The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family ha...

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Vydáno v:	Frontiers in oncology Ročník 12; s. 985363
Hlavní autoři:	Qian, Shanna, Wei, Zhong, Yang, Wanting, Huang, Jinling, Yang, Yinfeng, Wang, Jinghui
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Frontiers Media S.A 12.10.2022
Témata:	apoptosis autoimmunity Bcl-2 cancer Oncology systematic
ISSN:	2234-943X, 2234-943X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.
AbstractList	Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer. Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies. Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy. Since the inflammatory response induced by apoptosis-induced cell death is very small, at present, the development of anticancer drugs targeting apoptosis has attracted more and more attention. Consequently, the focus of this review is to summarize the current research on the role of BCL-2 family proteins in regulating apoptosis and the development of drugs targeting BCL-2 anti-apoptotic proteins. Additionally, the mechanism of BCL-2 family proteins in regulating apoptosis was also explored. All the findings indicate the potential of BCL-2 family proteins in the therapy of cancer.
Author	Wei, Zhong Yang, Wanting Huang, Jinling Wang, Jinghui Qian, Shanna Yang, Yinfeng
AuthorAffiliation	1 School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine , Hefei , China 3 School of Medical Informatics Engineering, Anhui University of Chinese Medicine , Hefei , China 2 Gastrointestinal Surgery, Anhui Provincial Hospital , Hefei , China
AuthorAffiliation_xml	– name: 1 School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine , Hefei , China – name: 3 School of Medical Informatics Engineering, Anhui University of Chinese Medicine , Hefei , China – name: 2 Gastrointestinal Surgery, Anhui Provincial Hospital , Hefei , China
Author_xml	– sequence: 1 givenname: Shanna surname: Qian fullname: Qian, Shanna – sequence: 2 givenname: Zhong surname: Wei fullname: Wei, Zhong – sequence: 3 givenname: Wanting surname: Yang fullname: Yang, Wanting – sequence: 4 givenname: Jinling surname: Huang fullname: Huang, Jinling – sequence: 5 givenname: Yinfeng surname: Yang fullname: Yang, Yinfeng – sequence: 6 givenname: Jinghui surname: Wang fullname: Wang, Jinghui
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Cites_doi	10.1016/j.ejmech.2022.114327 10.3892/ol.2021.13072 10.1038/nrm2308 10.1242/dev.120.10.3033 10.3390/ijms221910442 10.1016/j.chembiol.2020.04.004 10.3390/ijms21093385 10.1016/s0092-8674(00)00080-5 10.1023/a:1009616228304 10.1002/cbic.202000473 10.1016/j.molcel.2011.10.001 10.1016/j.ejmech.2019.05.019 10.1038/s41419-018-0464-6 10.1038/s41388-021-02161-1 10.1016/S0002-9440(10)64557-9 10.1016/j.bcp.2017.03.006 10.3390/biom10121638 10.1038/s41420-021-00748-x 10.1093/emboj/17.2.384 10.1038/onc.2012.318 10.1016/j.bbrc.2021.02.049 10.7554/eLife.37689 10.3390/v13071374 10.1007/s11033-020-05933-2 10.1080/03602530701468516 10.1016/j.bbamcr.2013.06.001 10.1038/cdd.2011.17 10.1096/fj.201801417R 10.1038/s41418-019-0327-4 10.12688/f1000research.25607.1 10.1038/sj.onc.1210028 10.1016/s0005-2728(98)00112-1 10.1016/j.tcm.2013.06.007 10.1038/s41388-020-1212-9 10.1016/j.bbrc.2020.12.019 10.1016/j.molcel.2021.08.018 10.1158/0008-5472.CAN-19-1555 10.3324/haematol.2017.184192 10.1016/S1097-2765(01)00214-3 10.1016/bs.acr.2017.11.001 10.1007/s00204-014-1448-7 10.1016/bs.ircmb.2019.12.005 10.3390/molecules24213896 10.1155/2012/856029 10.1016/j.biopha.2020.110040 10.1002/jcp.27905 10.4103/1673-5374.286946 10.1016/j.bbrc.2017.06.190 10.1016/j.coi.2007.05.004 10.1038/s41419-017-0140-2 10.1073/pnas.94.23.12401 10.2174/1381612043384664 10.1038/s41418-020-00604-y 10.1038/s41418-018-0183-7 10.1016/j.biocel.2010.12.014 10.1158/1078-0432.CCR-08-0144 10.7150/thno.49860 10.1002/jcp.28936 10.1038/nrc3237 10.1158/1535-7163.MCT-09-0493 10.3390/molecules27020536 10.1038/onc.2015.287 10.1042/EBC20170104 10.1158/0008-5472.CAN-04-4570 10.3390/v14050922 10.15252/msb.20177974 10.1021/acschemneuro.8b00356 10.1186/s13058-015-0533-z 10.1111/febs.14186 10.1097/MOH.0000000000000433 10.1186/1476-4598-2-6 10.1002/jcp.29610 10.1111/febs.13624 10.3389/fonc.2022.869672 10.1038/s41571-020-0341-y 10.3390/life12020256 10.1038/sj.cdd.4400835 10.1371/journal.pone.0259447 10.2174/1389203721666191227122252 10.1096/fj.08-111005 10.1016/j.bbamcr.2003.08.012 10.1186/s12885-019-6169-0 10.1111/j.1600-065X.2010.00919.x 10.1111/jpi.12264 10.1007/s00005-012-0205-y 10.1007/s10549-009-0343-z 10.1186/s12885-017-3383-5 10.1158/1078-0432.CCR-06-0147 10.4103/2395-3977.177558 10.1101/gad.182100 10.1016/j.bbrc.2019.11.185 10.1007/s001090000099 10.1158/2159-8290.CD-18-1119 10.1038/s41598-019-53695-0 10.1083/jcb.148.5.857 10.1038/nature12477 10.1007/s10495-007-0749-1 10.1016/j.molcel.2020.05.029 10.1016/j.cellsig.2020.109772 10.1186/s12935-018-0538-7 10.1158/1078-0432.CCR-07-2184 10.1080/10428194.2017.1283032 10.1016/S0165-7208(00)80030-6 10.3109/10428194.2015.1030638 10.1038/cdd.2017.183 10.1038/sj.cdd.4401638 10.3748/wjg.v7.i3.403 10.7150/ijbs.40756 10.2147/OTT.S152818 10.18632/oncotarget.27488 10.1055/s-2004-818408 10.1021/acsomega.1c03385 10.1007/BF00196695 10.1080/22221751.2022.2026739 10.1016/j.yexmp.2021.104660 10.7573/dic.212574 10.1007/s10637-020-00931-4 10.1038/s41418-020-00716-5 10.3390/nu10081021 10.1016/j.molcel.2004.10.028 