Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated that newborn granule cells contribute to cognition. However, previous strat...

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Vydané v:	Learning & memory (Cold Spring Harbor, N.Y.) Ročník 16; číslo 2; s. 147
Hlavní autori:	Jessberger, Sebastian, Clark, Robert E, Broadbent, Nicola J, Clemenson, Jr, Gregory D, Consiglio, Antonella, Lie, D Chichung, Squire, Larry R, Gage, Fred H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.02.2009
Predmet:	Animals Animals, Genetically Modified Dentate Gyrus - cytology Dentate Gyrus - growth & development Dentate Gyrus - physiology Food Preferences Form Perception - physiology Genetic Vectors Lentivirus - genetics Male Maze Learning - physiology Memory - physiology Neurons - physiology Psychomotor Performance - physiology Rats Rats, Sprague-Dawley Recognition, Psychology - physiology Social Environment Space Perception - physiology Stereotaxic Techniques Wnt Proteins - genetics Wnt Proteins - physiology
ISSN:	1549-5485, 1549-5485
On-line prístup:	Zistit podrobnosti o prístupe
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