; 9 Park (B26) 2021; 16 Valentin (B7) 2018; 132 Llambi (B147) 2011; 44 Chauhan (B35) 2007; 26 Montero (B74) 2018; 25 Walsh (B128) 2010; 236 González-García (B30) 1994; 120 Li (B94) 2021; 26 Suraweera (B145) 2021; 13 Reed (B19) 1996; 406 Lee (B54) 2021; 534 Liu (B75) 2018; 10 Liu (B82) 2019; 8 Schulman (B67) 2019; 26 Reilly (B39) 2001; 8 Lohitesh (B114) 2018; 18 Westphal (B64) 2003; 2 Caro-Gómez (B44) 2019; 24 Boac (B78) 2019; 9 Meng (B135) 2020; 21 Yoshioka (B134) 2014; 24 Liao (B117) 2019; 51 Quemener (B157) 2022; 27 Hartman (B32) 2020; 11 Imre (B58) 2020; 76 Frangogiannis (B126) 2012; 110 Kang (B10) 2009; 15 Gibson (B34) 1996; 13 Yamaguchi (B41) 2019; 195 Lennicke (B131) 2021; 81 O’Reilly (B81) 2000; 157 Kim (B141) 2018; 10 Hantusch (B50) 2018; 9 Sia (B112) 2017; 152 Chen (B120) 2020; 22 Alam (B150) 2021; 22 Blombery (B17) 2019; 9 Luo (B77) 2021; 22 Meinhardt (B122) 2022; 41 Westphal (B80) 2011; 1813 Nikoletopoulou (B2) 2013; 1833 O’Connor (B37) 1998; 17 Fresquet (B15) 2014; 123 Cartron (B48) 2004; 16 Kondo (B62) 2000; 60 Juárez-Salcedo (B159) 2019; 8 Raha (B104) 2015; 17 Wu (B79) 2020; 126 Dai (B23) 2016; 2 Ilkhomovna (B101) 2021; 1 Harvey (B43) 2020; 27 Dadsena (B22) 2021; 78 Edlich (B51) 2018; 500 Lim (B85) 2021; 28 Tilokani (B24) 2018; 62 Reddy (B152) 2021; 6 Lemasters (B129) 1998; 1366 Hammerschmidt (B125) 2004; 58 Siddiqui (B28) 2015; 89 Shalaby (B69) 2020; 10 Nakano (B91) 2001; 7 Liu (B116) 2018; 11 Simonin (B167) 2009; 8 Kathania (B46) 2011; 43 Minn (B11) 1995; 86 Fernández (B140) 2015; 59 Lalier (B49) 2007; 12 Zhang (B60) 2000; 480 Bubendorf (B111) 1996; 148 Souers (B162) 2013; 19 Yoshino (B12) 2006; 12 Liu (B110) 2020; 16 Feng (B47) 2022; 114327 Carberry (B65) 2018; 9 Orrenius (B133) 2007; 39 Adams (B109) 2019; 8 Greaves (B88) 2019; 26 Verdine (B164) 2007; 13 Lee (B89) 2018; 16 Touzeau (B154) 2018; 32
References_xml	– volume: 114327 year: 2022 ident: B47 article-title: Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells publication-title: Eur J Medicinal Chem doi: 10.1016/j.ejmech.2022.114327 – volume: 22 start-page: 1 year: 2021 ident: B77 article-title: Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer publication-title: Oncol Lett doi: 10.3892/ol.2021.13072 – volume: 9 start-page: 47 year: 2008 ident: B9 article-title: The BCL-2 protein family: opposing activities that mediate cell death publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2308 – volume: 120 year: 1994 ident: B30 article-title: Bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria publication-title: Development doi: 10.1242/dev.120.10.3033 – volume: 22 start-page: 10442 year: 2021 ident: B150 article-title: B cell lymphoma 2: a potential therapeutic target for cancer therapy publication-title: Int J Mol Sci doi: 10.3390/ijms221910442 – volume: 27 start-page: 647 year: 2020 ident: B43 article-title: Identification of a covalent molecular inhibitor of anti-apoptotic BFL-1 by disulfide tethering publication-title: Cell Chem Biol doi: 10.1016/j.chembiol.2020.04.004 – volume: 21 start-page: 3385 year: 2020 ident: B135 article-title: Akkermansia muciniphila aspartic protease amuc_1434* inhibits human colorectal cancer LS174T cell viability via TRAIL-mediated apoptosis pathway publication-title: Int J Mol Sci doi: 10.3390/ijms21093385 – volume: 102 year: 2000 ident: B33 article-title: Bcl-xl protein is beneficial to the survival of cardiac myocytes publication-title: Bcl-xl Protein prolonging survival time transplanted cardiac myocytes by reducing release mitochondrial cytochrome C prolonging Cold storage time cardiac myocytes doi: 10.1016/s0092-8674(00)00080-5 – volume: 5 year: 2000 ident: B132 article-title: Role of reactive oxygen species (ROS) in apoptosis induction publication-title: Apoptosis doi: 10.1023/a:1009616228304 – volume: 22 year: 2021 ident: B45 article-title: Selective covalent targeting of anti-apoptotic BFL-1 by a sulfonium-tethered peptide publication-title: ChemBioChem doi: 10.1002/cbic.202000473 – volume: 44 start-page: 517e531 year: 2011 ident: B147 article-title: A unifified model of mammalian BCL-2 protein family interactions at the mitochondria, mol publication-title: Cell doi: 10.1016/j.molcel.2011.10.001 – volume: 177 start-page: 63 year: 2019 ident: B163 article-title: The chemical biology of apoptosis: revisited after 17 years publication-title: Eur J Medicinal Chem doi: 10.1016/j.ejmech.2019.05.019 – volume: 9 start-page: 1 year: 2018 ident: B50 