10.1186/s13578-019-0289-8 10.1038/s41575-019-0229-4 10.1038/s41418-021-00922-9 10.1007/978-1-4899-0274-0_10 10.3390/ijms20092234 10.1053/j.seminoncol.2003.08.015 10.18053/jctres.04.201801.005 10.1053/j.gastro.2016.11.048 10.1093/carcin/bgx016 10.21203/rs.3.rs-936588/v1 10.1083/jcb.201102027 10.1016/j.bbamcr.2010.12.019 10.1038/s41375-018-0223-9 10.3389/fonc.2018.00636 10.5483/bmbrep.2008.41.1.011 10.1016/j.dld.2018.09.021 10.2196/17695 10.15252/embj.2020105753 10.1182/blood-2018-02-791350 10.1038/s41580-018-0089-8 10.1126/science.3874430 10.1016/j.pharmthera.2018.10.009 10.1182/blood.V86.5.1903.bloodjournal8651903 10.1016/j.cophys.2018.03.005 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 10.1182/blood-2014-03-560284 10.1007/s10495-021-01667-z 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J 10.1038/sj.cr.7290052 10.1038/s41419-020-2417-0 10.1016/j.drudis.2020.07.021 10.1038/s41598-020-70636-4 10.1074/jbc.M008171200 10.1016/S0014-5793(00)01921-9 10.1158/1541-7786.MCR-18-0055 10.1098/rsob.180002 10.1007/s00018-021-03771-4 10.3233/CBM-201497 10.1161/CIRCRESAHA.111.243162 10.1038/nm.3048 10.1038/sj.bjc.6601095
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Copyright	Copyright © 2022 Qian, Wei, Yang, Huang, Yang and Wang. Copyright © 2022 Qian, Wei, Yang, Huang, Yang and Wang 2022 Qian, Wei, Yang, Huang, Yang and Wang
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Gavin P. McStay, Liverpool John Moores University, United Kingdom Reviewed by: Jiann-Ruey Hong, National Cheng Kung University, Taiwan; Dharmendra Kumar Yadav, Gachon University, South Korea; Manzar Alam, University of Texas Southwestern Medical Center, United States This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology
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Publisher	Frontiers Media S.A
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References	Roufayel (B70) 2022; 12 Janaghard (B151) 2021 Buja (B6) 2021; 121 Chang (B118) 2000; 10 Arbab (B27) 2012; 2012 Opydo-Chanek (B161) 2020; 38 Alexandrov (B13) 2013; 500 Chen (B57) 2022; 14 Dai (B55) 2011; 194 Varela (B165) 2020; 10 Maji (B115) 2018; 137 Luna-Vargas (B5) 2016; 283 Puccetti (B107) 2018 Zhou (B121) 2019; 234 Yang (B163) 2019; 177 Han (B97) 2021; 548 Sun (B102) 2021; 16 Matthew-Onabanjo (B76) 2020; 80 Hung (B90) 2021; 28 Hsu (B66) 1997; 94 Ishida (B99) 1996; 428 Roberts (B148) 2021; 29 Pinton (B25) 2000; 148 Guicciardi (B137) 2009; 23 Peña-Blanco (B56) 2018; 285 Martin (B123) 2003; 89 Simon (B132) 2000; 5 Luo (B59) 2020; 9 Arisan (B166) 2010; 119 Campbell (B3) 2018; 8 Schneider (B136) 2000; 31 Buljan (B14) 2018; 14 Knittel (B108) 2018; 25 Ramachandran (B87) 2018; 4 Kipps (B156) 2015; 56 Gong (B40) 2013; 32 Zhu (B38) 2020; 25 Bose (B8) 2017; 58 Hauseman (B52) 2020; 79 Lee (B29) 2019; 20 Fridman (B72) 2001; 276 Tahir (B16) 2017; 17 Bergamini (B130) 2004; 10 de Charette (B106) 2018; 103 Kelly (B146) 2011; 18 Youle (B9) 2008; 9 Adams (B98) 2007; 19 Rasmussen (B158) 2020; 353 Li (B95) 2021; 11 Alam (B124) 2022; 12 Jeong (B142) 2008; 41 Sirotković-Skerlev (B105) 2021; 30 Wang (B153) 2003; 30 Craig (B113) 2020; 17 Yin (B86) 2000; 78 Hoppe (B33) 2000; 102 Mei (B83) 2020; 11 Matuszyk (B84) 2020; 235 Carneiro (B4) 2020; 17 Vanneman (B149) 2012; 12 Liu (B45) 2021; 22 Zhang (B71) 2020; 523 Choi (B18) 2005; 65 Ayllón (B36) 2002; 32 Sun (B93) 2020; 20 Lindenboim (B73) 2005; 12 Xu (B100) 2001; 7 Merino (B103) 2016; 35 Wang (B119) 2019; 234 Saha (B96) 2021; 7 Opydo-Chanek (B160) 2017; 136 Petros (B20) 2004; 1644 Flores-Romero (B61) 2020; 39 Jeng (B53) 2018; 3 Gabellini (B21) 2017; 38 Schulman (B68) 2019; 26 Jackson (B63) 2000; 14 Singh (B1) 2019; 20 Tsujimoto (B144) 1985; 228 Zheng (B92) 2020; 21 Kerr (B143) 1993; 73 Bessou (B31) 2020; 39 Chaabane (B127) 2013; 61 Nazeri (B42) 2020; 47 Kalpage (B139) 2019; 33 Mao (B155) 2022; 11 Xia (B138) 2019; 9 Park (B26) 2021; 16 Valentin (B7) 2018; 132 Llambi (B147) 2011; 44 Chauhan (B35) 2007; 26 Montero (B74) 2018; 25 Walsh (B128) 2010; 236 González-García (B30) 1994; 120 Li (B94) 2021; 26 Suraweera (B145) 2021; 13 Reed (B19) 1996; 406 Lee (B54) 2021; 534 Liu (B75) 2018; 10 Liu (B82) 2019; 8 Schulman (B67) 2019; 26 Reilly (B39) 2001; 8 Lohitesh (B114) 2018; 18 Westphal (B64) 2003; 2 Caro-Gómez (B44) 2019; 24 Boac (B78) 2019; 9 Meng (B135) 2020; 21 Yoshioka (B134) 2014; 24 Liao (B117) 2019; 51 Quemener (B157) 2022; 27 Hartman (B32) 2020; 11 Imre (B58) 2020; 76 Frangogiannis (B126) 2012; 110 Kang (B10) 2009; 15 Gibson (B34) 1996; 13 Yamaguchi (B41) 2019; 195 Lennicke (B131) 2021; 81 O’Reilly (B81) 2000; 157 Kim (B141) 2018; 10 Hantusch (B50) 2018; 9 Sia (B112) 2017; 152 Chen (B120) 2020; 22 Alam (B150) 2021; 22 Blombery (B17) 2019; 9 Luo (B77) 2021; 22 Meinhardt (B122) 2022; 41 Westphal (B80) 2011; 1813 Nikoletopoulou (B2) 2013; 1833 O’Connor (B37) 1998; 17 Fresquet (B15) 2014; 123 Cartron (B48) 2004; 16 Kondo (B62) 2000; 60 Juárez-Salcedo (B159) 2019; 8 Raha (B104) 2015; 17 Wu (B79) 2020; 126 Dai (B23) 2016; 2 Ilkhomovna (B101) 2021; 1 Harvey (B43) 2020; 27 Dadsena (B22) 2021; 78 Edlich (B51) 2018; 500 Lim (B85) 2021; 28 Tilokani (B24) 2018; 62 Reddy (B152) 2021; 6 Lemasters (B129) 1998; 1366 Hammerschmidt (B125) 2004; 58 Siddiqui (B28) 2015; 89 Shalaby (B69) 2020; 10 Nakano (B91) 2001; 7 Liu (B116) 2018; 11 Simonin (B167) 2009; 8 Kathania (B46) 2011; 43 Minn (B11) 1995; 86 Fernández (B140) 2015; 59 Lalier (B49) 2007; 12 Zhang (B60) 2000; 480 Bubendorf (B111) 1996; 148 Souers (B162) 2013; 19 Yoshino (B12) 2006; 12 Liu (B110) 2020; 16 Feng (B47) 2022; 114327 Carberry (B65) 2018; 9 Orrenius (B133) 2007; 39 Adams (B109) 2019; 8 Greaves (B88) 2019; 26 Verdine (B164) 2007; 13 Lee (B89) 2018; 16 Touzeau (B154) 2018; 32
