Nutraceutical Potential of Carica papaya in Metabolic Syndrome

Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic co...

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Vydáno v:	Nutrients Ročník 11; číslo 7; s. 1608
Hlavní autoři:	Santana, Lidiani F., Inada, Aline C., Espirito Santo, Bruna Larissa Spontoni do, Filiú, Wander F. O., Pott, Arnildo, Alves, Flávio M., Guimarães, Rita de Cássia A., Freitas, Karine de Cássia, Hiane, Priscila A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 16.07.2019 MDPI
Témata:	antioxidants benzyl isothiocyanate beta-carotene beta-cryptoxanthin cardiovascular system Carica Carica papaya cholesterol diabetes mellitus Dietary Supplements flavonoids folic acid free radicals Fruit fruits glucosinolates Humans Hypoglycemia leaves linoleic acid magnesium Metabolic syndrome Metabolic Syndrome - diet therapy minerals nutrients Nutritive Value obesity oils oleic acid palmitic acid pantothenic acid Phytochemicals polyphenols potassium pulp Review saponins seeds stearic acid subtropics tocopherols vitamin A metabolic syndrome blood glucose natural products Carica papaya food composition
ISSN:	2072-6643, 2072-6643
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Abstract	Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (α and δ), β-cryptoxanthin, β-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders.
AbstractList	Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (α and δ), β-cryptoxanthin, β-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders. L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (α and δ), β-cryptoxanthin, β-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders. Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (α and δ), β-cryptoxanthin, β-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders.Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (α and δ), β-cryptoxanthin, β-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders. [...]few studies have demonstrated the therapeutic potential in metabolic dysfunctions in experimental models specific to obesity. [...]the present study will investigate the nutritional value and bioactive compounds of the plant, as well as the existing medicinal uses and possible application in the metabolic syndrome. 2. The green fruit is used in preparations, such as salads, cakes, ice creams and juice, without carotene [20], but with all of the other nutrients listed in Table 1 and Table 2. Besides the ripe papaya pulp, the consumption of other parts, such as the seeds and leaves, is appropriate, since they have a higher nutritional value and more fibers [7]. [...]the metabolic syndrome can be defined as the set of these risk factors, i.e., a cluster of metabolic disorders associated with obesity, including insulin resistance, atherogenic dyslipidemia and hypertension, which can lead to cardiovascular illnesses [45]. Since adipose tissue is a source of a great number of adipokines, such as the tumor necrosis factor (TNF-α), interleukin 6 (IL-6), monocyte chemoattractant protein, also known as chemokine ligand 2 (MCP-1/CCL-2), leptin, adiponectin, and resistin, among others [46], the larger the accumulation of adipose tissue, the higher the production of these adipokines. In relation to the metabolic dysfunctions, C. papaya displays hypoglycemic, hypolipidemic and antihypertensive potential and demonstrates increased antioxidant activity in experimental models in vivo and in vitro. [...]studies including researches on diet-induced and genetic obesity models in addition to the isolation of specific substances from different parts of C. papaya will be important for the development of novel natural products on the treatment and prevention of obesity and metabolic disturbances.
Author	Inada, Aline C. Espirito Santo, Bruna Larissa Spontoni do Freitas, Karine de Cássia Alves, Flávio M. Santana, Lidiani F. Hiane, Priscila A. Filiú, Wander F. O. Pott, Arnildo Guimarães, Rita de Cássia A.