article-title: Bax retrotranslocation potentiates bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance publication-title: Cell Death Dis doi: 10.1038/s41419-018-0464-6 – volume: 41 year: 2022 ident: B122 article-title: The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner publication-title: Oncogene doi: 10.1038/s41388-021-02161-1 – volume: 157 year: 2000 ident: B81 article-title: The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64557-9 – volume: 136 start-page: 12 year: 2017 ident: B160 article-title: Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2017.03.006 – volume: 10 start-page: 1638 year: 2020 ident: B69 article-title: The mysteries around the BCL-2 family member BOK publication-title: Biomolecules doi: 10.3390/biom10121638 – volume: 7 start-page: 1 year: 2021 ident: B96 article-title: BH3-only proteins puma and Beclin1 regulate autophagic death in neurons in response to amyloid-β publication-title: Cell Death Discovery doi: 10.1038/s41420-021-00748-x – volume: 17 year: 1998 ident: B37 article-title: Bim: a novel member of the BCL-2 family that promotes apoptosis publication-title: EMBO J doi: 10.1093/emboj/17.2.384 – volume: 32 year: 2013 ident: B40 article-title: MicroRNA-125b promotes apoptosis by regulating the expression of mcl-1, bcl-w and IL-6R publication-title: Oncogene doi: 10.1038/onc.2012.318 – volume: 548 start-page: 39 year: 2021 ident: B97 article-title: Structural basis of the p53 DNA binding domain and PUMA complex publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2021.02.049 – volume: 8 year: 2019 ident: B82 article-title: Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both bcl-XL and BCL-2 publication-title: Elife doi: 10.7554/eLife.37689 – volume: 13 start-page: 1374 year: 2021 ident: B145 article-title: Structural investigation of orf virus BCL-2 homolog orfv125 interactions with BH3-motifs from BH3-only proteins puma and hrk publication-title: Viruses doi: 10.3390/v13071374 – volume: 47 year: 2020 ident: B42 article-title: Methanolic extract of artemisia absinthium prompts apoptosis, enhancing expression of Bax/BCL-2 ratio, cell cycle arrest, caspase-3 activation and mitochondrial membrane potential destruction in human colorectal cancer HCT-116 cells publication-title: Mol Biol Rep doi: 10.1007/s11033-020-05933-2 – volume: 39 year: 2007 ident: B133 article-title: Reactive oxygen species in mitochondria-mediated cell death publication-title: Drug Metab Rev doi: 10.1080/03602530701468516 – volume: 1833 year: 2013 ident: B2 article-title: Crosstalk between apoptosis, necrosis and autophagy publication-title: Biochim Biophys Acta (BBA)-Molecular Cell Res doi: 10.1016/j.bbamcr.2013.06.001 – volume: 148 year: 1996 ident: B111 article-title: Prognostic significance of BCL-2 in clinically localized prostate cancer publication-title: Am J Pathol – volume: 18 start-page: 1414e1424 year: 2011 ident: B146 article-title: The role of BCL-2 and its pro-survival relatives in tumourigenesis and cancer therapy publication-title: Cell Death Differ doi: 10.1038/cdd.2011.17 – volume: 1 start-page: 4 year: 2021 ident: B101 article-title: Morphological features of tumor in different treatment options for patients with locally advanced breast cancer publication-title: Int J Innovative Analyses Emerging Technol – volume: 33 year: 2019 ident: B139 article-title: Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis publication-title: FASEB J doi: 10.1096/fj.201801417R – volume: 26 year: 2019 ident: B67 article-title: Bok regulates mitochondrial fusion and morphology publication-title: Cell Death Differ doi: 10.1038/s41418-019-0327-4 – volume: 9 year: 2020 ident: B59 article-title: The third model of Bax/Bak activation: a BCL-2 family feud finally resolved publication-title: F1000Research doi: 10.12688/f1000research.25607.1 – volume: 26 year: 2007 ident: B35 article-title: A novel BCL-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma publication-title: Oncogene doi: 10.1038/sj.onc.1210028 – volume: 1366 year: 1998 ident: B129 article-title: The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy publication-title: Biochim Biophys Acta doi: 10.1016/s0005-2728(98)00112-1 – volume: 24 start-page: 75 year: 2014 ident: B134 article-title: Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia–reperfusion injury publication-title: Trends Cardiovasc Med doi: 10.1016/j.tcm.2013.06.007 – volume: 39 year: 2020 ident: B31 article-title: The