Endothelium-derived nitric oxide and vascular physiology and pathology

In 1980, Furchgott and Zawadzki demonstrated that the relaxation of vascular smooth muscle cells in response to acetylcholine is dependent on the anatomical integrity of the endothelium. Endothelium-derived relaxing factor was identified 7 years later as the free radical gas nitric oxide (NO). In en...

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Bibliographic Details
Published in:	Cellular and molecular life sciences : CMLS Vol. 55; no. 9; pp. 1078 - 1087
Main Authors:	Arnal, J.-F., Dinh-Xuan, A.-T., Pueyo, M., Darblade, B., Rami, J.
Format:	Journal Article
Language:	English
Published:	Switzerland Springer Nature B.V 01.07.1999 Birkhäuser Verlag
Subjects:	Adenosine Adenosine diphosphate Amino acids Animals Arginine Arginine - metabolism Arteriosclerosis Arteriosclerosis - physiopathology Atherosclerosis Bioavailability Blood pressure Blood Vessels - physiology Bradykinin Calcium (intracellular) Calcium ions Caveolae Caveolin 1 Caveolins Cell Adhesion Cell proliferation Citrulline Cytoskeleton Cytosol Defects Diabetes mellitus Endothelium Endothelium, Vascular - physiology Enzymatic activity Enzyme activity Enzyme Induction Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Free radicals Gene expression Humans Hypercholesterolemia Hypertension Hypertension - drug therapy Hypertension - physiopathology Hypertension, Pulmonary - physiopathology Isoenzymes - metabolism Membrane Proteins - metabolism Muscle contraction NG-Nitroarginine Methyl Ester - toxicity Nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III omega-N-Methylarginine - pharmacology omega-N-Methylarginine - therapeutic use Oxidative Stress Pathology Pathophysiology Phosphorylation Physiology Proteins Rabbits Risk factors Serotonin Shear stress Signal Transduction Smooth muscle Thrombin Translocation Vascular Diseases - physiopathology Vasodilation Vasodilation - physiology
ISSN:	1420-682X, 1420-9071
Online Access:	Get full text
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