AuthorAffiliation	3 Institute of Biosciences, Federal University of Mato Grosso do Sul-UFMS, MS 79079-900 Campo Grande, Brazil 2 Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Federal University of Mato Grosso do Sul-UFMS, MS 79079-900 Campo Grande, Brazil 1 Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, MS 79079-900 Campo Grande, Brazil
AuthorAffiliation_xml	– name: 1 Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, MS 79079-900 Campo Grande, Brazil – name: 3 Institute of Biosciences, Federal University of Mato Grosso do Sul-UFMS, MS 79079-900 Campo Grande, Brazil – name: 2 Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Federal University of Mato Grosso do Sul-UFMS, MS 79079-900 Campo Grande, Brazil
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31315213$$D View this record in MEDLINE/PubMed
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Cites_doi	10.4172/2155-6156.1000740 10.1016/j.jep.2009.11.024 10.4103/0975-9476.96519 10.1159/000442527 10.1515/jbcpp-2013-0002 10.1371/journal.pone.0049493 10.1042/cs051377s 10.1016/S0024-3205(02)01708-3 10.1016/S2222-1808(14)60617-4 10.4269/ajtmh.2001.65.304 10.1016/j.freeradbiomed.2009.04.030 10.1007/s10787-008-7008-0 10.4314/tjpr.v13i11.15 10.1016/0308-8146(86)90084-1 10.1016/S0026-0495(00)80082-7 10.1016/j.steroids.2012.12.009 10.1007/s13105-010-0056-0 10.1097/00004872-199305000-00008 10.1002/ptr.1706 10.1016/j.hermed.2013.04.004 10.1016/S0031-9422(00)90258-9 10.1590/S0101-20612012005000099 10.1016/S0378-8741(98)00015-4 10.1021/jf000891u 10.1016/j.jep.2012.11.017 10.1021/jf0627672 10.1152/ajpcell.1996.271.5.C1424 10.1016/S0031-9422(01)00077-2 10.1021/jf102576j 10.1093/jn/130.1.15 10.3390/ijerph13050446 10.1055/s-0034-1383122 10.1016/S0378-8741(02)00370-7 10.4314/tjpr.v6i1.14645 10.1016/j.mce.2015.02.018 10.9734/BJPR/2013/4517 10.1016/j.canlet.2008.05.016 10.1016/j.ecl.2013.09.009 10.1172/JCI37048 10.1248/bpb.25.1645 10.2353/ajpath.2008.080019 10.5455/jice.20160124113528 10.2337/dc12-0336 10.1016/j.bjp.2014.07.012 10.1016/j.foodchem.2012.07.023 10.3329/bjp.v5i1.5305 10.1186/1472-6882-12-236 10.3923/pjn.2005.379.381 10.1016/j.jfca.2007.03.009 10.1021/jf000892m 10.2337/diab.40.4.405 10.3390/nu10091304 10.1016/j.lwt.2015.09.008 10.18632/oncotarget.16725 10.1002/lipd.12128 10.1002/1099-1573(200006)14:4<235::AID-PTR574>3.0.CO;2-G 10.1080/14786419.2010.523703
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Copyright	2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 by the authors. 2019
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References	Baynes (ref_69) 1991; 40 Oboh (ref_66) 2014; 25 Miean (ref_25) 2001; 49 Minami (ref_82) 1993; 11 Tang (ref_13) 1971; 10 Hasimun (ref_75) 2018; 10 Rajkapoor (ref_29) 2002; 25 Gray (ref_65) 2000; 130 Nwofia (ref_7) 2012; 2 Kamer (ref_39) 2010; 22 Vij (ref_5) 2015; 5 Pajkovic (ref_14) 2008; 269 Ezekwe (ref_56) 2017; 8 Tona (ref_34) 1998; 61 Omonkhua (ref_51) 2011; 17 Ezekwe (ref_55) 2014; 2 Ching (ref_24) 2001; 49 Ando (ref_47) 2009; 47 Krishna (ref_18) 2008; 7 Kumar (ref_1) 2011; 40 Shim (ref_68) 2003; 85 ref_59 Owoyele (ref_37) 2008; 16 Pacher (ref_72) 2008; 173 Nwangwa (ref_78) 2013; 3 Matsui (ref_64) 2007; 55 Brasil (ref_79) 2014; 80 Otsuki (ref_17) 2010; 127 ref_61 Parle (ref_19) 2011; 2 Canini (ref_76) 2007; 20 Kimboguila (ref_22) 2011; 3 Bhat (ref_11) 2001; 65 Basu (ref_23) 2008; 33 Johnson (ref_53) 2015; 10 Adebiyi (ref_36) 2005; 19 Neuza (ref_26) 2009; 19 Okewumi (ref_35) 2012; 11 Quagliariello (ref_44) 2017; 8 Salla (ref_74) 2016; 66 Oloyede (ref_20) 2005; 4 Fakeye (ref_57) 2007; 6 Pandit (ref_28) 2013; 3 Kermanshai (ref_12) 2001; 57 Esposito (ref_43) 2012; 35 Anibijuwon (ref_33) 2009; 2009 Anyakudo (ref_38) 2015; 3 (ref_60) 2014; 24 Samson (ref_45) 2014; 43 Guyton (ref_80) 1981; 40 Olagunju (ref_32) 2009; 1 Sasidharan (ref_58) 2011; 25 Wilson (ref_16) 2002; 71 Awodele (ref_27) 2016; 5 Marfo (ref_8) 1986; 22 Anderson (ref_46) 2009; 119 (ref_41) 2019; 36 Maniyar (ref_54) 2012; 3 Saari (ref_2) 2012; 2012 Osunkwo (ref_87) 1987; 15 Hamden (ref_62) 2011; 67 Vuong (ref_15) 2013; 3 Liu (ref_63) 2013; 145 Ceriello (ref_70) 2000; 49 Adenowo (ref_52) 2014; 13 Leopoldini (ref_77) 2010; 58 Franquni (ref_81) 2013; 78 Balasuriya (ref_83) 2012; 135 Sadeque (ref_31) 2010; 5 Sule (ref_30) 2012; 15 Beckman (ref_71) 1996; 271 ref_86 Osunkwo (ref_88) 1994; 1 Nayak (ref_10) 2007; 45 ref_40 ref_84 ref_3 Asrih (ref_42) 2015; 418 Adefegha (ref_67) 2010; 49 Aravind (ref_9) 2013; 1 Bari (ref_21) 2006; 9 Eno (ref_85) 2000; 14 Teixeira (ref_4) 2012; 32 Ottaiano (ref_49) 2016; 90 Adeneye (ref_50) 2009; 1 (ref_73) 2003; 76 ref_6 Fouret (ref_48) 2019; 54
References_xml	– volume: 1 start-page: 7 year: 2013 ident: ref_9 article-title: Traditional and Medicinal Uses of Carica papaya publication-title: J. Med. Plants Stud. – volume: 8 start-page: 5 year: 2017 ident: ref_56 article-title: GC-MS Analysis, Hypoglycemic Activity of Aqueous Root Extract of Carica papaya and Its Effects on Blood Lipid Profile and Hepatorenal Tissues Biomarkers of Diabetic Rats publication-title: J. Diabetes Metab. doi: 10.4172/2155-6156.1000740 – volume: 127 start-page: 760 year: 2010 ident: ref_17 article-title: Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2009.11.024 – volume: 45 start-page: 739 year: 2007 ident: ref_10 article-title: Wound healing activity of Carica papaya L. in experimentally induced diabetic rats publication-title: Indian J. Exp. Biol. – volume: 3 start-page: 70 year: 2012 ident: ref_54 article-title: Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats publication-title: J. Ayurveda Integr. Med. doi: 10.4103/0975-9476.96519 – volume: 10 start-page: 317 year: 2018 ident: ref_75 article-title: Potential Role of Carica papaya Leaves in Regulating Cholesterol as Inhibitor HMG COA Reductase in the Liver on Wistar Rats Hyperlipidemia publication-title: Int. J. Pharm. Phytochem. Res. – volume: 33 start-page: 657 year: 2008 ident: ref_23 article-title: Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation publication-title: Int. J. Oncol. – volume: 90 start-page: 36 year: 2016 ident: ref_49 article-title: Diabetes and body mass index are associated with neuropathy and prognosis in colon cancer patients treated with capecitabine and oxaliplatin adjuvant chemotherapy publication-title: Oncology doi: 10.1159/000442527 – volume: 1 start-page: 11 year: 2009 ident: ref_32 article-title: Nephroprotective activities of the aqueous seed extract of Carica papaya Linn. In carbon tetrachloride induced renal injured Wistar rats: A dose-and time-dependent study publication-title: Biol. Med. – volume: 25 start-page: 21 year: 2014 ident: ref_66 article-title: Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) publication-title: J. Basic Clin. Physiol. Pharmacol. doi: 10.1515/jbcpp-2013-0002 – ident: ref_84 doi: 10.1371/journal.pone.0049493 – volume: 15 start-page: 971 year: 1987 ident: ref_87 article-title: Plasma-Catecholamine levels during development of doca, renal and spontaneous hypertension in rats publication-title: Med. Sci. Res. Biochem. – volume: 2 start-page: 109 year: 2014 ident: ref_55 article-title: Hypoglycemic, hypolipidemic and body weight effects of unripe pulp of Carica papaya using diabetic Albino rat model publication-title: J. Pharm. Phytochem. – ident: ref_86 doi: 10.1042/cs051377s – volume: 71 start-page: 497 year: 2002 ident: ref_16 article-title: Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction publication-title: Life Sci. doi: 10.1016/S0024-3205(02)01708-3 – volume: 5 start-page: 1 year: 2015 ident: ref_5 article-title: A review on medicinal properties of Carica papaya Linn publication-title: Asian Pac. J. Trop. Dis. doi: 10.1016/S2222-1808(14)60617-4 – volume: 7 start-page: 364 year: 2008 ident: ref_18 article-title: Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn.) publication-title: Nat. Prod. Radiance – volume: 65 start-page: 304 year: 2001 ident: ref_11 article-title: In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.2001.65.304 – volume: 47 start-page: 213 year: 2009 ident: ref_47 article-title: Metabolic syndrome and oxidative stress publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.04.030 – volume: 40 start-page: 2252 year: 1981 ident: ref_80 article-title: Blood pressure regulation: Basic concepts publication-title: Fed. Proc. – volume: 16 start-page: 168 year: 2008 ident: ref_37 article-title: Anti-inflammatory activities of ethanolic extract of Carica papaya leaves publication-title: Inflammopharmacology doi: 10.1007/s10787-008-7008-0 – volume: 13 start-page: 1877 year: 2014 ident: ref_52 article-title: Protective effect of ethanol leaf extract of Carica papaya Linn (Caricaceae) in alloxan-induced diabetic rats publication-title: Trop. J. Pharm. Res. doi: 10.4314/tjpr.v13i11.15 – volume: 22 start-page: 259 year: 1986 ident: ref_8 article-title: Chemical composition of papaya (Carica papaya) seeds publication-title: Food Chem. doi: 10.1016/0308-8146(86)90084-1 – volume: 3 start-page: 132 year: 2011 ident: ref_22 article-title: Extraction and characteristics of seed oil from Papaya (Carica papaya) in Congo-Brazzaville publication-title: Asian J. Agric. Sci. – volume: 49 start-page: 27 year: 2000 ident: ref_70 article-title: Oxidative stress and glycemic regulation publication-title: Metabolism doi: 10.1016/S0026-0495(00)80082-7 – volume: 11 start-page: 8612 year: 2012 ident: ref_35 article-title: Gastro-protective activity of aqueous Carica papaya seed extract on ethanol induced gastric ulcer in male rats publication-title: Afr. J. Biotechnol. – volume: 22 start-page: 27 year: 2010 ident: ref_39 article-title: Effect of ascorbic acid on incisional wound healing in streptozotocin-induced diabetic rats publication-title: Wounds – volume: 78 start-page: 379 year: 2013 ident: ref_81 article-title: Nandrolone decanoate determines cardiac remodelling and injury by an imbalance in cardiac inflammatory cytokines and ACE activity, blunting of the Bezold-Jarisch reflex, resulting in the development of hypertension publication-title: Steroids doi: 10.1016/j.steroids.2012.12.009 – volume: 67 start-page: 121 year: 2011 ident: ref_62 article-title: Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats publication-title: J. Physiol. Biochem. doi: 10.1007/s13105-010-0056-0 – volume: 11 start-page: 523 year: 1993 ident: ref_82 article-title: Relationship between cardiovascular hypertrophy and cardiac baroreflex function in spontaneously hypertensive and stroke-prone rats publication-title: J. Hypertens. doi: 10.1097/00004872-199305000-00008 – volume: 19 start-page: 628 year: 2005 ident: ref_36 article-title: Modulation of jejunal contractions by extract of Carica papaya L. seeds publication-title: Phytother. Res. doi: 10.1002/ptr.1706 – volume: 3 start-page: 104 year: 2013 ident: ref_15 article-title: Effect of extraction conditions on total phenolic compounds and antioxidant activities of Carica papaya leaf aqueous extracts publication-title: J. Herb. Med. doi: 10.1016/j.hermed.2013.04.004 – volume: 10 start-page: 117 year: 1971 ident: ref_13 article-title: Benzyl isothiocyanate of papaya fruit publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)90258-9 – volume: 32 start-page: 733 year: 2012 ident: ref_4 article-title: White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice publication-title: Food Sci. Technol. doi: 10.1590/S0101-20612012005000099 – volume: 61 start-page: 57 year: 1998 ident: ref_34 article-title: Antiamoebic and phytochemical screening of some Congolese medicinal plants publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(98)00015-4 – volume: 9 start-page: 137 year: 2006 ident: ref_21 article-title: Nutritional Analysis of two Local Varieties of Papaya (Carica papaya L.) at Different Maturation Stages publication-title: Pak. J. Biol. Sci. – volume: 49 start-page: 3101 year: 2001 ident: ref_24 article-title: Alpha-tocopherol content in 62 edible tropical plants publication-title: J. Agric. Food Chem. doi: 10.1021/jf000891u – volume: 145 start-page: 490 year: 2013 ident: ref_63 article-title: Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.11.017 – volume: 3 start-page: 47 year: 2015 ident: ref_38 article-title: Glycemic and Wound Healing Effects of Aqueous Mesocarp Extract of Unripe Carica papaya (Linn) in Diabetic and Healthy Rats publication-title: World J. Nutr. Health – volume: 55 start-page: 99 year: 2007 ident: ref_64 article-title: alpha-Glucosidase inhibitory profile of catechins and theaflavins publication-title: J. Agric. Food Chem. doi: 10.1021/jf0627672 – volume: 271 start-page: C1424 year: 1996 ident: ref_71 article-title: Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1996.271.5.C1424 – volume: 57 start-page: 427 year: 2001 ident: ref_12 article-title: Benzyl isothiocyanate is the chief or sole anthelmintic in papaya seed extracts publication-title: Phytochemistry doi: 10.1016/S0031-9422(01)00077-2 – volume: 58 start-page: 10768 year: 2010 ident: ref_77 article-title: On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme publication-title: J. Agric. Food Chem. doi: 10.1021/jf102576j – volume: 130 start-page: 15 year: 2000 ident: ref_65 article-title: The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro publication-title: J. Nutr. doi: 10.1093/jn/130.1.15 – volume: 10 start-page: 18 year: 2015 ident: ref_53 article-title: Biochemical effect of Aqueous Carica papaya Seed and Leaf Extracts on Serum Biochemistry of Alloxan Induced Diabetic Rats publication-title: IOSR J. Pharm. Biol. Sci. – ident: ref_61 doi: 10.3390/ijerph13050446 – volume: 80 start-page: 1580 year: 2014 ident: ref_79 article-title: Antihypertensive effect of Carica papaya via a reduction in ACE activity and improved baroreflex publication-title: Planta Med. doi: 10.1055/s-0034-1383122 – volume: 49 start-page: 14 year: 2010 ident: ref_67 article-title: Inhibitory effects of aqueous extract of two varieties of ginger on some key enzymes linked to type-2 diabetes in vitro publication-title: J. Food Nutr. Res. – volume: 2009 start-page: 4 year: 2009 ident: ref_33 article-title: Antimicrobial activity of Carica papaya (pawpaw leaf) on some pathogenic organisms of clinical origin from South-Western Nigeria publication-title: Ethnobot. Leafl. – volume: 85 start-page: 283 year: 2003 ident: ref_68 article-title: Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(02)00370-7 – volume: 6 start-page: 671 year: 2007 ident: ref_57 article-title: Effects of Coadministration of Extract of Carica papaya Linn (family Cariaceae) on Activity of Two Oral Hypoglycemic Agents publication-title: Trop. J. Pharm. Res. doi: 10.4314/tjpr.v6i1.14645 – volume: 418 start-page: 55 year: 2015 ident: ref_42 article-title: Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link? publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2015.02.018 – volume: 2 start-page: 6 year: 2011 ident: ref_19 article-title: Basketful benefits of papaya publication-title: Int. Res. J. Pharm. – volume: 3 start-page: 648 year: 2013 ident: ref_28 article-title: Ameliorative effect of leaves of Carica papaya in ethanol and antitubercular drug induced hepatotoxicity publication-title: Br. J. Pharm. Res. doi: 10.9734/BJPR/2013/4517 – volume: 269 start-page: 339 year: 2008 ident: ref_14 article-title: Multitargeted therapy of cancer by lycopene publication-title: Cancer Lett. doi: 10.1016/j.canlet.2008.05.016 – volume: 43 start-page: 1 year: 2014 ident: ref_45 article-title: Metabolic syndrome publication-title: Endocrinol. Metab Clin. N. Am. doi: 10.1016/j.ecl.2013.09.009 – volume: 2 start-page: 200 year: 2012 ident: ref_7 article-title: Chemical composition of leaves, fruit pulp and seeds in some Carica papaya (L) morphotypes publication-title: Int. J. Med. Aromat. Plants – ident: ref_40 – volume: 17 start-page: 241 year: 2011 ident: ref_51 article-title: Long-term hepatotoxicity and hypoglycaemic study of aqueous extracts of Carica papaya leaves on normal rabbits publication-title: Glob. J. Pure Appl. Sci. – volume: 119 start-page: 573 year: 2009 ident: ref_46 article-title: Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans publication-title: J. Clin. Investig. doi: 10.1172/JCI37048 – volume: 25 start-page: 1645 year: 2002 ident: ref_29 article-title: Effect of dried fruits of Carica papaya Linn on hepatotoxicity publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.25.1645 – volume: 173 start-page: 2 year: 2008 ident: ref_72 article-title: Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2008.080019 – volume: 5 start-page: 27 year: 2016 ident: ref_27 article-title: Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats publication-title: J. Intercult. Ethnopharmacol. doi: 10.5455/jice.20160124113528 – volume: 35 start-page: 2402 year: 2012 ident: ref_43 article-title: Metabolic syndrome and risk of cancer: A systematic review and meta-analysis publication-title: Diabetes Care doi: 10.2337/dc12-0336 – volume: 24 start-page: 341 year: 2014 ident: ref_60 article-title: Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats publication-title: Rev. Bras. Farmacogn. doi: 10.1016/j.bjp.2014.07.012 – volume: 1 start-page: 1 year: 1994 ident: ref_88 article-title: Attenuated hypothalamic secondary pressor responsiveness and the effect of gallopamil or hydrallazine in DOCA-salt and renal hypertensive rats publication-title: Niger. J. Physiol. Sci. – volume: 135 start-page: 2320 year: 2012 ident: ref_83 article-title: Antihypertensive properties of flavonoid-rich apple peel extract publication-title: Food Chem. doi: 10.1016/j.foodchem.2012.07.023 – volume: 5 start-page: 48 year: 2010 ident: ref_31 article-title: Protective effect of dried fruits of Carica papaya on hepatotoxicity in rat publication-title: Bangladesh J. Pharmacol. doi: 10.3329/bjp.v5i1.5305 – volume: 40 start-page: 5534 year: 2011 ident: ref_1 article-title: Hemolytic activity of Indian medicinal plants towards human erythrocytes: An in vitro study publication-title: Elixir Appl. Bot. – ident: ref_59 doi: 10.1186/1472-6882-12-236 – ident: ref_6 – volume: 4 start-page: 379 year: 2005 ident: ref_20 article-title: Chemical Profile of Unripe Pulp of Carica papaya publication-title: Pak. J. Nutr. doi: 10.3923/pjn.2005.379.381 – volume: 20 start-page: 584 year: 2007 ident: ref_76 article-title: Gas chromatography–mass spectrometry analysis of phenolic compounds from Carica papaya L. leaf publication-title: J. Food Compos. Anal. doi: 10.1016/j.jfca.2007.03.009 – volume: 3 start-page: 262 year: 2013 ident: ref_78 article-title: Anti-hyperlipidemic activity of aqueous extract of Carica papaya seed in albino rats fed with high fat diet publication-title: Curr. Trends Technol. Sci. – volume: 49 start-page: 3106 year: 2001 ident: ref_25 article-title: Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants publication-title: J. Agric. Food Chem. doi: 10.1021/jf000892m – volume: 40 start-page: 405 year: 1991 ident: ref_69 article-title: Role of oxidative stress in development of complications in diabetes publication-title: Diabetes doi: 10.2337/diab.40.4.405 – volume: 2012 start-page: 436039 year: 2012 ident: ref_2 article-title: Plants’ metabolites as potential antiobesity agents publication-title: Sci. World J. – volume: 1 start-page: 1 year: 2009 ident: ref_50 article-title: Preliminary hypoglycemic and hypolipidemic activities of the aqueous seed extract of Carica papaya Linn in Wistar rats publication-title: Biol. Med. – ident: ref_3 doi: 10.3390/nu10091304 – volume: 15 start-page: 1 year: 2012 ident: ref_30 article-title: Morphological and Biochemical Effects of Dried Leaves of Carica papaya Linn.(Pawpaw) on the Liver in Wistar Rats publication-title: J. Pharm. Biomed. Sci. – volume: 76 start-page: 55 year: 2003 ident: ref_73 article-title: Structure-radical scavenging activity relationships of flavonoids publication-title: Croat. Chem. Acta – volume: 66 start-page: 293 year: 2016 ident: ref_74 article-title: Antioxidant activity of papaya seed extracts against H2O2 induced oxidative stress in HepG2 cells publication-title: LWT Food Sci. Technol. doi: 10.1016/j.lwt.2015.09.008 – volume: 19 start-page: 337 year: 2009 ident: ref_26 article-title: Extratos de sementes de mamão (Carica papaya L.) como fonte de antioxidantes naturais publication-title: Alim. Nutr. Araraquara – volume: 36 start-page: 43 year: 2019 ident: ref_41 article-title: Visceral obesity, skeletal muscle mass and resistin in metabolic syndrome development publication-title: Nutr. Hosp. – volume: 8 start-page: 30606 year: 2017 ident: ref_44 article-title: Metabolic syndrome, endocrine disruptors and prostate cancer associations: Biochemical and pathophysiological evidences publication-title: Oncotarget doi: 10.18632/oncotarget.16725 – volume: 54 start-page: 81 year: 2019 ident: ref_48 article-title: Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet publication-title: Lipids doi: 10.1002/lipd.12128 – volume: 14 start-page: 235 year: 2000 ident: ref_85 article-title: Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat publication-title: Phytother. Res. doi: 10.1002/1099-1573(200006)14:4<235::AID-PTR574>3.0.CO;2-G – volume: 25 start-page: 1982 year: 2011 ident: ref_58 article-title: Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocin-induced diabetic mice publication-title: Nat. Prod. Res. doi: 10.1080/14786419.2010.523703
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Snippet	Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and... L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex... [...]few studies have demonstrated the therapeutic potential in metabolic dysfunctions in experimental models specific to obesity. [...]the present study will...
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SubjectTerms	antioxidants benzyl isothiocyanate beta-carotene beta-cryptoxanthin cardiovascular system Carica Carica papaya cholesterol diabetes mellitus Dietary Supplements flavonoids folic acid free radicals Fruit fruits glucosinolates Humans Hypoglycemia leaves linoleic acid magnesium Metabolic syndrome Metabolic Syndrome - diet therapy minerals nutrients Nutritive Value obesity oils oleic acid palmitic acid pantothenic acid Phytochemicals polyphenols potassium pulp Review saponins seeds stearic acid subtropics tocopherols vitamin A
Title	Nutraceutical Potential of Carica papaya in Metabolic Syndrome
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Volume	11
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