apoptosis inhibitor bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production publication-title: Oncogene doi: 10.1038/s41388-020-1212-9 – volume: 534 year: 2021 ident: B54 article-title: Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2020.12.019 – volume: 81 year: 2021 ident: B131 article-title: Redox metabolism: ROS as specific molecular regulators of cell signaling and function publication-title: Mol Cell doi: 10.1016/j.molcel.2021.08.018 – volume: 80 year: 2020 ident: B76 article-title: Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase substrate to suppress tumor proliferation publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-1555 – volume: 103 start-page: 1256 year: 2018 ident: B106 article-title: Hide or defend, the two strategies of lymphoma immune evasion: potential implications for immunotherapy publication-title: Haematologica doi: 10.3324/haematol.2017.184192 – volume: 7 year: 2001 ident: B91 article-title: PUMA, a novel proapoptotic gene, is induced by p53 publication-title: Mol Cell doi: 10.1016/S1097-2765(01)00214-3 – volume: 137 start-page: 137:3 year: 2018 ident: B115 article-title: BCL-2Antiapoptotic family proteins and chemoresistance in cancer publication-title: Adv Cancer Res doi: 10.1016/bs.acr.2017.11.001 – volume: 89 start-page: 289 year: 2015 ident: B28 article-title: The mystery of BCL-2 family: BCL-2 proteins and apoptosis: an update publication-title: Arch Toxicol doi: 10.1007/s00204-014-1448-7 – volume: 353 year: 2020 ident: B158 article-title: A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate publication-title: Int Rev Cell Mol Biol doi: 10.1016/bs.ircmb.2019.12.005 – volume: 24 start-page: 3896 year: 2019 ident: B44 article-title: Exploring the conformational space of BCL-2 protein variants: dynamic contributions of the flexible loop domain and transmembrane region publication-title: Molecules doi: 10.3390/molecules24213896 – volume: 2012 year: 2012 ident: B27 article-title: Dentatin induces apoptosis in prostate cancer cells via BCL-2, bcl-xL, survivin downregulation, caspase-9,-3/7 activation, and NF-κB inhibition publication-title: Evidence-Based Complementary Altern Med doi: 10.1155/2012/856029 – year: 2018 ident: B107 article-title: The role of DNA replication fork remodeling proteins in lymphomagenesis and hematopoietic cell replication stress publication-title: (Doctoral dissertation) – volume: 126 start-page: 110040 year: 2020 ident: B79 article-title: Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin publication-title: Biomedicine Pharmacotherapy doi: 10.1016/j.biopha.2020.110040 – volume: 234 year: 2019 ident: B119 article-title: Bile salt (glycochenodeoxycholate acid) induces cell survival and chemoresistance in hepatocellular carcinoma publication-title: J Cell Physiol doi: 10.1002/jcp.27905 – volume: 16 start-page: 12 year: 2021 ident: B26 article-title: Oxidative stress battles neuronal bcl-xL in a fight to the death publication-title: Neural Regeneration Res doi: 10.4103/1673-5374.286946 – volume: 500 start-page: 26 year: 2018 ident: B51 article-title: BCL-2 proteins and apoptosis: Recent insights and unknowns publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2017.06.190 – volume: 19 year: 2007 ident: B98 article-title: BCL-2-regulated apoptosis: mechanism and therapeutic potential publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2007.05.004 – volume: 9 start-page: 1 year: 2018 ident: B65 article-title: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer publication-title: Cell Death Dis doi: 10.1038/s41419-017-0140-2 – volume: 94 year: 1997 ident: B66 article-title: Bok is a pro-apoptotic BCL-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic BCL-2 family members publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.23.12401 – volume: 10 year: 2004 ident: B130 article-title: Oxygen, reactive oxygen species and tissue damage publication-title: Curr Pharm Des doi: 10.2174/1381612043384664 – volume: 28 year: 2021 ident: B85 article-title: Phosphorylation by aurora b kinase regulates caspase-2 activity and function publication-title: Cell Death Differentiation doi: 10.1038/s41418-020-00604-y – volume: 26 year: 2019 ident: B88 article-title: BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL publication-title: Cell Death Differ doi: 10.1038/s41418-018-0183-7 – volume: 43 start-page: 573e585 year: 2011 ident: B46 article-title: Bflfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2010.12.014 – volume: 15 year: 2009 ident: B10 article-title: Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-08-0144 – volume: 11 start-page: 222 year: 2021 ident: B95 article-title: Selective autophagy of intracellular organelles: Recent research advances publication-title: Theranostics doi: 10.7150/thno.49860 – volume: 234 year: 2019 ident: B121 article-title: The novel non-immunological role and underlying mechanisms of B7-H3 in tumorigenesis publication-title: J Cell Physiol doi: 10.1002/jcp.28936 – volume: 12 year: 2012 ident: B149 article-title: Combining immunotherapy and targeted therapies in cancer treatment publication-title: Nat Rev Cancer doi: 10.1038/nrc3237 – volume: 8 year: 2009 ident: B167 article-title: Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-09-0493 – volume: 27 start-page: 536 year: 2022 ident: B157 article-title: Small drugs, huge impact: The extraordinary impact of antisense oligonucleotides in research and drug development publication-title: Molecules doi: 10.3390/molecules27020536 – volume: 35 year: 2016 ident: B103 article-title: Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breastc ancer publication-title: Oncogene doi: 10.1038/onc.2015.287 – volume: 62 year: 2018 ident: B24 article-title: Mitochondrial dynamics: overview of molecular mechanisms publication-title: Essays Biochem doi: 10.1042/EBC20170104 – volume: 65 year: 2005 ident: B18 article-title: BCL-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-4570 – volume: 14 start-page: 922 year: 2022 ident: B57 article-title: Infectious spleen and kidney necrosis virus (ISKNV) triggers mitochondria-mediated dynamic interaction signals via an imbalance of Bax/Bak over BCL-2/Bcl-xL in fish cells publication-title: Viruses doi: 10.3390/v14050922 – volume: 14 start-page: e7974 year: 2018 ident: B14 article-title: Systematic characterization of pan-cancer mutation clusters publication-title: Mol Syst Biol doi: 10.15252/msb.20177974 – volume: 10 start-page: 792 year: 2018 ident: B75 article-title: Balancing apoptosis and autophagy for parkinson’s disease therapy: targeting BCL-2 publication-title: ACS Chem Neurosci doi: 10.1021/acschemneuro.8b00356 – volume: 17 start-page: : 26 year: 2015 ident: B104 article-title: Combined histone deacetylase inhibition and tamoxi fen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing BCL-2 overexpr ession publication-title: Breast Cancer Res doi: 10.1186/s13058-015-0533-z – volume: 285 year: 2018 ident: B56 article-title: Bax, bak and beyond–mitochondrial performance in apoptosis publication-title: FEBS J doi: 10.1111/febs.14186 – volume: 25 year: 2018 ident: B108 article-title: DNA Damage pathways and b-cell lymphomagenesis publication-title: Curr Opin Hematol doi: 10.1097/MOH.0000000000000433 – volume: 2 start-page: 1 year: 2003 ident: B64 article-title: Apoptosis: targets in pancreatic cancer publication-title: Mol Cancer doi: 10.1186/1476-4598-2-6 – volume: 235 year: 2020 ident: B84 article-title: miR-125b lowers sensitivity to apoptosis following mitotic arrest: Implications for breast cancer therapy publication-title: J Cell Physiol doi: 10.1002/jcp.29610 – volume: 283 year: 2016 ident: B5 article-title: The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane publication-title: FEBS J doi: 10.1111/febs.13624 – volume: 12 year: 2022 ident: B124 article-title: Bax/BCL-2 cascade is regulated by the EGFR pathway: Therapeutic targeting of non-small cell lung cancer publication-title: Front Oncol doi: 10.3389/fonc.2022.869672 – volume: 17 start-page: 395 year: 2020 ident: B4 article-title: Targeting apoptosis in cancer therapy publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-020-0341-y – volume: 12 start-page: 256 year: 2022 ident: B70 article-title: BH3-only proteins noxa and puma are key regulators of induced apoptosis publication-title: Life doi: 10.3390/life12020256 – volume: 8 year: 2001 ident: B39 article-title: Tissue expression and subcellular localization of the pro-survival molecule bcl-w publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4400835 – volume: 16 start-page: e0259447 year: 2021 ident: B102 article-title: The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma publication-title: PloS One doi: 10.1371/journal.pone.0259447 – volume: 21 start-page: 799 year: 2020 ident: B92 article-title: Role of BCL-2 family proteins in apoptosis and its regulation by nutrients publication-title: Curr Protein Pept Sci doi: 10.2174/1389203721666191227122252 – volume: 23 year: 2009 ident: B137 article-title: Life and death by death receptors publication-title: FASEB J doi: 10.1096/fj.08-111005 – volume: 1644 start-page: 83 year: 2004 ident: B20 article-title: Structural biology of the bcl-2 family of proteins publication-title: Biochim Biophys Acta (BBA)-Molecular Cell Res doi: 10.1016/j.bbamcr.2003.08.012 – volume: 20 start-page: 1 year: 2020 ident: B93 article-title: A novel BCL-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway publication-title: BMC Cancer doi: 10.1186/s12885-019-6169-0 – volume: 236 start-page: 95 year: 2010 ident: B128 article-title: The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2010.00919.x – volume: 59 start-page: 292 year: 2015 ident: B140 article-title: Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis publication-title: J Pineal Res doi: 10.1111/jpi.12264 – volume: 61 start-page: 43 year: 2013 ident: B127 article-title: Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer publication-title: Arch Immunol Ther Exp (Warsz) doi: 10.1007/s00005-012-0205-y – volume: 119 year: 2010 ident: B166 article-title: Small inhibitor of BCL-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating BCL-2 family members in MDA-MB-231 breast cancer cells publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-009-0343-z – volume: 17 start-page: 1 year: 2017 ident: B16 article-title: Potential mechanisms of resistance to venetoclax and strategies to circumvent it publication-title: BMC Cancer doi: 10.1186/s12885-017-3383-5 – volume: 12 year: 2006 ident: B12 article-title: Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-06-0147 – volume: 2 start-page: 7 year: 2016 ident: B23 article-title: BCL2 family, mitochondrial apoptosis, and beyond publication-title: Cancer Trans Med doi: 10.4103/2395-3977.177558 – volume: 14 year: 2000 ident: B63 article-title: Role of bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins publication-title: Genes Dev doi: 10.1101/gad.182100 – volume: 523 start-page: 39 year: 2020 ident: B71 article-title: RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2019.11.185 – volume: 78 year: 2000 ident: B86 article-title: Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes publication-title: J Mol Med doi: 10.1007/s001090000099 – volume: 9 year: 2019 ident: B17 article-title: Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic LeukemiaBCL2 Gly101Val causes resistance to venetoclax in CLL publication-title: Cancer Discovery doi: 10.1158/2159-8290.CD-18-1119 – volume: 13 year: 1996 ident: B34 article-title: Bcl-w,a novel member of the BCL-2 family, prom otes cell survival publication-title: Oncogene – volume: 9 start-page: 1 year: 2019 ident: B78 article-title: Expression of the BAD pathway is a marker of triple-negative status and poor outcome publication-title: Sci Rep doi: 10.1038/s41598-019-53695-0 – volume: 148 year: 2000 ident: B25 article-title: Reduced loading of intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in BCL-2–overexpressing cells publication-title: J Cell Biol doi: 10.1083/jcb.148.5.857 – volume: 500 year: 2013 ident: B13 article-title: Signatures of mutational processes in human cancer publication-title: Nature doi: 10.1038/nature12477 – volume: 12 year: 2007 ident: B49 article-title: Bax activation and mitochondrial insertion during apoptosis publication-title: Apoptosis doi: 10.1007/s10495-007-0749-1 – volume: 79 start-page: 68 year: 2020 ident: B52 article-title: Homogeneous oligomers of pro-apoptotic BAX reveal structural determinants of mitochondrial membrane permeabilization publication-title: Mol Cell doi: 10.1016/j.molcel.2020.05.029 – volume: 76 start-page: 109772 year: 2020 ident: B58 article-title: Cell death signalling in virus infection publication-title: Cell Signalling doi: 10.1016/j.cellsig.2020.109772 – volume: 18 start-page: 1 year: 2018 ident: B114 article-title: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight publication-title: Cancer Cell Int doi: 10.1186/s12935-018-0538-7 – volume: 13 year: 2007 ident: B164 article-title: The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-07-2184 – volume: 58 year: 2017 ident: B8 article-title: Pathways and mechanisms of venetoclax resistance publication-title: Leukemia lymphoma doi: 10.1080/10428194.2017.1283032 – volume: 31 year: 2000 ident: B136 article-title: Apoptosis induced by death receptors