Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated that newborn granule cells contribute to cognition. However, previous strat...

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Bibliographic Details
Published in:	Learning & memory (Cold Spring Harbor, N.Y.) Vol. 16; no. 2; p. 147
Main Authors:	Jessberger, Sebastian, Clark, Robert E, Broadbent, Nicola J, Clemenson, Jr, Gregory D, Consiglio, Antonella, Lie, D Chichung, Squire, Larry R, Gage, Fred H
Format:	Journal Article
Language:	English
Published:	United States 01.02.2009
Subjects:	Animals Animals, Genetically Modified Dentate Gyrus - cytology Dentate Gyrus - growth & development Dentate Gyrus - physiology Food Preferences Form Perception - physiology Genetic Vectors Lentivirus - genetics Male Maze Learning - physiology Memory - physiology Neurons - physiology Psychomotor Performance - physiology Rats Rats, Sprague-Dawley Recognition, Psychology - physiology Social Environment Space Perception - physiology Stereotaxic Techniques Wnt Proteins - genetics Wnt Proteins - physiology
ISSN:	1549-5485, 1549-5485
Online Access:	Get more information
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