References_xml	– volume: 114327 year: 2022 ident: B47 article-title: Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells publication-title: Eur J Medicinal Chem doi: 10.1016/j.ejmech.2022.114327 – volume: 22 start-page: 1 year: 2021 ident: B77 article-title: Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer publication-title: Oncol Lett doi: 10.3892/ol.2021.13072 – volume: 9 start-page: 47 year: 2008 ident: B9 article-title: The BCL-2 protein family: opposing activities that mediate cell death publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2308 – volume: 120 year: 1994 ident: B30 article-title: Bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria publication-title: Development doi: 10.1242/dev.120.10.3033 – volume: 22 start-page: 10442 year: 2021 ident: B150 article-title: B cell lymphoma 2: a potential therapeutic target for cancer therapy publication-title: Int J Mol Sci doi: 10.3390/ijms221910442 – volume: 27 start-page: 647 year: 2020 ident: B43 article-title: Identification of a covalent molecular inhibitor of anti-apoptotic BFL-1 by disulfide tethering publication-title: Cell Chem Biol doi: 10.1016/j.chembiol.2020.04.004 – volume: 21 start-page: 3385 year: 2020 ident: B135 article-title: Akkermansia muciniphila aspartic protease amuc_1434* inhibits human colorectal cancer LS174T cell viability via TRAIL-mediated apoptosis pathway publication-title: Int J Mol Sci doi: 10.3390/ijms21093385 – volume: 102 year: 2000 ident: B33 article-title: Bcl-xl protein is beneficial to the survival of cardiac myocytes publication-title: Bcl-xl Protein prolonging survival time transplanted cardiac myocytes by reducing release mitochondrial cytochrome C prolonging Cold storage time cardiac myocytes doi: 10.1016/s0092-8674(00)00080-5 – volume: 5 year: 2000 ident: B132 article-title: Role of reactive oxygen species (ROS) in apoptosis induction publication-title: Apoptosis doi: 10.1023/a:1009616228304 – volume: 22 year: 2021 ident: B45 article-title: Selective covalent targeting of anti-apoptotic BFL-1 by a sulfonium-tethered peptide publication-title: ChemBioChem doi: 10.1002/cbic.202000473 – volume: 44 start-page: 517e531 year: 2011 ident: B147 article-title: A unifified model of mammalian BCL-2 protein family interactions at the mitochondria, mol publication-title: Cell doi: 10.1016/j.molcel.2011.10.001 – volume: 177 start-page: 63 year: 2019 ident: B163 article-title: The chemical biology of apoptosis: revisited after 17 years publication-title: Eur J Medicinal Chem doi: 10.1016/j.ejmech.2019.05.019 – volume: 9 start-page: 1 year: 2018 ident: B50 article-title: Bax retrotranslocation potentiates bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance publication-title: Cell Death Dis doi: 10.1038/s41419-018-0464-6 – volume: 41 year: 2022 ident: B122 article-title: The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner publication-title: Oncogene doi: 10.1038/s41388-021-02161-1 – volume: 157 year: 2000 ident: B81 article-title: The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64557-9 – volume: 136 start-page: 12 year: 2017 ident: B160 article-title: Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2017.03.006 – volume: 10 start-page: 1638 year: 2020 ident: B69 article-title: The mysteries around the BCL-2 family member BOK publication-title: Biomolecules doi: 10.3390/biom10121638 – volume: 7 start-page: 1 year: 2021 ident: B96 article-title: BH3-only proteins puma and Beclin1 regulate autophagic death in neurons in response to amyloid-β publication-title: Cell Death Discovery doi: 10.1038/s41420-021-00748-x – volume: 17 year: 1998 ident: B37 article-title: Bim: a novel member of the BCL-2 family that promotes apoptosis publication-title: EMBO J doi: 10.1093/emboj/17.2.384 – volume: 32 year: 2013 ident: B40 article-title: MicroRNA-125b promotes apoptosis by regulating the expression of mcl-1, bcl-w and IL-6R publication-title: Oncogene doi: 10.1038/onc.2012.318 – volume: 548 start-page: 39 year: 2021 ident: B97 article-title: Structural basis of the p53 DNA binding domain and PUMA complex publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2021.02.049 – volume: 8 year: 2019 ident: B82 article-title: Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both bcl-XL and BCL-2 publication-title: Elife doi: 10.7554/eLife.37689 – volume: 13 start-page: 1374 year: 2021 ident: B145 article-title: Structural investigation of orf virus BCL-2 homolog orfv125 interactions with BH3-motifs from BH3-only proteins puma and hrk publication-title: Viruses doi: 10.3390/v13071374 – volume: 47 year: 2020 ident: B42 article-title: Methanolic extract of artemisia absinthium prompts apoptosis, enhancing expression of Bax/BCL-2 ratio, cell cycle arrest, caspase-3 activation and mitochondrial membrane potential destruction in human colorectal cancer HCT-116 cells publication-title: Mol Biol Rep doi: 10.1007/s11033-020-05933-2 – volume: 39 year: 2007 ident: B133 article-title: Reactive oxygen species in mitochondria-mediated cell death publication-title: Drug Metab Rev doi: 10.1080/03602530701468516 – volume: 1833 year: 2013 ident: B2 article-title: Crosstalk between apoptosis, necrosis and autophagy publication-title: Biochim Biophys Acta (BBA)-Molecular Cell Res doi: 10.1016/j.bbamcr.2013.06.001 – volume: 148 year: 1996 ident: B111 article-title: Prognostic significance of BCL-2 in clinically localized prostate cancer publication-title: Am J Pathol – volume: 18 start-page: 1414e1424 year: 2011 ident: B146 article-title: The role of BCL-2 and its pro-survival relatives in tumourigenesis and cancer therapy publication-title: Cell Death Differ doi: 10.1038/cdd.2011.17 – volume: 1 start-page: 4 year: 2021 ident: B101 article-title: Morphological features of tumor in different treatment options for patients with locally advanced breast cancer publication-title: Int J Innovative Analyses Emerging Technol – volume: 33 year: 2019 ident: B139 article-title: Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis publication-title: FASEB J doi: 10.1096/fj.201801417R – volume: 26 year: 2019 ident: B67 article-title: Bok regulates mitochondrial fusion and morphology publication-title: Cell Death Differ doi: 10.1038/s41418-019-0327-4 – volume: 9 year: 2020 ident: B59 article-title: The third model of Bax/Bak activation: a BCL-2 family feud finally resolved publication-title: F1000Research doi: 10.12688/f1000research.25607.1 – volume: 26 year: 2007 ident: B35 article-title: A novel BCL-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma publication-title: Oncogene doi: 10.1038/sj.onc.1210028 – volume: 1366 year: 1998 ident: B129 article-title: The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy publication-title: Biochim Biophys Acta doi: 10.1016/s0005-2728(98)00112-1 – volume: 24 start-page: 75 year: 2014 ident: B134 article-title: Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia–reperfusion injury publication-title: Trends Cardiovasc Med doi: 10.1016/j.tcm.2013.06.007 – volume: 39 year: 2020 ident: B31 article-title: The apoptosis inhibitor bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production publication-title: Oncogene doi: 10.1038/s41388-020-1212-9 – volume: 534 year: 2021 ident: B54 article-title: Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2020.12.019 – volume: 81 year: 2021 ident: B131 article-title: Redox metabolism: ROS as specific molecular regulators of cell signaling and function publication-title: Mol Cell doi: 10.1016/j.molcel.2021.08.018 – volume: 80 year: 2020 ident: B76 article-title: Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase substrate to suppress tumor proliferation publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-1555 – volume: 103 start-page: 1256 year: 2018 ident: B106 article-title: Hide or defend, the two strategies of lymphoma immune evasion: potential implications for immunotherapy publication-title: Haematologica doi: 10.3324/haematol.2017.184192 – volume: 7 year: 2001 ident: B91 article-title: PUMA, a novel proapoptotic gene, is induced by p53 publication-title: Mol Cell doi: 10.1016/S1097-2765(01)00214-3 – volume: 137 start-page: 137:3 year: 2018 ident: B115 article-title: BCL-2Antiapoptotic family proteins and chemoresistance in cancer publication-title: Adv Cancer Res doi: 10.1016/bs.acr.2017.11.001 – volume: 89 start-page: 289 year: 2015 ident: B28 article-title: The mystery of BCL-2 family: BCL-2 proteins and apoptosis: an update publication-title: Arch Toxicol doi: 10.1007/s00204-014-1448-7 – volume: 353 year: 2020 ident: B158 article-title: A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate publication-title: Int Rev Cell Mol Biol doi: 10.1016/bs.ircmb.2019.12.005 – volume: 24 start-page: 3896 year: 2019 ident: B44 article-title: Exploring the conformational space of BCL-2 protein variants: dynamic contributions of the flexible loop domain and transmembrane region publication-title: Molecules doi: 10.3390/molecules24213896 – volume: 2012 year: 2012 ident: B27 article-title: Dentatin induces apoptosis in prostate cancer cells via BCL-2, bcl-xL, survivin downregulation, caspase-9,-3/7 activation, and NF-κB inhibition publication-title: Evidence-Based Complementary Altern Med doi: 10.1155/2012/856029 – year: 2018 ident: B107 article-title: The role of DNA replication fork remodeling proteins in lymphomagenesis and hematopoietic cell replication stress publication-title: (Doctoral dissertation) – volume: 126 start-page: 110040 year: 2020 ident: B79 article-title: Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin publication-title: Biomedicine Pharmacotherapy doi: 10.1016/j.biopha.2020.110040 – volume: 234 year: 2019 ident: B119 article-title: Bile salt (glycochenodeoxycholate acid) induces cell survival and chemoresistance in hepatocellular carcinoma publication-title: J Cell Physiol doi: 10.1002/jcp.27905 – volume: 16 start-page: 12 year: 2021 ident: B26 article-title: Oxidative stress battles neuronal bcl-xL in a fight to the death publication-title: Neural Regeneration Res doi: 10.4103/1673-5374.286946 – volume: 500 start-page: 26 year: 2018 ident: B51 article-title: BCL-2 proteins and apoptosis: Recent insights and unknowns publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2017.06.190 – volume: 19 year: 2007 ident: B98 article-title: BCL-2-regulated apoptosis: mechanism and therapeutic potential publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2007.05.004 – volume: 9 start-page: 1 year: 2018 ident: B65 article-title: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer publication-title: Cell Death Dis doi: 10.1038/s41419-017-0140-2 – volume: 94 year: 1997 ident: B66 article-title: Bok is a pro-apoptotic BCL-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic BCL-2 family members publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.23.12401 – volume: 10 year: 2004 ident: B130 article-title: Oxygen, reactive oxygen species and tissue damage publication-title: Curr Pharm Des doi: 10.2174/1381612043384664 – volume: 28 year: 2021 ident: B85 article-title: Phosphorylation by aurora b kinase regulates caspase-2 activity and function publication-title: Cell Death Differentiation doi: 10.1038/s41418-020-00604-y – volume: 26 year: 2019 ident: B88 article-title: BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL publication-title: Cell Death Differ doi: 10.1038/s41418-018-0183-7 – volume: 43 start-page: 573e585 year: 2011 ident: B46 article-title: Bflfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2010.12.014 – volume: 15 year: 2009 ident: B10 article-title: Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-08-0144 – volume: 11 start-page: 222 year: 2021 ident: B95 article-title: Selective autophagy of intracellular organelles: Recent research advances publication-title: Theranostics doi: 10.7150/thno.49860 – volume: 234 year: 2019 ident: B121 article-title: The novel non-immunological role and underlying mechanisms of B7-H3 in tumorigenesis publication-title: J Cell Physiol doi: 10.1002/jcp.28936 – volume: 12 year: 2012 ident: B149 article-title: Combining immunotherapy and targeted therapies in cancer treatment publication-title: Nat Rev Cancer doi: 10.1038/nrc3237 – volume: 8 year: 2009 ident: B167 article-title: Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-09-0493 – volume: 27 start-page: 536 year: 2022 ident: B157 article-title: Small drugs, huge impact: The extraordinary impact of antisense oligonucleotides in research and drug development publication-title: Molecules doi: 10.3390/molecules27020536 – volume: 35 year: 2016 ident: B103 article-title: Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breastc ancer publication-title: Oncogene doi: 10.1038/onc.2015.287 – volume: 62 year: 2018 ident: B24 article-title: Mitochondrial dynamics: overview of molecular mechanisms publication-title: Essays Biochem doi: 10.1042/EBC20170104 – volume: 65 year: 2005 ident: B18 article-title: BCL-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-4570 – volume: 14 start-page: 922 year: 2022 ident: B57 article-title: Infectious spleen and kidney necrosis virus (ISKNV) triggers mitochondria-mediated dynamic interaction signals via an imbalance of Bax/Bak over BCL-2/Bcl-xL in fish cells publication-title: Viruses doi: 10.3390/v14050922 – volume: 14 start-page: e7974 year: 2018 ident: B14 article-title: Systematic characterization of pan-cancer mutation clusters publication-title: Mol Syst Biol doi: 10.15252/msb.20177974 – volume: 10 start-page: 792 year: 2018 ident: B75 article-title: Balancing apoptosis and autophagy for parkinson’s disease therapy: targeting BCL-2 publication-title: ACS Chem Neurosci doi: 10.1021/acschemneuro.8b00356 – volume: 17 start-page: : 26 year: 2015 ident: B104 article-title: Combined histone deacetylase inhibition and tamoxi fen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing BCL-2 overexpr ession publication-title: Breast Cancer Res doi: 10.1186/s13058-015-0533-z – volume: 285 year: 2018 ident: B56 article-title: Bax, bak and beyond–mitochondrial performance in apoptosis publication-title: FEBS J doi: 10.1111/febs.14186 – volume: 25 year: 2018 ident: B108 article-title: DNA Damage pathways and b-cell lymphomagenesis publication-title: Curr Opin Hematol doi: 10.1097/MOH.0000000000000433 – volume: 2 start-page: 1 year: 2003 ident: B64 article-title: Apoptosis: targets in pancreatic cancer publication-title: Mol Cancer doi: 10.1186/1476-4598-2-6 – volume: 235 year: 2020 ident: B84 article-title: miR-125b lowers sensitivity to apoptosis following mitotic arrest: Implications for breast cancer therapy publication-title: J Cell Physiol doi: 10.1002/jcp.29610 – volume: 283 year: 2016 ident: B5 article-title: The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane publication-title: FEBS J doi: 10.1111/febs.13624 – volume: 12 year: 2022 ident: B124 article-title: Bax/BCL-2 cascade is regulated by the EGFR pathway: Therapeutic targeting of non-small cell lung cancer publication-title: Front Oncol doi: 10.3389/fonc.2022.869672 – volume: 17 start-page: 395 year: 2020 ident: B4 article-title: Targeting apoptosis in cancer therapy publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-020-0341-y – volume: 12 start-page: 256 year: 2022 ident: B70 article-title: BH3-only proteins noxa and puma are key regulators of induced apoptosis publication-title: Life doi: 10.3390/life12020256 – volume: 8 year: 2001 ident: B39 article-title: Tissue expression and subcellular localization of the pro-survival molecule bcl-w publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4400835 – volume: 16 start-page: e0259447 year: 2021 ident: B102 article-title: The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma publication-title: PloS One doi: 10.1371/journal.pone.0259447 – volume: 21 start-page: 799 year: 2020 ident: B92 article-title: Role of BCL-2 family proteins in apoptosis and its regulation by nutrients publication-title: Curr Protein Pept Sci doi: 10.2174/1389203721666191227122252 – volume: 23 year: 2009 ident: B137 article-title: Life and death by death receptors publication-title: FASEB J doi: 10.1096/fj.08-111005 – volume: 1644 start-page: 83 year: 2004 ident: B20 article-title: Structural biology of the bcl-2 family of proteins publication-title: Biochim Biophys Acta (BBA)-Molecular Cell Res doi: 10.1016/j.bbamcr.2003.08.012 – volume: 20 start-page: 1 year: 2020 ident: B93 article-title: A novel BCL-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway publication-title: BMC Cancer doi: 10.1186/s12885-019-6169-0 – volume: 236 start-page: 95 year: 2010 ident: B128 article-title: The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2010.00919.x – volume: 59 start-page: 292 year: 2015 ident: B140 article-title: Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis publication-title: J Pineal Res doi: 10.1111/jpi.12264 – volume: 61 start-page: 43 year: 2013 ident: B127 article-title: Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer publication-title: Arch Immunol Ther Exp (Warsz) doi: 10.1007/s00005-012-0205-y – volume: 119 year: 2010 ident: B166 article-title: Small inhibitor of BCL-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating BCL-2 family members in MDA-MB-231 breast cancer cells publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-009-0343-z – volume: 17 start-page: 1 year: 2017 ident: B16 article-title: Potential mechanisms of resistance to venetoclax and strategies to circumvent it publication-title: BMC Cancer doi: 10.1186/s12885-017-3383-5 – volume: 12 year: 2006 ident: B12 article-title: Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-06-0147 – volume: 2 start-page: 7 year: 2016 ident: B23 article-title: BCL2 family, mitochondrial apoptosis, and beyond publication-title: Cancer Trans Med doi: 10.4103/2395-3977.177558 – volume: 14 year: 2000 ident: B63 article-title: Role of bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins publication-title: Genes Dev doi: 10.1101/gad.182100 – volume: 523 start-page: 39 year: 2020 ident: B71 article-title: RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2019.11.185 – volume: 78 year: 2000 ident: B86 article-title: Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes publication-title: J Mol Med doi: 10.1007/s001090000099 – volume: 9 year: 2019 ident: B17 article-title: Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic LeukemiaBCL2 Gly101Val causes resistance to venetoclax in CLL publication-title: Cancer Discovery doi: 10.1158/2159-8290.CD-18-1119 – volume: 13 year: 1996 ident: B34 article-title: Bcl-w,a novel member of the BCL-2 family, prom otes cell survival publication-title: Oncogene – volume: 9 start-page: 1 year: 2019 ident: B78 article-title: Expression of the BAD pathway is a marker of triple-negative status and poor outcome publication-title: Sci Rep doi: 10.1038/s41598-019-53695-0 – volume: 148 year: 2000 ident: B25 article-title: Reduced loading of intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in BCL-2–overexpressing cells publication-title: J Cell Biol doi: 10.1083/jcb.148.5.857 – volume: 500 year: 2013 ident: B13 article-title: Signatures of mutational processes in human cancer publication-title: Nature doi: 10.1038/nature12477 – volume: 12 year: 2007 ident: B49 article-title: Bax activation and mitochondrial insertion during apoptosis publication-title: Apoptosis doi: 10.1007/s10495-007-0749-1 – volume: 79 start-page: 68 year: 2020 ident: B52 article-title: Homogeneous oligomers of pro-apoptotic BAX reveal structural determinants of mitochondrial membrane permeabilization publication-title: Mol Cell doi: 10.1016/j.molcel.2020.05.029 – volume: 76 start-page: 109772 year: 2020 ident: B58 article-title: Cell death signalling in virus infection publication-title: Cell Signalling doi: 10.1016/j.cellsig.2020.109772 – volume: 18 start-page: 1 year: 2018 ident: B114 article-title: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight publication-title: Cancer Cell Int doi: 10.1186/s12935-018-0538-7 – volume: 13 year: 2007 ident: B164 article-title: The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-07-2184 – volume: 58 year: 2017 ident: B8 article-title: Pathways and mechanisms of venetoclax resistance publication-title: Leukemia lymphoma doi: 10.1080/10428194.2017.1283032 – volume: 31 year: 2000 ident: B136 article-title: Apoptosis induced by death receptors publication-title: Pharmacochemistry library doi: 10.1016/S0165-7208(00)80030-6 – volume: 56 year: 2015 ident: B156 article-title: A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated b-cell chronic lymphocytic leukemia publication-title: Leukemia Lymphoma doi: 10.3109/10428194.2015.1030638 – volume: 25 start-page: 56 year: 2018 ident: B74 article-title: Why do BCL-2 inhibitors work and where should we use them in the clinic publication-title: Cell Death Differ doi: 10.1038/cdd.2017.183 – volume: 60 year: 2000 ident: B62 article-title: Mutations of the bak gene in human gastric and colorectal cancers publication-title: Cancer Res – volume: 12 year: 2005 ident: B73 article-title: Bak but not bax is essential for bcl-xS-induced apoptosis publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401638 – volume: 7 year: 2001 ident: B100 article-title: Function of apoptosis and expression of the proteins BCL-2, p53 and c-myc in the development of gastric cancer publication-title: World J Gastroenterol doi: 10.3748/wjg.v7.i3.403 – volume: 16 start-page: 935 year: 2020 ident: B110 article-title: MicroRNA-148b enhances the radiosensitivity of b-cell lymphoma cells by targeting bcl-w to promote apoptosis publication-title: Int J Biol Sci doi: 10.7150/ijbs.40756 – volume: 11 start-page: 211 year: 2018 ident: B116 article-title: RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and BCL-2 expression publication-title: OncoTargets Ther doi: 10.2147/OTT.S152818 – volume: 11 start-page: 727 year: 2020 ident: B83 article-title: MAGE-a inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1 publication-title: Oncotarget doi: 10.18632/oncotarget.27488 – volume: 58 year: 2004 ident: B125 article-title: Mechanisch induzierte apoptose und nekrose in alveolären typ-II-Zellen - beeinflussung durch captopril und l-arginin [Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type-II-cells–influence of captopril and l-arginine] publication-title: Pneumologie doi: 10.1055/s-2004-818408 – volume: 6 year: 2021 ident: B152 article-title: Designing BH3-mimetic peptide inhibitors for the viral BCL-2 homologues A179L and BHRF1: Importance of long-range electrostatic interactions publication-title: ACS Omega doi: 10.1021/acsomega.1c03385 – volume: 428 year: 1996 ident: B99 article-title: Apoptosis in humangastric mucosa, chronic gastritis, dysplasia, and carinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling publication-title: Virchows Arch doi: 10.1007/BF00196695 – volume: 11 year: 2022 ident: B155 article-title: Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro publication-title: Emerging Microbes Infect doi: 10.1080/22221751.2022.2026739 – volume: 121 start-page: 104660 year: 2021 ident: B6 article-title: The cell theory and cellular pathology: Discovery, refinements and applications fundamental to advances in biology and medicine publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2021.104660 – volume: 26 year: 2019 ident: B68 article-title: Bok regulates mitochondrial fusion and morphology publication-title: Cell Death Differentiation doi: 10.1038/s41418-019-0327-4 – volume: 8 start-page: 8 year: 2019 ident: B159 article-title: Venetoclax: evidence to date and clinical potential publication-title: Drugs Context doi: 10.7573/dic.212574 – volume: 38 year: 2020 ident: B161 article-title: The pan-BCL-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells publication-title: Invest N Drugs doi: 10.1007/s10637-020-00931-4 – volume: 28 year: 2021 ident: B90 article-title: Stepwise activation of the pro-apoptotic protein bid at mitochondrial membranes publication-title: Cell Death Differ doi: 10.1038/s41418-020-00716-5 – volume: 10 year: 2018 ident: B141 article-title: Anti-cancer natural products and their bioactive compounds inducing ER stress-mediated apoptosis: A review publication-title: Nutrients doi: 10.3390/nu10081021 – volume: 16 year: 2004 ident: B48 article-title: The first α helix of bax plays a necessary role in its ligand-induced activation by the BH3-only proteins bid and PUMA publication-title: Mol Cell doi: 10.1016/j.molcel.2004.10.028 – volume: 9 start-page: 1 year: 2019 ident: B138 article-title: Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer publication-title: Cell Bioscience doi: 10.1186/s13578-019-0289-8 – volume: 17 year: 2020 ident: B113 article-title: Tumour evolution in hepatocellular carcinoma publication-title: Nat Rev Gastroenterol Hep atol doi: 10.1038/s41575-019-0229-4 – volume: 29 start-page: 1 year: 2021 ident: B148 article-title: The role of ubiquitination in apoptosis and necroptosis publication-title: Cell Death Differentiation doi: 10.1038/s41418-021-00922-9 – volume: 406 start-page: 99 year: 1996 ident: B19 article-title: Structure–function analysis of bcl-2 family proteins publication-title: Mech lymphocyte activation Immune Regul VI doi: 10.1007/978-1-4899-0274-0_10 – volume: 20 year: 2019 ident: B29 article-title: The structural biology of bcl-xL publication-title: Int J Mol Sci doi: 10.3390/ijms20092234 – volume: 30 year: 2003 ident: B153 article-title: Targeting BCL-2 and bcl-XL with nonpeptidic small-molecule antagonists[C]//Seminars in oncology publication-title: WB Saunders doi: 10.1053/j.seminoncol.2003.08.015 – volume: 4 start-page: 75 year: 2018 ident: B87 article-title: Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives publication-title: J Clin Trans Res doi: 10.18053/jctres.04.201801.005 – volume: 152 start-page: 745 year: 2017 ident: B112 article-title: Liver cancer cell of origin, molecular class, and effects on patient prognosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.11.048 – volume: 38 year: 2017 ident: B21 article-title: Non-canonical roles of bcl-2 and bcl-xL proteins: relevance of BH4 domain publication-title: Carcinogenesis doi: 10.1093/carcin/bgx016 – start-page: 1 year: 2021 ident: B151 article-title: The BCL-2 silencing with an antisense oligonucleotide publication-title: Increase Early Apoptosis doi: 10.21203/rs.3.rs-936588/v1 – volume: 194 start-page: 39 year: 2011 ident: B55 article-title: Transient binding of an activator BH3 domain to the bak BH3-binding groove initiates bak oligomerization publication-title: J Cell Biol doi: 10.1083/jcb.201102027 – volume: 1813 year: 2011 ident: B80 article-title: Molecular biology of bax and bak activation and action publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2010.12.019 – volume: 32 year: 2018 ident: B154 article-title: Targeting bcl-2 for the treatment of multiple myeloma publication-title: Leukemia doi: 10.1038/s41375-018-0223-9 – volume: 8 year: 2019 ident: B109 article-title: Targeting the BCL-2 family in b cell lymphoma publication-title: Front Oncol doi: 10.3389/fonc.2018.00636 – volume: 41 start-page: 11 year: 2008 ident: B142 article-title: The role of mitochondria in apoptosis publication-title: BMB Rep doi: 10.5483/bmbrep.2008.41.1.011 – volume: 51 year: 2019 ident: B117 article-title: miRNA-448 inhibits cell growth by targeting BCL-2 in hepatocellular carcinoma publication-title: Digestive Liver Dis doi: 10.1016/j.dld.2018.09.021 – volume: 22 year: 2020 ident: B120 article-title: Identifying lung cancer risk factors in the elderly using deep neural networks: quantitative analysis of web-based survey data publication-title: J Med Internet Res doi: 10.2196/17695 – volume: 39 year: 2020 ident: B61 article-title: Pore formation in regulated cell death publication-title: EMBO J doi: 10.15252/embj.2020105753 – volume: 132 year: 2018 ident: B7 article-title: The rise of apoptosis: targeting apoptosis in hematologic malignancies publication-title: Blood doi: 10.1182/blood-2018-02-791350 – volume: 20 year: 2019 ident: B1 article-title: Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-018-0089-8 – volume: 228 year: 1985 ident: B144 article-title: Involvement of the BCL-2 gene in human follicular lymphoma publication-title: Science doi: 10.1126/science.3874430 – volume: 195 start-page: 13 year: 2019 ident: B41 article-title: Targeting mcl-1 and other BCL-2 family member proteins in cancer therapy publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2018.10.009 – volume: 86 year: 1995 ident: B11 article-title: Expression of bcl-xL can confer a multidrug resistance phenotype publication-title: Blood doi: 10.1182/blood.V86.5.1903.bloodjournal8651903 – volume: 3 start-page: 71 year: 2018 ident: B53 article-title: BH3-dependent and independent activation of BAX and BAK in mitochondrial apoptosis publication-title: Curr Opin Physiol doi: 10.1016/j.cophys.2018.03.005 – volume: 32 year: 2002 ident: B36 article-title: The anti-apoptotic molecules bcl-xL and bcl-w target protein phosphatase 1α to bad publication-title: Eur J Immunol doi: 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 – volume: 123 year: 2014 ident: B15 article-title: Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma publication-title: Blood J Am Soc Hematol doi: 10.1182/blood-2014-03-560284 – volume: 26 year: 2021 ident: B94 article-title: The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases publication-title: Apoptosis doi: 10.1007/s10495-021-01667-z – volume: 73 start-page: 2013 year: 1993 ident: B143 article-title: Apoptosis publication-title: Cancer doi: 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J – volume: 10 year: 2000 ident: B118 article-title: Expression of BCL-2 inhibited fas-mediated apoptosis in human hepatocellular carcinoma BEL7404 cells publication-title: Cell Res doi: 10.1038/sj.cr.7290052 – volume: 11 start-page: 1 year: 2020 ident: B32 article-title: BCL-w: apoptotic and non-apoptotic role in health and disease publication-title: Cell Death Dis doi: 10.1038/s41419-020-2417-0 – volume: 25 year: 2020 ident: B38 article-title: Myeloid cell leukemin-1 inhibitors: A growing arsenal for cancer therapy publication-title: Drug Discov Today doi: 10.1016/j.drudis.2020.07.021 – volume: 10 start-page: 1 year: 2020 ident: B165 article-title: TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer publication-title: Sci Rep doi: 10.1038/s41598-020-70636-4 – volume: 276 year: 2001 ident: B72 article-title: Cytochrome c depletion upon expression of bcl-XS publication-title: J Biol Chem doi: 10.1074/jbc.M008171200 – volume: 480 year: 2000 ident: B60 article-title: Evolutionarily conserved bok proteins in the BCL-2 family publication-title: FEBS Lett doi: 10.1016/S0014-5793(00)01921-9 – volume: 16 year: 2018 ident: B89 article-title: Ferroptosis-induced endoplasmic reticulum stress: cross-talk between ferroptosis and apoptosis publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-18-0055 – volume: 8 start-page: 180002 year: 2018 ident: B3 article-title: Targeting BCL-2 regulated apoptosis in cancer publication-title: Open Biol doi: 10.1098/rsob.180002 – volume: 78 year: 2021 ident: B22 article-title: Mitochondrial outer membrane permeabilization at the single molecule level publication-title: Cell Mol Life Sci doi: 10.1007/s00018-021-03771-4 – volume: 30 start-page: 95 year: 2021 ident: B105 publication-title: ‘ doi: 10.3233/CBM-201497 – volume: 110 year: 2012 ident: B126 article-title: Regulation of the inflammatory response in cardiac repair publication-title: Circ Res doi: 10.1161/CIRCRESAHA.111.243162 – volume: 19 year: 2013 ident: B162 article-title: ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets publication-title: Nat Med doi: 10.1038/nm.3048 – volume: 89 start-page: 55 year: 2003 ident: B123 article-title: Role of BCL-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis publication-title: Br J Cancer doi: 10.1038/sj.bjc.6601095
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Snippet	Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the...
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SubjectTerms	apoptosis autoimmunity Bcl-2 cancer Oncology systematic
Title	The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
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