publication-title: Pharmacochemistry library doi: 10.1016/S0165-7208(00)80030-6 – volume: 56 year: 2015 ident: B156 article-title: A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated b-cell chronic lymphocytic leukemia publication-title: Leukemia Lymphoma doi: 10.3109/10428194.2015.1030638 – volume: 25 start-page: 56 year: 2018 ident: B74 article-title: Why do BCL-2 inhibitors work and where should we use them in the clinic publication-title: Cell Death Differ doi: 10.1038/cdd.2017.183 – volume: 60 year: 2000 ident: B62 article-title: Mutations of the bak gene in human gastric and colorectal cancers publication-title: Cancer Res – volume: 12 year: 2005 ident: B73 article-title: Bak but not bax is essential for bcl-xS-induced apoptosis publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401638 – volume: 7 year: 2001 ident: B100 article-title: Function of apoptosis and expression of the proteins BCL-2, p53 and c-myc in the development of gastric cancer publication-title: World J Gastroenterol doi: 10.3748/wjg.v7.i3.403 – volume: 16 start-page: 935 year: 2020 ident: B110 article-title: MicroRNA-148b enhances the radiosensitivity of b-cell lymphoma cells by targeting bcl-w to promote apoptosis publication-title: Int J Biol Sci doi: 10.7150/ijbs.40756 – volume: 11 start-page: 211 year: 2018 ident: B116 article-title: RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and BCL-2 expression publication-title: OncoTargets Ther doi: 10.2147/OTT.S152818 – volume: 11 start-page: 727 year: 2020 ident: B83 article-title: MAGE-a inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1 publication-title: Oncotarget doi: 10.18632/oncotarget.27488 – volume: 58 year: 2004 ident: B125 article-title: Mechanisch induzierte apoptose und nekrose in alveolären typ-II-Zellen - beeinflussung durch captopril und l-arginin [Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type-II-cells–influence of captopril and l-arginine] publication-title: Pneumologie doi: 10.1055/s-2004-818408 – volume: 6 year: 2021 ident: B152 article-title: Designing BH3-mimetic peptide inhibitors for the viral BCL-2 homologues A179L and BHRF1: Importance of long-range electrostatic interactions publication-title: ACS Omega doi: 10.1021/acsomega.1c03385 – volume: 428 year: 1996 ident: B99 article-title: Apoptosis in humangastric mucosa, chronic gastritis, dysplasia, and carinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling publication-title: Virchows Arch doi: 10.1007/BF00196695 – volume: 11 year: 2022 ident: B155 article-title: Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro publication-title: Emerging Microbes Infect doi: 10.1080/22221751.2022.2026739 – volume: 121 start-page: 104660 year: 2021 ident: B6 article-title: The cell theory and cellular pathology: Discovery, refinements and applications fundamental to advances in biology and medicine publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2021.104660 – volume: 26 year: 2019 ident: B68 article-title: Bok regulates mitochondrial fusion and morphology publication-title: Cell Death Differentiation doi: 10.1038/s41418-019-0327-4 – volume: 8 start-page: 8 year: 2019 ident: B159 article-title: Venetoclax: evidence to date and clinical potential publication-title: Drugs Context doi: 10.7573/dic.212574 – volume: 38 year: 2020 ident: B161 article-title: The pan-BCL-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells publication-title: Invest N Drugs doi: 10.1007/s10637-020-00931-4 – volume: 28 year: 2021 ident: B90 article-title: Stepwise activation of the pro-apoptotic protein bid at mitochondrial membranes publication-title: Cell Death Differ doi: 10.1038/s41418-020-00716-5 – volume: 10 year: 2018 ident: B141 article-title: Anti-cancer natural products and their bioactive compounds inducing ER stress-mediated apoptosis: A review publication-title: Nutrients doi: 10.3390/nu10081021 – volume: 16 year: 2004 ident: B48 article-title: The first α helix of bax plays a necessary role in its ligand-induced activation by the BH3-only proteins bid and PUMA publication-title: Mol Cell doi: 10.1016/j.molcel.2004.10.028 – volume: 9 start-page: 1 year: 2019 ident: B138 article-title: Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer publication-title: Cell Bioscience doi: 10.1186/s13578-019-0289-8 – volume: 17 year: 2020 ident: B113 article-title: Tumour evolution in hepatocellular carcinoma publication-title: Nat Rev Gastroenterol Hep atol