Prevalence and course of depression in older people with aortic stenosis undergoing transcatheter aortic valve implantation – a systematic review and meta-analysis

Background Depression is the most prevalent psychiatric disorder in older people with cardiovascular disease and an independent risk factor for cardiac surgery outcomes. Given the rising number of older people with aortic stenosis in need of transcatheter aortic valve implantation (TAVI) and the inc...

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Vydáno v:BMC geriatrics Ročník 25; číslo 1; s. 756 - 13
Hlavní autoři: Maschke, Verena, Mons, Ute, Lohner, Valerie
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 06.10.2025
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Aged
Aged patients
Aged, 80 and over
Aging
Analysis
Aortic stenosis
Aortic valve
Aortic valve stenosis
Aortic Valve Stenosis - diagnosis
Aortic Valve Stenosis - epidemiology
Aortic Valve Stenosis - psychology
Aortic Valve Stenosis - surgery
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Complications and side effects
Content analysis
Cross-sectional studies
Depression
Depression - diagnosis
Depression - epidemiology
Depression - psychology
Depression in old age
Depression, Mental
Ethnicity
Geriatrics/Gerontology
Gerontology
Heart surgery
Heart valve replacement
Humans
Medicine
Medicine & Public Health
Mental depression
Meta-analysis
Older people
Prevalence
Prognosis
Psychocardiology
Rehabilitation
Risk factors
Sample size
Statistics
Strategic planning (Business)
Systematic Review
Thoracic surgery
Transcatheter aortic valve replacement
Transcatheter Aortic Valve Replacement - psychology
Transcatheter Aortic Valve Replacement - trends
Germany
United States > US
Depression
Systematic review
Transcatheter aortic valve replacement
Aortic valve stenosis
Psychocardiology
Meta-analysis
ISSN:1471-2318, 1471-2318
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Shrnutí:Background Depression is the most prevalent psychiatric disorder in older people with cardiovascular disease and an independent risk factor for cardiac surgery outcomes. Given the rising number of older people with aortic stenosis in need of transcatheter aortic valve implantation (TAVI) and the increasingly recognized role of depression as a prognostic factor, this systematic review and meta-analysis aimed to derive a global estimate of the prevalence of depression and to examine its course from pre- to post-TAVI. Methods We included articles reporting prevalence of depression (diagnosed or assessed using validated instruments) or change in depressive symptoms in people undergoing TAVI. We performed three main meta-analyses: (1) prevalence of diagnosed depression, (2) prevalence of assessed depression and (3) standardized mean change (SMC) of depressive symptoms from pre- to post-TAVI. Results We included 32 studies in this systematic review, 26 of which were suitable for meta-analysis. The pooled prevalence of diagnosed and assessed depression was 6.0% [95%-Confidence interval: 3.3, 10.6] and 18.5% [13.0, 25.6], respectively. We observed a small, albeit non-significant trend towards a decrease in depressive symptoms from pre- to post-TAVI (SMC: -0.08 [-0.37, 0.22]). Conclusions A relevant proportion of people undergoing TAVI experiences depression, and the discrepancy in prevalence estimates of diagnosed and assessed depression indicates a potential under-diagnosis of depression. Disease management strategies should be adapted to include screening for and adequate treatment of depression in this population. Improvement of depressive symptoms after TAVI should not be taken for granted.
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ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-025-06402-w