doi: 10.1038/s41575-019-0229-4 – volume: 29 start-page: 1 year: 2021 ident: B148 article-title: The role of ubiquitination in apoptosis and necroptosis publication-title: Cell Death Differentiation doi: 10.1038/s41418-021-00922-9 – volume: 406 start-page: 99 year: 1996 ident: B19 article-title: Structure–function analysis of bcl-2 family proteins publication-title: Mech lymphocyte activation Immune Regul VI doi: 10.1007/978-1-4899-0274-0_10 – volume: 20 year: 2019 ident: B29 article-title: The structural biology of bcl-xL publication-title: Int J Mol Sci doi: 10.3390/ijms20092234 – volume: 30 year: 2003 ident: B153 article-title: Targeting BCL-2 and bcl-XL with nonpeptidic small-molecule antagonists[C]//Seminars in oncology publication-title: WB Saunders doi: 10.1053/j.seminoncol.2003.08.015 – volume: 4 start-page: 75 year: 2018 ident: B87 article-title: Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives publication-title: J Clin Trans Res doi: 10.18053/jctres.04.201801.005 – volume: 152 start-page: 745 year: 2017 ident: B112 article-title: Liver cancer cell of origin, molecular class, and effects on patient prognosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.11.048 – volume: 38 year: 2017 ident: B21 article-title: Non-canonical roles of bcl-2 and bcl-xL proteins: relevance of BH4 domain publication-title: Carcinogenesis doi: 10.1093/carcin/bgx016 – start-page: 1 year: 2021 ident: B151 article-title: The BCL-2 silencing with an antisense oligonucleotide publication-title: Increase Early Apoptosis doi: 10.21203/rs.3.rs-936588/v1 – volume: 194 start-page: 39 year: 2011 ident: B55 article-title: Transient binding of an activator BH3 domain to the bak BH3-binding groove initiates bak oligomerization publication-title: J Cell Biol doi: 10.1083/jcb.201102027 – volume: 1813 year: 2011 ident: B80 article-title: Molecular biology of bax and bak activation and action publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2010.12.019 – volume: 32 year: 2018 ident: B154 article-title: Targeting bcl-2 for the treatment of multiple myeloma publication-title: Leukemia doi: 10.1038/s41375-018-0223-9 – volume: 8 year: 2019 ident: B109 article-title: Targeting the BCL-2 family in b cell lymphoma publication-title: Front Oncol doi: 10.3389/fonc.2018.00636 – volume: 41 start-page: 11 year: 2008 ident: B142 article-title: The role of mitochondria in apoptosis publication-title: BMB Rep doi: 10.5483/bmbrep.2008.41.1.011 – volume: 51 year: 2019 ident: B117 article-title: miRNA-448 inhibits cell growth by targeting BCL-2 in hepatocellular carcinoma publication-title: Digestive Liver Dis doi: 10.1016/j.dld.2018.09.021 – volume: 22 year: 2020 ident: B120 article-title: Identifying lung cancer risk factors in the elderly using deep neural networks: quantitative analysis of web-based survey data publication-title: J Med Internet Res doi: 10.2196/17695 – volume: 39 year: 2020 ident: B61 article-title: Pore formation in regulated cell death publication-title: EMBO J doi: 10.15252/embj.2020105753 – volume: 132 year: 2018 ident: B7 article-title: The rise of apoptosis: targeting apoptosis in hematologic malignancies publication-title: Blood doi: 10.1182/blood-2018-02-791350 – volume: 20 year: 2019 ident: B1 article-title: Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-018-0089-8 – volume: 228 year: 1985 ident: B144 article-title: Involvement of the BCL-2 gene in human follicular lymphoma publication-title: Science doi: 10.1126/science.3874430 – volume: 195 start-page: 13 year: 2019 ident: B41 article-title: Targeting mcl-1 and other BCL-2 family member proteins in cancer therapy publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2018.10.009 – volume: 86 year: 1995 ident: B11 article-title: Expression of bcl-xL can confer a multidrug resistance phenotype publication-title: Blood doi: 10.1182/blood.V86.5.1903.bloodjournal8651903 – volume: 3 start-page: 71 year: 2018 ident: B53 article-title: BH3-dependent and independent activation of BAX and BAK in mitochondrial apoptosis publication-title: Curr Opin Physiol doi: 10.1016/j.cophys.2018.03.005 – volume: 32 year: 2002 ident: B36 article-title: The anti-apoptotic molecules bcl-xL and bcl-w target protein phosphatase 1α to bad publication-title: Eur J Immunol doi: 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 – volume: 123 year: 2014 ident: B15 article-title: Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma publication-title: Blood J Am Soc Hematol doi: 10.1182/blood-2014-03-560284 – volume: 26 year: 2021 ident: B94 article-title: The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases publication-title: Apoptosis doi: 10.1007/s10495-021-01667-z – volume: 73 start-page: 2013 year: 1993 ident: B143 article-title: Apoptosis publication-title: Cancer doi: 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J – volume: 10 year: 2000 ident: B118 article-title: Expression of BCL-2 inhibited fas-mediated apoptosis in human hepatocellular carcinoma BEL7404 cells publication-title: Cell Res doi: 10.1038/sj.cr.7290052 – volume: 11 start-page: 1 year: 2020 ident: B32 article-title: BCL-w: apoptotic and non-apoptotic role in health and disease publication-title: Cell Death Dis doi: 10.1038/s41419-020-2417-0 – volume: 25 year: 2020 ident: B38 article-title: Myeloid cell leukemin-1 inhibitors: A growing arsenal for cancer therapy publication-title: Drug Discov Today doi: 10.1016/j.drudis.2020.07.021 – volume: 10 start-page: 1 year: 2020 ident: B165 article-title: TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer publication-title: Sci Rep doi: 10.1038/s41598-020-70636-4 – volume: 276 year: 2001 ident: B72 article-title: Cytochrome c depletion upon expression of bcl-XS publication-title: J Biol Chem doi: 10.1074/jbc.M008171200 – volume: 480 year: 2000 ident: B60 article-title: Evolutionarily conserved bok proteins in the BCL-2 family publication-title: FEBS Lett doi: 10.1016/S0014-5793(00)01921-9 – volume: 16 year: 2018 ident: B89 article-title: Ferroptosis-induced endoplasmic reticulum stress: cross-talk between ferroptosis and apoptosis publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-18-0055 – volume: 8 start-page: 180002 year: 2018 ident: B3 article-title: Targeting BCL-2 regulated apoptosis in cancer publication-title: Open Biol doi: 10.1098/rsob.180002 – volume: 78 year: 2021 ident: B22 article-title: Mitochondrial outer membrane permeabilization at the single molecule level publication-title: Cell Mol Life Sci doi: 10.1007/s00018-021-03771-4 – volume: 30 start-page: 95 year: 2021 ident: B105 publication-title: ‘ doi: 10.3233/CBM-201497 – volume: 110 year: 2012 ident: B126 article-title: Regulation of the inflammatory response in cardiac repair publication-title: Circ Res doi: 10.1161/CIRCRESAHA.111.243162 – volume: 19 year: 2013 ident: B162 article-title: ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets publication-title: Nat Med doi: 10.1038/nm.3048 – volume: 89 start-page: 55 year: 2003 ident: B123 article-title: Role of BCL-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis publication-title: Br J Cancer doi: 10.1038/sj.bjc.6601095
SSID	ssj0000650103
Score	2.706024
SecondaryResourceType	review_article
Snippet	Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the...
SourceID	doaj pubmedcentral proquest crossref
SourceType	Open Website Open Access Repository Aggregation Database Enrichment Source Index Database
StartPage	985363
SubjectTerms	apoptosis autoimmunity Bcl-2 cancer Oncology systematic
Title	The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
URI	https://www.proquest.com/docview/2730645592 https://pubmed.ncbi.nlm.nih.gov/PMC9597512 https://doaj.org/article/68892708f91c4ce5a51031b41c504970
Volume	12
WOSCitedRecordID	wos000876910600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagQogL4imWR2UkLhzMbvxI7COtWnHYVhwA7c2ynbGIhJzVZovEpb-9njitNhe4cMkhsRX7m4lnJh5_Q8gHrVrBQXBWSyeYFN4wFyKwVdQgWy4gjqfSfqyby0u92ZivB6W-MCes0AMX4Ja11oY3Kx1NFWQA5ZACrvKyCio7t80YrWev5yCYKmuwwgIGZV8yR2FmGfuEjIWcfzLZQtViZodGuv6ZjznPkDwwOedPyOPJV6SfyxifknuQnpGHF9Nu-HOyzjKmmB5I-0hPTteM0_K_go7sC10aaJforlSbzyaKum2_3fdDN1CXWhpQ4DtaTmD9eUG-n599O_3CpuoILM9c7ZnRK-e99iDzQoF2RnEJSMdXad-oqvGhVc7UXIZY--zXgGhAB66hNcZ748VLcpT6BK8I9dKLCGElQoxSRnCq9jp3cOAN1G27IMtbrGyYqMOxgsUvm0MIRNciuhbRtQXdBfl412NbaDP-0vYE4b9rh4TX442sBnZSA_svNViQ97fCs_kDwV0Pl6C_Gmz2z5CTTxm-IM1MqrM3zp-k7udItW1yvJVdotf_Y4hvyCOcNRvTYd6So_3uCt6RB-H3vht2x-R-s9HHoxbn68X12Q1qDPaI
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+role+of+BCL-2+family+proteins+in+regulating+apoptosis+and+cancer+therapy&rft.jtitle=Frontiers+in+oncology&rft.au=Qian%2C+Shanna&rft.au=Wei%2C+Zhong&rft.au=Yang%2C+Wanting&rft.au=Huang%2C+Jinling&rft.date=2022-10-12&rft.pub=Frontiers+Media+S.A&rft.eissn=2234-943X&rft.volume=12&rft_id=info:doi/10.3389%2Ffonc.2022.985363&rft.externalDocID=PMC9597512
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon